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Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy.

Abstract：

:We investigated the kinetics of human mesenchymal stem cells (MSCs) after intravascular administration into SCID mouse cremaster vasculature by intravital microscopy. MSCs were injected into abdominal aorta through left femoral artery at two different concentrations (1 x 10(6) or 0.2 x 10(6) cell). Arterial blood velocity decrease by 60 and 18% 1 min after high/low dose MSCs injection respectively. The blood microcirculation was interrupted after 174+/-71 and 485+/-81 s. Intravital microscopy observation and histopathologic analysis of cremaster muscles indicated MSCs were entrapped in capillaries in both groups. 40 and 25% animals died of pulmonary embolism respectively in both high and low MSCs dose groups, which was detected by histopathologic analysis of the lungs. Intraarterial MSCs administration may lead to occlusion in the distal vasculature due to their relatively large cell size. Pulmonary sequestration may cause death in small laboratory animals. MSCs should be used cautiously for intravascular transplantation.

journal_name

Microvasc Res

journal_title

Microvascular research

authors

Furlani D,Ugurlucan M,Ong L,Bieback K,Pittermann E,Westien I,Wang W,Yerebakan C,Li W,Gaebel R,Li RK,Vollmar B,Steinhoff G,Ma N

doi

10.1016/j.mvr.2009.02.001

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

370-6

issue

3

eissn

0026-2862

issn

1095-9319

pii

S0026-2862(09)00069-7

journal_volume

77

pub_type

杂志文章

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