Abstract:
:Endothelial dysfunction is common in patients with chronic kidney disease (CKD) and contributes significantly to the high long-term cardiovascular morbidity and mortality. The short-term cardiovascular effects of recombinant human growth hormone (rhGH) in CKD patients (stages III-V) and healthy controls (n=15 each) were explored in a single-center, non-randomized pilot study. Subjects were investigated before, after a 7 day treatment with rhGH, and after a 7 day wash-out period. Microcirculation was assessed by nailfold capillaroscopy and leg strain gauge plethysmography. Echocardiography was performed and serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3) were determined. Before the start of rhGH therapy, mean post-ischemic maximum flow velocity of erythrocytes (V(RBC)) and leg blood flow (LBF) in CKD patients were significantly reduced to 68% and 75% of that seen in controls, whereas V(RBC) and LBF under resting conditions were comparable. Treatment with rhGH significantly increased V(RBC) and LBF under resting conditions. Whereas maximum post-ischemic V(RBC) was improved by rhGH in patients and controls, maximum post-ischemic LBF increased in controls only. This was paralleled by a non-significant reduction of total vascular resistance, and increased heart rate and cardiac index. In conclusion, CKD patients respond to short-term rhGH treatment with significantly improved capillary blood flow, whereas only minor effects on total peripheral resistance and cardiac output were noted.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Nissel R,Fischer DC,Puhlmann A,Holdt-Lehmann B,Mitzner A,Petzsch M,Körber T,Tiess M,Schmidt R,Haffner Ddoi
10.1016/j.mvr.2009.05.006subject
Has Abstractpub_date
2009-09-01 00:00:00pages
246-52issue
2eissn
0026-2862issn
1095-9319pii
S0026-2862(09)00169-1journal_volume
78pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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