Abstract:
:We studied the absorbing peripheral lymphatic vessel with the light microscope, the transmission electron microscope, the scanning electron microscope, and three-dimensional models of the diaphragm of several rodents and insectivores under normal and experimental conditions (lymphatic stasis and dehydration). To clarify the delicate and complex mechanism that permits drainage of the abdominal cavity contents into the lymphatic circulatory system, we introduced Polystyrene latex spherules, China ink, and Trypan blue into the abdominal cavities. After anatomical comparisons of the superficial and deep networks of absorbing peripheral lymphatic vessels at the tendinous and muscular portions of the diaphragm and after classification of lymphatic vessels into absorbing and conducting functions, we examined the stomata, which, owing to morphologic and topographic findings, we defined as stable structures. Furthermore, we observed that the stomata and submesothelial connective channel are fundamental elements that facilitate the flow of the corpuscular and liquid contents of the peritoneal cavity to the submesothelial absorbing lymphatic vessel wall. Also, we underlined that the genesis of the connective channel depends on the secondary cytoplasm extensions of two distinct adjacent endothelial cells, which, to facilitate the flow of the absorbed abdominal contents, completely coat this channel. Additionally, our observations illustrate that the secondary cytoplasm extensions do not engage in continuous relationships with the basal lamina of the mesothelium and with the margins of the stoma, and, hence, the hypothesis of "lymphatic stomata" as an expression of the anchoring of the borders of the open interendothelial junctions to the orifice margins of the stoma cannot be confirmed. Moreover, we describe the presence and formation of intraendothelial channels in the lymphatic endothelial wall. We affirm that this morphological entity is a dynamic unit, because its numerical density varies according to different physiological and experimental conditions to degrees of hydrostatic and colloidal osmotic pressure and, perhaps, also to the particular characteristics of the substances that the connective channel liberates into the endothelial wall of the lymphatic vessel. In conclusion, we affirm that the absorbing peripheral lymphatic vessels of the diaphragm, by way of intraendothelial channel formations, membrane diffusion, and the vesicular path of the endothelial cells, constitute the fundamental draining elements for the corpuscular and liquid contents of the abdominal cavity.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Azzali Gdoi
10.1006/mvre.1998.2101subject
Has Abstractpub_date
1999-01-01 00:00:00pages
30-43issue
1eissn
0026-2862issn
1095-9319pii
S0026-2862(98)92101-Xjournal_volume
57pub_type
杂志文章abstract::Previous findings have shown that pulmonary fibroblasts are associated with preexisting holes in the endothelial and epithelial basal laminae through which neutrophils appear to enter and leave the interstitium as they migrate from capillaries to alveoli. To determine their role in neutrophil migration, fibroblast org...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1996.0029
更新日期:1996-05-01 00:00:00
abstract::A novel first-pass imaging method for studying blood flow in tumors and normal tissues in mouse dorsal window chamber preparations is reported in this study. A fluorescence-labeled macromolecule is administered i.v. as a bolus dose, and the signal generated by the bolus is detected as the bolus passes through the vasc...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2007.06.009
更新日期:2008-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1999.2224
更新日期:2000-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(83)90044-4
更新日期:1983-01-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(88)90022-2
更新日期:1988-11-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(91)90071-i
更新日期:1991-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2009.02.001
更新日期:2009-05-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(87)90054-9
更新日期:1987-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2016.05.005
更新日期:2016-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.01.007
更新日期:2015-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2012.06.011
更新日期:2012-11-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2008.08.001
更新日期:2009-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2009.02.007
更新日期:2009-06-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2016.04.006
更新日期:2016-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2013.04.001
更新日期:2013-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2020.104009
更新日期:2020-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1993.1022
更新日期:1993-05-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2018.12.005
更新日期:2019-05-01 00:00:00
abstract::The relative magnitude of vascular reactivity to inhaled gas stimuli in the major retinal arterioles has not been systematically investigated. The purpose of this study was to compare the magnitude of retinal vascular reactivity in response to inhaled gas provocation at equivalent measurement sites in the superior-, a...
journal_title:Microvascular research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mvr.2011.11.002
更新日期:2012-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(84)90014-1
更新日期:1984-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2009.05.006
更新日期:2009-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2013.06.004
更新日期:2013-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.12.006
更新日期:2016-05-01 00:00:00
abstract::Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, in part, by equilibrative nucleoside transporter subtype 1 (ENT1; SLC29A1) and by equilibrative nucleobase transporter ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.06.008
更新日期:2014-09-01 00:00:00
abstract::An ex vivo perfused solid tumor preparation provides control over the physiological, biochemical, and pharmacological composition of the arterial input and easy access to the venous output. This is advantageous for studies of transport and metabolism in solid tumors. Here we present a tissue-isolated tumor preparation...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1994.1063
更新日期:1994-11-01 00:00:00
abstract::Ischemia/Reperfusion injury and hemolysis are characterized by erythrocyte lysis and release of free heme into the microcirculation. Following substantial erythrocyte lysis, heme overwhelms circulatory heme-binding protein networks rapidly forming hemin, the oxidized form of iron protoporphyrin IX. Hemin's role in mod...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2007.01.002
更新日期:2007-05-01 00:00:00
abstract::The objective of this study was to provide the first quantitative measurements of the process of vascular growth in the rat peritoneal disseminated tumor model in both arteriolar and venular systems. Male Fischer 344 rats were injected intraperitoneally with 1 x 10(7) cells of colon carcinoma cell line (RCN-9). Three ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1996.0003
更新日期:1996-01-01 00:00:00
abstract::To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the postcapillary venules of rat mesentery in vivo. Exposure to 1 nM VEGF transiently increased P from a mean of 1.4 (+/-0.11 SE...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.03.004
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Understanding the differences in skin blood flow (SBF) on the plantar and dorsal foot in people with diabetes mellitus (DM) may help to assess the influence of diabetes and neuropathy on microvascular dysfunction and risks of diabetic foot ulcers in this population. However, there is no study comparing SBF o...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.11.002
更新日期:2019-03-01 00:00:00
abstract::Liposomally formulated siRNA can be used for RNAi applications in vivo. Intravenous bolus administration of lipoplexed siRNA has been shown to reduce gene expression in the vascular endothelium. Here, we applied immunofluorescence staining for different endothelial markers (PECAM-1, CD34, laminin) on paraffin sections...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2008.02.004
更新日期:2008-05-01 00:00:00