Abstract:
:It has generally been assumed that movement of fluid between the pulmonary microvasculature and surrounding tissues is governed by a "Starling" balance of hydrostatic and protein osmotic forces similar to that which prevails in the extremities. However, both recent and older observations suggest that the lungs are more resistant to edema formation than most other organs. Several structural aspects of the lung may account for protection of the airspaces from edema formation. The pulmonary microvasculature, which comprises >70% of the pulmonary circulatory bed, appears to be less permeable to fluid and electrolytes than the endothelium of the pulmonary arteries and veins and other microvascular exchange areas. This arrangement may help explain why early edema is confined to the perivascular and peribronchial regions and why lymphatics do not reach the alveoli. Unlike the peripheral vasculature, which is compressed by edema formation, the extra-alveolar vessels remain tethered open by airway distention, even when interstitial pressures rise above those in the vessels. This may also facilitate return of proteins to the circulation. Ultrafiltration of plasma may lower local protein concentrations in the interstitium, thereby slowing further edema formation. Transendothelial reabsorption of fluid may also be altered by vesicular transport.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Effros RM,Parker JCdoi
10.1016/j.mvr.2009.03.004subject
Has Abstractpub_date
2009-06-01 00:00:00pages
71-7issue
1eissn
0026-2862issn
1095-9319pii
S0026-2862(09)00088-0journal_volume
78pub_type
杂志文章,评审abstract::A cytochemical study of vascular and cellular development in fetal adipose tissue was conducted utilizing 10 plant lectins (fluorescein isothiocyanate (FITC)-labeled), antibodies against laminin, types II and IV collagen, and a probe for actin. Throughout fetal development (50-110 days) blood vessels were stained by g...
journal_title:Microvascular research
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journal_title:Microvascular research
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journal_title:Microvascular research
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journal_title:Microvascular research
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journal_title:Microvascular research
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pub_type: 杂志文章,评审
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更新日期:2007-09-01 00:00:00
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doi:10.1016/j.mvr.2017.12.001
更新日期:2018-05-01 00:00:00
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