Abstract：
:In diabetic patients small fiber neuropathy has been associated with impairment of 0.1 Hz microvascular vasomotion. The aim of this study was (1) to investigate whether vasoconstriction-induced microvascular oscillations in the skin are reduced in diabetic patients with peripheral and/or autonomic neuropathy, and (2) whether this method could be used as a non-invasive surrogate marker to assess diabetic small fiber neuropathy. Four matched groups were studied: diabetic patients without neuropathy (D), with peripheral neuropathy (DPN), with peripheral and autonomic neuropathy (DAN), and non-diabetic controls (Ctrl). All participants were evaluated for peripheral and autonomic neuropathy, microvascular endothelial function, and metabolic syndrome indicators. Laser Doppler flowmetry was used to measure oscillations after iontophoresis of the alpha one selective agonist phenylephrine. approximately 0.1-Hz oscillations recorded at the foot were significantly attenuated in diabetic patients with peripheral and/or autonomic neuropathy (DPN and DAN groups) compared to diabetic patients without neuropathy or non-diabetic controls. In the forearm, microvascular oscillations were significantly reduced only in patients with autonomic neuropathy (DAN). Oscillation measures correlated significantly (P<0.001) with all markers of peripheral neuropathy but not with markers of measurements of microvascular endothelial function, or metabolic syndrome markers. In a logistic regression model, reduced microvascular oscillations at the foot were a strong predictor for the presence of peripheral neuropathy. The measurement of phenylephrine-induced approxiamtely 0.1-Hz microvascular oscillation may represent a useful non-invasive tool with which to study the effects of treatment strategies on the diabetic small fiber neuropathy.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Schmiedel O,Nurmikko TJ,Schroeter ML,Whitaker R,Harvey JNdoi
10.1016/j.mvr.2008.04.004subject
Has Abstractpub_date
2008-08-01 00:00:00pages
124-31issue
2eissn
0026-2862issn
1095-9319pii
S0026-2862(08)00062-9journal_volume
76pub_type
临床试验,杂志文章abstract：:Alterations in the reactivity of arterioles to vasodilator agonists were assessed in the skeletal muscle microcirculation of age-matched, normotensive male Sprague-Dawley rats fed either a high salt (4% NaCl, HS) or a low salt (0.4% NaCl, LS) diet and in reduced renal mass hypertensive rats on a high salt diet (HSRRM)...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2105
更新日期：1998-11-01 00:00:00
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journal_title：Microvascular research
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doi：10.1016/j.mvr.2007.04.012
更新日期：2008-01-01 00:00:00
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journal_title：Microvascular research
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doi：10.1006/mvre.2001.2318
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journal_title：Microvascular research
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journal_title：Microvascular research
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journal_title：Microvascular research
pub_type： 杂志文章
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1993.1004
更新日期：1993-01-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2016.04.001
更新日期：2016-07-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
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更新日期：2018-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.12.002
更新日期：2019-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2006.01.002
更新日期：2006-03-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
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更新日期：2003-09-01 00:00:00
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更新日期：2014-03-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1994.1063
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更新日期：2015-11-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.04.007
更新日期：2015-07-01 00:00:00
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doi：10.1016/j.mvr.2010.03.001
更新日期：2010-07-01 00:00:00
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journal_title：Microvascular research
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doi：10.1016/j.mvr.2009.02.007
更新日期：2009-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1006/mvre.1999.2146
更新日期：1999-05-01 00:00:00
