Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation.

abstract：:The effect of isoprenaline infusion (1 gamma/min) on blood flow in the extremities was studied in 15 Raynaud's disease (RD) patients and 9 healthy controls. A highly significant (P less than 0.0005) decrease in blood flow was seen in the RD subjects. It is suggested that an increased presynaptic beta receptor response...

journal_title：Microvascular research

authors： Giovanni B,Giuseppina CM,Susanna F,Roberto M

更新日期：1984-01-01 00:00:00

abstract：:In a novel assay of angiogenesis in the quail chorioallantoic membrane (CAM), we measured vascular pattern and angiogenic rate after homogeneous exposure of the entire vascular tree to recognized modulators of vessel growth. In comparison to phosphate-buffered saline (PBS)-treated controls, the vascular stimulator, ba...

journal_title：Microvascular research

authors： Parsons-Wingerter P,Lwai B,Yang MC,Elliott KE,Milaninia A,Redlitz A,Clark JI,Sage EH

更新日期：1998-05-01 00:00:00

abstract：:There is evidence that vascular beds distal to the ophthalmic artery (OA) show vasoconstriction in response to a step decrease in systemic blood pressure (BP). The mediators of this response are mostly unidentified. The aim of the current study was to test the hypothesis that α2-adrenoreceptors may contribute to the r...

journal_title：Microvascular research

authors： Kaya S,Kolodjaschna J,Berisha F,Polska E,Pemp B,Garhöfer G,Schmetterer L

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to determine if there are intrinsic differences in resting tone, vascular reactivity, myogenic responses, and neurogenic vasoconstriction between the large and small feeder arteries and first order arterioles (1A) of the rat cremaster muscle. The pudic-epigastric artery (PEA), external sp...

journal_title：Microvascular research

authors： Sylvester FA,Frisbee JC,Lombard JH

更新日期：2000-09-01 00:00:00

abstract：:We have developed an intensity analysis technique for fluorescence microscopy that allows us to measure, in real time, the diameter and the membrane potential or intracellular calcium ([Ca(2+)]i) of in vivo arteriolar endothelium or smooth muscle. Cheek pouch arterioles of anesthetized hamsters were luminally or ablum...

journal_title：Microvascular research

authors： Chen Y,Rivers RJ

更新日期：2001-07-01 00:00:00

abstract：:The fluorescence ratio imaging technique is currently applied in vitro and in vivo to measure intracellular as well as extracellular pH. To date, however, no effort has been made to assess the technique's ability to detect spatial pH gradients in vitro or in vivo, where pH gradients are known to exist, in a controlled...

journal_title：Microvascular research

authors： Martin GR,Jain RK

更新日期：1993-09-01 00:00:00

abstract：:Particle adhesion in vivo is highly dependent on the microvascular environment comprising of unique anatomical, geometrical, physiological fluid flow conditions and cell-particle and cell-cell interactions. Hence, proper design of vascular-targeted drug carriers that efficiently deliver therapeutics to the targeted ce...

journal_title：Microvascular research

authors： Lamberti G,Soroush F,Smith A,Kiani MF,Prabhakarpandian B,Pant K

更新日期：2015-05-01 00:00:00

abstract：:Lymphangiogenesis is thought to be essential for cancer progression, making it an important target in cancer therapy. Lymphangiogenic factors (VEGF-C and VEGF-D) are upregulated in various tumors/cancers, and play an important role in lymphangiogenesis and lymph node metastasis. Similarly, semaphorin 4D (Sema4D) is a ...

journal_title：Microvascular research

authors： Liu H,Yang Y,Xiao J,Yang S,Liu Y,Kang W,Li X,Zhang F

更新日期：2014-05-01 00:00:00

abstract：:Arterioles in various vascular beds have been often observed to have nonuniform diameters along the vessel axis. The effect of nonuniformity of arteriolar diameter on vascular resistance was investigated using a theoretical model of blood flow in arterioles. Viscous flow of a Newtonian fluid in tubes with periodically...

journal_title：Microvascular research

authors： Sugihara-Seki M,Minamiyama M,Hanai S

更新日期：1989-09-01 00:00:00

abstract：:Local skin heating to 42°C causes rapid increases in cutaneous perfusion (initial peak), followed by a brief nadir and subsequent sustained elevation (plateau). Several studies have demonstrated that nitric oxide synthase (NOS) largely contributes to the plateau response during local heating. In this study, we tested ...

journal_title：Microvascular research

authors： Fujii N,Halili L,Nishiyasu T,Kenny GP

更新日期：2018-05-01 00:00:00

abstract：:Interactions between migratory endothelial cells (ECs) and surrounding extracellular matrix (ECM) are of central importance to vascular growth. Here, we present a new model of EC migration and morphogenesis within three-dimensional ECM termed "radial invasion of matrix by aggregated cells" (RIMAC). In the RIMAC model,...

journal_title：Microvascular research

authors： Vernon RB,Sage EH

更新日期：1999-03-01 00:00:00

abstract：:The microcirculation in normal and arthritic juxtaarticular bone was studied in 16 young dogs with carragheenan-induced arthritis of one knee. The regional blood flow was determined by the tissue uptake of intracardially injected 15-microns 141Ce-labeled microspheres, and the microvascular plasma volume was determined...

journal_title：Microvascular research

authors： Hansen ES,Søballe K,Kjølseth D,Henriksen TB,He SZ

更新日期：1990-09-01 00:00:00

abstract：:We tested the hypothesis that the endothelial nitric oxide (NO)-soluble guanylyl cyclase system is involved in atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) mediated regulation of coronary and peripheral vascular resistance. Rat hearts were perfused via the aorta at constant flow and the effect...

journal_title：Microvascular research

authors： Brunner F,Wölkart G

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Vascular hyporeactivity in severe hemorrhagic shock could induce refractory hypotension and is an important cause of death. The global acute inflammatory response induced in shock triggers the over-expression of reactive oxygen species, NO, ET1 and TNF-α, which play essential roles in the pathology of vascul...

journal_title：Microvascular research

authors： Chen D,Song MQ,Liu YJ,Xue YK,Cheng P,Zheng H,Chen LB

更新日期：2016-05-01 00:00:00

abstract：:Cardiovascular diseases, among all diseases, are taking the most victims worldwide. Coronary artery occlusion, takes responsibility of about 30% of the yearly global deaths in the world (Heart Disease and Stroke Statistics 2017 At-a-Glance, 2017), raising the need for viable substitutes for cardiovascular tissues. Dep...

journal_title：Microvascular research

authors： Aslani S,Kabiri M,HosseinZadeh S,Hanaee-Ahvaz H,Taherzadeh ES,Soleimani M

更新日期：2020-09-01 00:00:00

abstract：:Endometriosis, the presence of endometrium-like tissue outside of the uterine cavity, is a common disease among women of reproductive age. Typical symptoms include abdominal pain and painful menstruation. In addition, endometriosis is associated with reduced fertility. Current treatment modalities, the surgical remova...

journal_title：Microvascular research

authors： Becker CM,D'Amato RJ

更新日期：2007-09-01 00:00:00

abstract：:An increased recognition of the role of endothelial cells in disease and the development of methods for endothelial cell culture has led to an upsurge in in vitro studies of endothelial cell function. However, the cells most often used for these studies do not reflect the in vivo heterogeneity of endothelial cells. To...

journal_title：Microvascular research

authors： Craig LE,Spelman JP,Strandberg JD,Zink MC

更新日期：1998-01-01 00:00:00

abstract：:A study was designed to compare three independent measures of cutaneous blood flow in normal healthy volunteers: xenon-133 washout, helium flux, and laser velocimetry. All measurements were confined to the volar aspect of the forearm. In a large group of subjects we found that helium flux through intact skin changes n...

journal_title：Microvascular research

authors： Neufeld GR,Galante SR,Whang JM,DeVries D,Baumgardner JE,Graves DJ,Quinn JA

更新日期：1988-03-01 00:00:00

abstract：:Despite intensive study in the area of angiogenesis, relatively little is known about normal angiogenesis in adult animals. Preliminary studies using the Griffonia simplicifolia I (GSI) lectin as a microvascular marker indicated that capillary sprouting occurs in the clear "windows" of normal intact adult rat mesenter...

journal_title：Microvascular research

authors： Hansen-Smith FM,Joswiak GR,Baustert JL

更新日期：1994-05-01 00:00:00

abstract：:We tested the hypothesis that p42/44MAPK and p38MAPK (mitogen-activated protein kinases; MAPK) signaling pathways regulate endothelial cell permeability to macromolecules. Passage 2-4 human umbilical vein endothelial cells (HUVEC) were grown to confluence on fibronectin-coated Snapwell membranes. The flux of fluoresce...

journal_title：Microvascular research

authors： Varma S,Breslin JW,Lal BK,Pappas PJ,Hobson RW 2nd,Durán WN

更新日期：2002-03-01 00:00:00

abstract：:Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subsequently complicate...

journal_title：Microvascular research

authors： Woolnough C,Wang Y,Kan CY,Morris JM,Tasevski V,Ashton AW

更新日期：2012-11-01 00:00:00

abstract：:Ischemia/Reperfusion injury and hemolysis are characterized by erythrocyte lysis and release of free heme into the microcirculation. Following substantial erythrocyte lysis, heme overwhelms circulatory heme-binding protein networks rapidly forming hemin, the oxidized form of iron protoporphyrin IX. Hemin's role in mod...

journal_title：Microvascular research

authors： Natarajan R,Fisher BJ,Fowler AA 3rd

更新日期：2007-05-01 00:00:00

abstract：:The distribution of anionic sites in the basal laminae of the blood capillaries of the murine pancreas was studied in specimens fixed in ruthenium red (RR)-glutaraldehyde mixtures. The sites appeared as discrete, small (6 to 18 nm) particles distributed throughout the three laminae but concentrated primarily in the la...

journal_title：Microvascular research

authors： Simionescu M,Simionescu N,Palade GE

更新日期：1984-11-01 00:00:00

abstract：:The size of hyaluronan in lymph and gastrocnemius muscle was measured to test the hypothesis that reperfusion of ischemic skeletal muscle leads to hyaluronan depolymerization. Prenodal lymph was collected from the gastrocnemius muscle in anesthetized rabbits. Hyaluronan size was measured using a combination of agarose...

journal_title：Microvascular research

authors： Armstrong SE,Bell DR

更新日期：2002-09-01 00:00:00

abstract：:Neutrophil-derived hydrogen peroxide (H2O2) is believed to play an important role in inflammatory lung injury. We investigated the influence of pharmacological agents that increase intracellular c-AMP levels on endothelial and epithelial leakage in response to intravascular H2O2 challenge in buffer-perfused rabbit lun...

journal_title：Microvascular research

authors： Seeger W,Hansen T,Rössig R,Schmehl T,Schütte H,Krämer HJ,Walmrath D,Weissmann N,Grimminger F,Suttorp N

更新日期：1995-07-01 00:00:00

abstract：:Failure of the glomerular barrier causing proteinuria has been modeled chiefly by Chang, Deen, and Brenner. They have refined models from an isoporous filter to a mostly isoporous membrane, which during proteinuric disease opens up nondiscriminating shunts. This report extends these concepts by measuring a larger dist...

journal_title：Microvascular research

authors： Katz MA,Schaeffer RC Jr,Gratrix M,Mucha D,Cárbajal J

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:The present study was examined whether fluvastatin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, can increase the production of interstitial adenosine via activation of ecto-5'-nucleotidase in the ventricular myocardium, with use of microdialysis techniques in in situ rat hearts. METH...

journal_title：Microvascular research

authors： Obata T,Nakashima M

更新日期：2016-09-01 00:00:00

abstract：:Hemorrhage is responsible for a large percentage of trauma-related deaths but the mechanisms underlying tissue ischemia are complex and not well understood. Despite the evidence linking glycocalyx degradation and hemorrhagic shock, there is no direct data obtained in vivo showing glycocalyx thickness reduction in skel...

journal_title：Microvascular research

authors： Torres Filho I,Torres LN,Sondeen JL,Polykratis IA,Dubick MA

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:High aerobic fitness may prevent age-related decrements in cutaneous vasodilation while type 2 diabetes may exacerbate this decline. The mechanisms underlying these responses remain unclear, but may be due to an excess of reactive oxygen species. We hypothesized that superoxide scavenging or NADPH oxidase inh...

journal_title：Microvascular research

authors： McGarr GW,Fujii N,McNeely BD,Hatam K,Nishiyasu T,Sigal RJ,Boulay P,Kenny GP

更新日期：2019-09-01 00:00:00

abstract：:The object of the present study was to employ specific pharmacological agents and the chemical sympatholytic drug 6-hydroxydopamine (6-OHDA) to characterize the neural and adrenergic control of vascular smooth muscle tone in arterioles of the hamster cheek pouch. Arteriolar diameters were measured in the superfused ch...

journal_title：Microvascular research

authors： Lombard JH,Chenoweth JL,Stekiel WJ

更新日期：1985-01-01 00:00:00