Abstract:
:Cardiovascular diseases, among all diseases, are taking the most victims worldwide. Coronary artery occlusion, takes responsibility of about 30% of the yearly global deaths in the world (Heart Disease and Stroke Statistics 2017 At-a-Glance, 2017), raising the need for viable substitutes for cardiovascular tissues. Depending on a number of factors, blocked coronary arteries are now being replaced by autografts or stents. Since the autografts, as the gold standard coronary artery replacements, are not available in adequate quality and quantity, the demand for small diameter vascular substitute comparable to native vessels is rapidly growing. Synthetic grafts have been successfully approved for developing vascular replacements but regarding the special conditions in small-caliber vessels, their use is limited to large-diameter vascular tissue engineering. The major problems associated with the vascular tissue engineered grafts are thrombosis and intimal hyperplasia. Heparin, a negatively charged natural polysaccharide has been used in fabricating vascular grafts since it prevents protein fouling on the surfaces and most importantly, impeding thrombosis. Herein, we focused on heparin, as a multifunctional bioactive molecule that not only serves as an anticoagulant with frequent clinical use but also acts as an anti-inflammatory and angiogenic regulatory substance. We summarized heparin incorporation into stents and grafts and their applicability to restrain restenosis. Also, the applications of heparinzation of biomaterials and heparin mimetic polymers and different approaches invoked to improve heparin bioactivity have been reviewed. We summarized the methods of adding heparin to matrices as they were explained in the literature. We reviewed how heparin influences the biocompatibility of the scaffolds and discussed new advances about using heparin in small-diameter vascular tissue engineering.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Aslani S,Kabiri M,HosseinZadeh S,Hanaee-Ahvaz H,Taherzadeh ES,Soleimani Mdoi
10.1016/j.mvr.2020.104027subject
Has Abstractpub_date
2020-09-01 00:00:00pages
104027eissn
0026-2862issn
1095-9319pii
S0026-2862(20)30087-Xjournal_volume
131pub_type
杂志文章,评审abstract::Oxidative stress, which is defined as an imbalance between proxidant and antioxidant systems, is the essential mechanism involving in the ischemic process. During the early stage of brain ischemia, reactive oxygen species (ROS) are increased. Increased ROS are thought of a consequence of brain ischemia and exacerbatin...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2018.12.005
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:Diabetic retinopathy (DR) is characterized by pro-inflammatory, pro-angiogenic and pro-fibrotic environment during the various stages of the disease progression. Basement membrane changes in the retina and formation of fibrovascular membrane are characteristically seen in DR. In the present study the effect of ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.09.001
更新日期:2019-01-01 00:00:00
abstract::The purpose of this study was to elucidate the mechanism by which bradykinin (BK) enhances prostacyclin (PGI(2)) production in human umbilical vein endothelial cells (HUVEC). BK-induced enhancement of PGI(2) synthesis was observed in a dose- and time-dependent manner, and it also increased [Ca(2+)](i) followed by enha...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1999.2163
更新日期:1999-09-01 00:00:00
abstract::Vascular dysfunction is an important pathophysiologic manifestation of sickle cell disease (SCD), a condition that increases risk of pulmonary hypertension and stroke. We hypothesized that infrared (IR) imaging would detect changes in cutaneous bloodflow reflective of vascular function. We performed IR imaging and con...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2012.06.011
更新日期:2012-11-01 00:00:00
abstract::An intravital microscopic method for quantitative measurement of interstitial concentrations of fluorescent tracers has been applied to the investigation of microvascular permeability in the hamster cheek pouch. Some nanoliters of FITC-dextran mean mol wt (Mw) 20,000, 3000, or sodium fluorescein (Mw 376) were injected...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(86)90009-9
更新日期:1986-01-01 00:00:00
abstract::7-Ketocholesterol (7kCh) is a major oxysterol found associated with vascular diseases. Human microvascular endothelial cells (HMVECs) were cultured with different concentrations of 7kCh with and without inhibitors. Cell viabilities and caspase activities were assessed. 7kCh caused loss of cell viability in a dose-depe...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2007.10.003
更新日期:2008-04-01 00:00:00
abstract::The contractile responses of cultured rat and calf endothelial cells (EC), vascular smooth muscle cells (VSMC), and fibroblasts (FB) to vasoactive mediators (thrombin, serotonin, bradykinin, and histamine), forskolin, and cytochalasin B were compared. Cells were grown on a pliable silicone membrane, and contraction wa...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(92)90015-h
更新日期:1992-03-01 00:00:00
abstract::Metabolic syndrome (MetS) is a combination of clinical disorders that together increase the risk for cardiovascular disease and diabetes. SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats with MetS show impaired nitric oxide-mediated relaxation in coronary and mesenteric arteries, and angiotensin II receptor type 1 blockers pr...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2013.04.001
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Sepsis is a fatal systemic inflammatory response syndrome caused by severe infection. The aim of this study was to measure hepatic microcirculation during the sepsis with laser speckle contrast imaging (LSCI), as well as investigating the underlying mechanisms. METHODS:Sepsis was induced by cecal ligation a...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.10.006
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS:Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospe...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.07.007
更新日期:2015-11-01 00:00:00
abstract::The effect of hemodilution on oxygen delivery to the tissue was investigated analytically by taking into consideration the oxygen loss that occurs along the arterial microvasculature due to diffusion into the tissue and shunting to parallel running venules. The theoretical findings were related to experimental data on...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(87)90062-8
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVES:The advanced glycation end products (AGEs)-receptor for AGE (RAGE) axis activity are implicated in diabetic vascular complications. We measured serum AGE, sRAGE and pentosidine levels in Tunisian patients with diabetic retinopathy (DR) and examined whether these biomarkers are related to the severity of DR. ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2012.07.006
更新日期:2012-11-01 00:00:00
abstract::Microalbuminuria is a primary manifestation of diabetic nephropathy. Endothelial cell-selective adhesion molecule (ESAM) is a new member of the immunoglobulin superfamily which is selectively expressed by vascular endothelial cells. Although ESAM mediates homophilic interaction between endothelial cells, the role of E...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2009.01.002
更新日期:2009-05-01 00:00:00
abstract::Studies of blood flow in mesentery, cremaster muscle, and small bore glass tubes were performed to obtain a relationship between mean velocity (Vmean) and red cell velocity using the two-slit method under epifluorescence (Vepi) and transillumination (Vtrans) microscopy. The velocities Vepi and Vtrans obtained in vivo ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(89)90020-4
更新日期:1989-07-01 00:00:00
abstract::We tested the hypothesis that p42/44MAPK and p38MAPK (mitogen-activated protein kinases; MAPK) signaling pathways regulate endothelial cell permeability to macromolecules. Passage 2-4 human umbilical vein endothelial cells (HUVEC) were grown to confluence on fibronectin-coated Snapwell membranes. The flux of fluoresce...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.2001.2381
更新日期:2002-03-01 00:00:00
abstract::Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, in part, by equilibrative nucleoside transporter subtype 1 (ENT1; SLC29A1) and by equilibrative nucleobase transporter ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.06.008
更新日期:2014-09-01 00:00:00
abstract::The main objective of this study was to identify molecular mechanisms through which angiopoietin-1 (Ang-1), a ligand for Tie-2 receptors, influences endothelial cell apoptosis. Human umbilical vein endothelial cells were cultured in a medium enriched with 2% fetal bovine serum (FBS) and growth supplements. Apoptosis w...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.2002.2421
更新日期:2002-07-01 00:00:00
abstract::Laser Doppler flowmetry (LDF) of forearm skin blood flow, combined with iontophoretically-administered acetylcholine and sodium nitroprusside and wavelet spectral analysis, was used for noninvasive evaluation of endothelial function in 17 patients newly diagnosed with New York Heart Association class II-III congestive...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2008.07.006
更新日期:2008-11-01 00:00:00
abstract::We explored the role of 20-hydroxy-5Z, 8Z, 11Z, 14Z-eicosatetraenoic acid (20-HETE) in oxygen-induced vasoconstriction in a normal renin form of hypertension [the 1 kidney-1 clip Goldblatt hypertensive rat (1K1C)] and a high renin form of hypertension [the 2 kidney-1 clip Goldblatt hypertensive rat (2K1C)]. A silver c...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2009.09.002
更新日期:2009-12-01 00:00:00
abstract::To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the postcapillary venules of rat mesentery in vivo. Exposure to 1 nM VEGF transiently increased P from a mean of 1.4 (+/-0.11 SE...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.03.004
更新日期:2004-07-01 00:00:00
abstract::Since the internal carotid artery supplies blood to both the eye and the brain, ocular microvascular hemodynamics can be altered due to ischemic stroke. The purpose of the current study was to establish the feasibility of conjunctival microcirculation imaging for detection of inter-ocular differences in microvascular ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.04.007
更新日期:2015-07-01 00:00:00
abstract::The extravascular uptake for labeled albumin and IgG and the extravascular masses for endogenous albumin and IgG were measured in skin and skeletal muscle from anesthetized rabbits following 24 hr of intermittent plasmapheresis. An amount of protein equivalent to the total intravascular protein mass was removed. There...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(92)90089-8
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:The burden of type 1 diabetes (T1D) is growing worldwide, stressing the requirement to limit the threat of its long-term complications. In this regard, the development of methods for the early diagnosis and non-invasive monitoring of vascular abnormalities is widely recognized as one of the greatest prioriti...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.04.002
更新日期:2019-07-01 00:00:00
abstract::Fluid homeostasis is required for life. Processes involved in fluid balance are strongly related to exchanges at the microvascular level. Computational models have been presented in the literature to analyze the microvascular-interstitial interactions. As far as we know, none of those models consider a physiological d...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.11.003
更新日期:2019-03-01 00:00:00
abstract::Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis in the mammalian eye, suggesting that loss of PEDF is implicated in the pathogenesis of proliferative diabetic retinopathy. However, a role for PEDF in early diabetic retinopathy remains to be elucidated. Since oxidative stress is thought t...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.11.001
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:In this study we aimed to evaluate effects of liver resection on hepatic microcirculation. In addition we wanted to study if histological liver damage could be detected intra-operatively. PATIENTS AND METHODS:40 patients undergoing hepatic resection were included and grouped according to if they were operat...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.05.002
更新日期:2014-07-01 00:00:00
abstract::Alveolar epithelial and endothelial cell death caused by mechanical over-distension is likely to contribute to ventilator-induced lung injury (VILI). Consequently, the search for cytoprotective interventions is of interest. We investigated the effect of the mTOR inhibitor rapamycin on human pulmonary microvascular end...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2009.01.012
更新日期:2009-05-01 00:00:00
abstract::Homeostasis around vascular endothelium is a function of the equilibrium between the bioavailability of nitric oxide (NO) and oxidizing reactive oxygen species (ROS). Within the vascular endothelium, NO enhances vasodilatation, reduces platelet aggression and adhesion (anti-thrombotic), prevents smooth muscle prolifer...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2018.03.012
更新日期:2018-09-01 00:00:00
abstract::The fluidity (the inverse of viscosity) of red blood cell (RBC) suspensions in vivo was estimated by means of microcirculatory measurements such as RBC flow velocity, micropressure in arterioles and venules, and vessel geometry, and by means of simultaneous macrocirculatory measurements such as volume flow and perfusi...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(88)90051-9
更新日期:1988-01-01 00:00:00
abstract::Controversy exists concerning whether activation of N-methyl-D-aspartate (NMDA) receptors exerts direct dilator effects on cerebral arteries. The purpose of this study was to examine the responses of isolated piglet arteries to NMDA to determine whether isolated arteries, apart from surrounding neuronal tissue, are ca...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2005.04.007
更新日期:2005-07-01 00:00:00