Abstract：
:In previous studies, the flow of albumin solution through hydrated lung interstitial segments was higher than a prior flow of Ringer solution (A. Tajaddinni et al., 1994, J. Appl. Physiol. 76, 578-583). We wondered whether this effect was caused by an increased pore size. We measured the flow of albumin solutions through interstitial segments subjected to a driving pressure of 5 cm H(2)O and various mean interstitial pressures (P(if)). The ratio of albumin concentration (C(alb)) of the output solution to that of the input solution (C(out)/C(in), sieving ratio) was measured using tracer (125)I-albumin. At normal hydration (0 cm H(2)O P(if)), C(out)/C(in) was minimal (0.6) with the flow of Ringer solution, increased to 0.8 with the flow of 5 g/dl albumin solution, and increased to 1 with increased hydration at 15 cm H(2)O P(if). We modeled the interstitium as a membrane subjected to flows of high Peclet numbers. Accordingly, the albumin reflection coefficient [sigma = 1 - (C(out)/C(in))] at 0 cm H(2)O P(if) was 0.4 with the flow of Ringer solution and decreased to 0 at 5 g/dl C(alb) and 15 cm H(2)O P(if). This behavior suggests that the flow of albumin occurred through interstitial pores that increased in size as either C(alb) or hydration increased. We conceive of an interstitium that consists of pores with permeable moveable walls across which osmotic interaction occurs between the pore liquid and the surrounding tissue.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Villarruel S,Ibbott GS,Lai-Fook SJdoi
10.1006/mvre.2001.2363keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
27-40issue
1eissn
0026-2862issn
1095-9319pii
S0026286201923635journal_volume
63pub_type
杂志文章abstract：PURPOSE:Diabetic retinopathy (DR) is characterized by pro-inflammatory, pro-angiogenic and pro-fibrotic environment during the various stages of the disease progression. Basement membrane changes in the retina and formation of fibrovascular membrane are characteristically seen in DR. In the present study the effect of ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.09.001
更新日期：2019-01-01 00:00:00
abstract：:Alterations in the reactivity of arterioles to vasodilator agonists were assessed in the skeletal muscle microcirculation of age-matched, normotensive male Sprague-Dawley rats fed either a high salt (4% NaCl, HS) or a low salt (0.4% NaCl, LS) diet and in reduced renal mass hypertensive rats on a high salt diet (HSRRM)...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2105
更新日期：1998-11-01 00:00:00
abstract：:To compute two parameters of capillary protein transport of reflection coefficient (sigma) and permeability--surface area product (PS), two major methods have been employed. The first, or crosspoint method, uses two sets of lymph flow (Jv) and lymph/plasma protein concentration ratios (R) and solves the irreversible t...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(85)90051-2
更新日期：1985-09-01 00:00:00
abstract：:Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subsequently complicate...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2012.08.003
更新日期：2012-11-01 00:00:00
abstract：:The most universal angiogenic cytokines (VEGF, bFGF, HGF) are all heparin-binding proteins, the function of which is dependent on cell surface heparan sulfate proteoglycans (HSPG). Several proteoglycans have been demonstrated in endothelial cells, but only glypican-1 from the cell surface HSPG subfamily was documented...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2004.05.001
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:The present study was examined whether fluvastatin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, can increase the production of interstitial adenosine via activation of ecto-5'-nucleotidase in the ventricular myocardium, with use of microdialysis techniques in in situ rat hearts. METH...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2016.04.006
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:The conjunctival microcirculation is a readily-accessible vascular bed for quantitative haemodynamic assessment and has been studied previously using a digital charge-coupled device (CCD). Smartphone video imaging of the conjunctiva, and haemodynamic parameter quantification, represents a novel approach. We rep...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2019.103907
更新日期：2019-11-01 00:00:00
abstract：:We present a simple method for isolation and long-term cultivation of porcine and murine cerebral capillary endothelial cells (cEC). Two major points are made. First, that the "characteristic" morphology of the endothelial cells depends mainly on the presence of endothelial cell growth factors in the culture medium an...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90034-4
更新日期：1989-03-01 00:00:00
abstract：:Although vasodilation is conventionally held to be the predominant microvascular response to a wound, there has been no previous attempt to actually quantitate skin blood flow within and in the neighborhood of wounds. In particular, there has been no differentiation between sites with primarily nutritive (NUTR) blood ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1997.2008
更新日期：1997-05-01 00:00:00
abstract：:The key points in the design of microfluidic Lab-On-a-Chips for blood tests are the simplicity of the microfluidic chip geometry, the portability of the monitoring system and the ease on-chip integration of the data analysis procedure. The majority of those, recently designed, have been used for blood separation, howe...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2017.09.003
更新日期：2018-03-01 00:00:00
abstract：:Bile duct obstruction is associated with hepatic accumulation of leukocytes and liver injury. Emerging data suggest that platelets may play an important role in tissue damage and inflammation. Herein, we characterized the platelet response in cholestatic liver injury and evaluated the role of Rho-kinase signaling. For...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.04.003
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:Subcutaneous tissue is a promising site for cell transplantation; advantages include minimally invasive procedures and easy post-transplant monitoring. However, limited vascularity is the major known challenge. To address this challenge, a prevascularized graft bed is prepared in recipients. We aimed to establi...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2020.104070
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:This study aims to investigate the correlation between the expression of miR-210 in peripheral blood and the number of peripheral endothelial progenitor cells (EPCs) in patients with type 2 diabetes mellitus (T2DM). We also determined the effect of miR-210 on EPC proliferation, adhesion, migration, tube forma...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2020.104032
更新日期：2020-09-01 00:00:00
abstract：:Microalbuminuria is a primary manifestation of diabetic nephropathy. Endothelial cell-selective adhesion molecule (ESAM) is a new member of the immunoglobulin superfamily which is selectively expressed by vascular endothelial cells. Although ESAM mediates homophilic interaction between endothelial cells, the role of E...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.01.002
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:Hypertension and hypercholesterolemia elicit inflammatory and thrombogenic responses in the microvasculature. However, little is known about whether and how risk factor combinations alter microvascular function. We examined how the actions of HTN+HCh on the microvasculature differ from the responses elicited ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2016.01.002
更新日期：2016-05-01 00:00:00
abstract：:The relative magnitude of vascular reactivity to inhaled gas stimuli in the major retinal arterioles has not been systematically investigated. The purpose of this study was to compare the magnitude of retinal vascular reactivity in response to inhaled gas provocation at equivalent measurement sites in the superior-, a...
journal_title：Microvascular research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.mvr.2011.11.002
更新日期：2012-03-01 00:00:00
abstract：:Immunological studies of human endothelial cells have been performed almost entirely on endothelial cells (EC) derived from foetal (umbilical vein) or adult (aorta) large vessels. Immunologically these EC have in common the fact that they are negative for major histocompatibility complex (MHC) class II antigens (HLA-D...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1996.0016
更新日期：1996-03-01 00:00:00
abstract：:The first description of endothelial progenitor cells (EPC) in 1997 led rapidly to substantial changes in our understanding of angiogenesis, and within 5 years to the first clinical studies in humans using bone marrow derived EPC to enhance coronary neovascularisation and cardiac function after myocardial ischemia. Ho...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2009.12.004
更新日期：2010-05-01 00:00:00
abstract：:Studies of blood flow in mesentery, cremaster muscle, and small bore glass tubes were performed to obtain a relationship between mean velocity (Vmean) and red cell velocity using the two-slit method under epifluorescence (Vepi) and transillumination (Vtrans) microscopy. The velocities Vepi and Vtrans obtained in vivo ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90020-4
更新日期：1989-07-01 00:00:00
abstract：:Estrogen induces endothelial progenitor cells (EPCs) migration and proliferation, which may serve as a potential target for coronary artery disease, but the mechanisms are unclear. We hypothesized that estrogen receptors (ERs) and phosphatidylinositol 3-kinase (PI3K) signaling pathway, which represent particularly imp...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2007.02.009
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:The relationship between NF-κB Interacting lncRNA (NKILA) and angiogenesis in breast cancer has never been studied. Our study aimed to investigate effect of NKILA on proliferation, migration, apoptosis, as well as angiogenesis in breast cancer. METHODS:NKILA was over-expressed in MDA-MB-231 cells by transfec...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2019.103968
更新日期：2020-05-01 00:00:00
abstract：:This study aims to assess the relationship between spontaneous oscillations in changes in cerebral tissue oxyhemoglobin concentrations (Delta [HbO2]) and arterial blood pressure (ABP) signals in healthy elderly subjects during the resting state using wavelet coherence analysis. Continuous recordings of near-infrared s...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.02.008
更新日期：2014-05-01 00:00:00
abstract：:Vessel size index (R(v), μm) has been proposed as a quantitative magnetic resonance imaging (MRI) derived imaging biomarker in oncology, for the non-invasive assessment of tumour blood vessel architecture and vascular targeted therapies. Appropriate pre-clinical evaluation of R(v) in animal tumour models will improve ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2012.08.001
更新日期：2012-11-01 00:00:00
abstract：:The study deals with the adhesion and proliferation of bovine retina pericytes onto surfaces of poly(hydroxymethylsiloxane) (PHMS) modified either by cold plasma or by low-energy ion beams. The surface treatment was able to convert the original polymer matrix into SiO2-like phases for O2-plasma or ion-mixed SiCxOy(Hz)...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2004.08.003
更新日期：2004-11-01 00:00:00
abstract：:Timely diagnostics of microcirculatory system abnormalities, which are the most severe diabetic complications, is one of the major problems facing modern health care. Functional abnormalities manifest themselves earlier than the structural ones, and therefore their assessment is the issue of primary importance. In thi...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.05.005
更新日期：2018-11-01 00:00:00
abstract：:A microfluidic device was developed for quantifying the migratory and deformability capabilities of a single tumor cell using direct imaging. It was fabricated using photolithography and is made of polydimethysiloxane. Chemotaxis approach was used for directing cell movement, using 10 microm microgaps to restrict the ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2006.06.003
更新日期：2006-11-01 00:00:00
abstract：:Reduced lung capillary expression of angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, and of caveolin-1, an important regulator of endothelial cell signalling, has been demonstrated in various models of pulmonary arterial hypertension (PAH). We addressed the relationship between P...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.04.008
更新日期：2010-09-01 00:00:00
abstract：AIMS:The purpose of the present study was to investigate the possible role of TIPE2 on acute lung injury (ALI) induced by myocardial ischemia/reperfusion (MIR) in diabetic rats. METHODS:Sprague-Dawley (SD) rats were randomly separated into four groups: control+sham (C + sham); control+MIR (C + MIR); diabetes+sham (D +...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2020.104009
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:To examine the possible role of Klotho (Kl) in human microvasculature. METHODS:The expression level of Kl in primary human dermal microvascular endothelial cells (HDMECs) and primary human dermal fibroblasts (HFb) was detected by real-time polymerase chain reaction amplification (qRT-PCR), Western blot analyse...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2016.05.005
更新日期：2016-09-01 00:00:00
abstract：:Angiogenesis is widely accepted to play a central role in tumor growth and spreading. Therefore, anti-angiogenic agents appear as promising tools in cancer therapy, and great efforts have been devoted to their identification in recent years. Despite fast progress in this area, a quantitative and objective system for r...
journal_title：Microvascular research
pub_type：
doi：10.1006/mvre.2001.2389
更新日期：2002-05-01 00:00:00
