Abstract：
:A study was designed to compare three independent measures of cutaneous blood flow in normal healthy volunteers: xenon-133 washout, helium flux, and laser velocimetry. All measurements were confined to the volar aspect of the forearm. In a large group of subjects we found that helium flux through intact skin changes nonlinearly with the controlled local skin temperature whereas helium flux through stripped skin, which is directly proportional to skin blood flow, changes linearly with cutaneous temperature over the range 33 degrees to 42 degrees. In a second group of six volunteers we compared helium flux through stripped skin to xenon-133 washout (intact skin) at a skin temperature of 33 degrees, and we found an essentially linear relationship between helium flux and xenon measured blood flow. In a third group of subjects we compared helium flux blood flow (stripped skin) to laser doppler velocimetric (LDV) measurements (intact skin) at adjacent skin sites and found a nonlinear increase in the LDV skin blood flow compared to that determined by helium over the same temperature range. A possible explanation for the nonlinear increases of helium flux through intact skin and of LDV output with increasing local skin temperature is that they reflect more than a change in blood flow. They may also reflect physical changes in the stratum corneum, which alters its diffusional resistance to gas flux and its optical characteristics.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Neufeld GR,Galante SR,Whang JM,DeVries D,Baumgardner JE,Graves DJ,Quinn JAdoi
10.1016/0026-2862(88)90058-1subject
Has Abstractpub_date
1988-03-01 00:00:00pages
143-52issue
2eissn
0026-2862issn
1095-9319pii
0026-2862(88)90058-1journal_volume
35pub_type
杂志文章abstract：:Studies of microvascular geometry made from microscope observations of tissues in vivo or after perfusion with a silastic elastomer or india ink are restricted to a two-dimensional field of view. Microvascular corrosion casts, however, if of sufficient rigidity and structural integrity, can yield three-dimensional inf...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(83)90044-4
更新日期：1983-01-01 00:00:00
abstract：:The contribution of the pleural mesothelium to pleural liquid and protein transport is still vigorously debated. Recent in vitro studies of stripped pleural membrane and free-standing pericardium have demonstrated active ion solute coupled transport of liquid and transcytosis of protein. However, the relative contribu...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2005.10.003
更新日期：2005-11-01 00:00:00
abstract：:Nonspecific vasodilatation during iontophoresis is an important confounding factor in experimental pharmacology. In this investigation, we studied the involvement of sensory nerves and histamine-related reactions in causing nonspecific vasodilatation in a model of anodal and cathodal iontophoresis of sodium chloride. ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2003.12.002
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:The conjunctival microcirculation is a readily-accessible vascular bed for quantitative haemodynamic assessment and has been studied previously using a digital charge-coupled device (CCD). Smartphone video imaging of the conjunctiva, and haemodynamic parameter quantification, represents a novel approach. We rep...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2019.103907
更新日期：2019-11-01 00:00:00
abstract：:The angiopoietin/Tie2 system is a predominant regulator of vascular development. This vascular development appears to be controlled and completed by the coordinated actions of two vascular cells, endothelial cells and their surrounding supporting cells, smooth muscle cells, or pericytes. The role of the angiopoietin/T...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/s0026-2862(02)00035-3
更新日期：2003-03-01 00:00:00
abstract：:Synthetic big endothelin-1 (ET-1), a 39-residue precursor of ET-1, has been reported to elicit potent contractile action on helical strip specimens obtained from the porcine coronary artery, but its molar potency was found to be 140-fold lower than that of ET-1 [Saito, Y., Nakao, K., Mukoyama, M., Imura, H., 1990. Inc...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2006.04.007
更新日期：2006-11-01 00:00:00
abstract：:Carrier-immobilized carbohydrates are valuable tools for assessing the glycoligand-binding capacity of cell surfaces. A panel of 10 types of fluorescent neoglycoproteins has been synthesized to determine the extent of their specific binding to endothelial cells in vitro that have been obtained from porcine brain, ovar...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1995.1053
更新日期：1995-09-01 00:00:00
abstract：:The Raynaud's phenomenon often accompanies systemic rheumatic diseases and is also known as a vascular side effect of chemotherapy. Therapy of the Raynaud's phenomenon with nitrates or calcium-channel-blockers is rarely beneficial. In contrast, the PDE-V-inhibitor sildenafil seems to be effective in these patients. Fo...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2005.03.001
更新日期：2005-05-01 00:00:00
abstract：:We previously reported that the cutaneous vasodilator response to local warming in males required noradrenaline (NA) and neuropeptide-Y (NPY). Animal work has shown no role for NPY in female vascular control. We investigated the contribution of NA and NPY in human female cutaneous vascular control. Nine female and nin...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2017.04.003
更新日期：2017-09-01 00:00:00
abstract：:A large loss of blood during hemorrhage can result in profound shock, a state of hypotension associated with hemodynamic abnormalities. One of the hypotheses to account for this collapse of homeostasis is that the production of nitric oxide (NO), a gas molecule that dilates blood vessels, is significantly impaired dur...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.02.009
更新日期：2009-06-01 00:00:00
abstract：:The fluorescence ratio imaging technique is currently applied in vitro and in vivo to measure intracellular as well as extracellular pH. To date, however, no effort has been made to assess the technique's ability to detect spatial pH gradients in vitro or in vivo, where pH gradients are known to exist, in a controlled...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1993.1048
更新日期：1993-09-01 00:00:00
abstract：OBJECTIVE:Leukocytes play a key role in the early response to tissue injury/infection resulting from physical, chemical or biological stimuli. This process involves the initiation of the leukocyte adhesion cascade mediated by a series of interactions between receptors and ligands on the endothelium and the leukocytes. ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.03.007
更新日期：2013-09-01 00:00:00
abstract：:A theoretical model, appropriate for data interpretation, is presented for the transcapillary fluid exchange and associated intraluminal hydrodynamic and solute transport occurring in the microocclusion of single capillaries. This analysis describes the spatial and temporal behavior of the intraluminal flow. A compari...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(83)90012-2
更新日期：1983-03-01 00:00:00
abstract：:We have applied theories of mass transfer, in laminar and turbulent flow, to red cells in the stopped-flow apparatus in order to estimate the effect of extracellular diffusion boundary layers on the initial rate of O2 uptake. We compared the theoretical predictions with the results of our previous stopped-flow experim...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(83)90058-4
更新日期：1983-07-01 00:00:00
abstract：:Blood flow studies in the brain, heart, and other organs suggest that there could be interaction between nitric oxide (NO) and adenosine. This possibility was investigated in the optic nerve head (ONH) during photic stimulation of the dark-adapted cat eye. Functional activation of ONH blood flow was measured by laser ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2002.2432
更新日期：2002-09-01 00:00:00
abstract：:Living mesenteric capillaries with either an intact or disrupted glycocalyx were challenged with ramp change in shear stress (Deltatau). Animals (Rana pipiens) were divided randomly into two experimental groups, and two true capillaries (TC) per animal were investigated. The modified Landis technique was combined with...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.12.001
更新日期：2010-03-01 00:00:00
abstract：:Leptin, a circulating hormone secreted mainly from adipose tissues, is involved in the control of body weight. Recently, leptin was found to be an angiogenic factor, and its vitreous levels are associated with angiogenic eye diseases such as proliferative diabetic retinopathy. However, the molecular mechanism for lept...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/s0026-2862(03)00005-0
更新日期：2003-05-01 00:00:00
abstract：:We determined whether the solvent drag reflection coefficient (sigma f) for total proteins of a canine perfused left lower lung lobe (LLL) preparation decreases at elevated venous pressures (Pv). We found that sigma f (estimated using the hematocrit-protein technique) remained constant at all Pv's (30-95 mm Hg) evalua...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(92)90006-b
更新日期：1992-01-01 00:00:00
abstract：:Neutrophil-derived hydrogen peroxide (H2O2) is believed to play an important role in inflammatory lung injury. We investigated the influence of pharmacological agents that increase intracellular c-AMP levels on endothelial and epithelial leakage in response to intravascular H2O2 challenge in buffer-perfused rabbit lun...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1995.1033
更新日期：1995-07-01 00:00:00
abstract：:The aim of this study was to evaluate whether streptokinase (SK) may produce beneficial effects at the level of microvascular circulation in addition to coronary recanalization. Twenty mongrel dogs weighing 28.4 +/- 4.6 kg were randomized to receive SK (16,000-72,000 U/kg) or 20 ml saline (control) in an open-chest an...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2000.2236
更新日期：2000-07-01 00:00:00
abstract：:To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the postcapillary venules of rat mesentery in vivo. Exposure to 1 nM VEGF transiently increased P from a mean of 1.4 (+/-0.11 SE...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2004.03.004
更新日期：2004-07-01 00:00:00
abstract：:In diabetic patients small fiber neuropathy has been associated with impairment of 0.1 Hz microvascular vasomotion. The aim of this study was (1) to investigate whether vasoconstriction-induced microvascular oscillations in the skin are reduced in diabetic patients with peripheral and/or autonomic neuropathy, and (2) ...
journal_title：Microvascular research
pub_type： 临床试验,杂志文章
doi：10.1016/j.mvr.2008.04.004
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Endothelial cells are suggested regulators of tumor response to radiation. Anti-vascular targeting agents can enhance tumor response by targeting endothelial cells. Here, we have conducted experiments in vitro to discern the effects of radiation combined with the anti-angiogenic Sunitinib on endothelial (HUV...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.10.008
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS:Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospe...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.07.007
更新日期：2015-11-01 00:00:00
abstract：:Lipopolysaccharide released during bacterial sepsis causes acute lung injury and ARDS. Pulmonary microvascular injury is a feature of ARDS, and vascular remodeling develops, leading to pulmonary hypertension. Pericytes in the lung circulation proliferate and contribute to the remodeling seen in experimental sepsis. It...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2085
更新日期：1998-09-01 00:00:00
abstract：:Rho-associated kinases are involved in regulation of actin-myosin contractility and the organization of the actin cytoskeleton in both endothelial and smooth muscle cells. By influencing the contraction of the intraendothelial filaments, Rho kinases may affect the size of the interendothelial gaps and thereby influenc...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/s0026-2862(03)00041-4
更新日期：2003-09-01 00:00:00
abstract：:A well developed capillary bed is essential for proper function of skeletal muscles. We present for the first time a triple immunofluorescent method suitable for staining capillaries and muscle fibre outlines in thick sections of human skeletal muscle, applying antibodies against collagen IV (in red) and F8 (in green)...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.11.012
更新日期：2011-03-01 00:00:00
abstract：:Oxidative stress, which is defined as an imbalance between proxidant and antioxidant systems, is the essential mechanism involving in the ischemic process. During the early stage of brain ischemia, reactive oxygen species (ROS) are increased. Increased ROS are thought of a consequence of brain ischemia and exacerbatin...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2018.12.005
更新日期：2019-05-01 00:00:00
abstract：:A microvascular network model described in the preceding paper (B. Dawant, M. Levin, and A. S. Popel, 1986, Microvasc. Res. 31, 203-222) featuring random distribution of vessel diameters and lengths, is extended to calculate the distributions of red blood cell flux and discharge hematocrit throughout the network. A re...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(86)90036-1
更新日期：1986-03-01 00:00:00
abstract：:The effects of systemic injections of vasoactive substances were studied in the micro-circulation of the hamster skin fold window preparation, which can be observed without anesthesia, exposure, and acute surgical procedures. The effects were characterized by the continuous measurement of the diameter of the arterial ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(84)90014-1
更新日期：1984-09-01 00:00:00
