Abstract:
:The effect of hemodilution on oxygen delivery to the tissue was investigated analytically by taking into consideration the oxygen loss that occurs along the arterial microvasculature due to diffusion into the tissue and shunting to parallel running venules. The theoretical findings were related to experimental data on microvascular oxygen distribution and the blood flow weighted by the oxygen-carrying capacity of plasma and red blood cells (Q) during hemodilution. It was found that at 30-33% hematocrit, the amount of oxygen brought to the tissues is increased by 5% when diffusion is the only mechanism of oxygen loss, and by 15% when the loss is due to arteriole-venule (A-V) shunting. These increases are relative to the conditions of normal hematocrit, and are in addition to the 10% increase due to the enhancement of Q caused by hemodilution. The analysis was extended to conditions of low oxygen tension and flow condition, characteristic of ischemia. In the case of severe ischemia the total increase in oxygen delivery at hematocrit 30-33% was 38% for tissues with diffusion losses only, and 66% when shunting losses are predominant. These results suggest that hemodilution is particularly effective in increasing oxygenation in ischemic tissue, while it has a comparatively small effect in normal conditions.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Mirhashemi S,Ertefai S,Messmer K,Intaglietta Mdoi
10.1016/0026-2862(87)90062-8subject
Has Abstractpub_date
1987-11-01 00:00:00pages
290-301issue
3eissn
0026-2862issn
1095-9319journal_volume
34pub_type
杂志文章abstract::The anatomic arrangement, pressure distribution, and resting vascular tone of the feed arteries located upstream from the rat cremaster microcirculation were determined to characterize the sites of the vascular resistance in this macrovessel segment of the cremaster circulation. The cremaster microcirculation and its ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(87)90009-4
更新日期:1987-01-01 00:00:00
abstract::Alzheimer's disease (AD) is a chronic neuro-degenerative disease that adversely affect many people on a global scale. Despite different diagnostic and therapeutic treatment, there is no cure for AD. The brain is one of the most complex organ and researchers are still trying to understand so as to find a cure. OBJECTI...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103928
更新日期:2020-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1995.1038
更新日期:1995-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.04.007
更新日期:2018-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1996.0047
更新日期:1996-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1995.1025
更新日期:1995-05-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2008.08.001
更新日期:2009-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2011.04.004
更新日期:2011-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1996.0029
更新日期:1996-05-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2007.05.005
更新日期:2007-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2007.04.012
更新日期:2008-01-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.08.001
更新日期:2004-11-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2013.02.008
更新日期:2013-05-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1994.1008
更新日期:1994-01-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.02.007
更新日期:2014-05-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mvr.2011.11.002
更新日期:2012-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2018.03.004
更新日期:2018-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.mvr.2010.01.002
更新日期:2010-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103907
更新日期:2019-11-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2005.10.003
更新日期:2005-11-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(85)90040-8
更新日期:1985-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(90)90008-f
更新日期:1990-07-01 00:00:00
abstract::The fluorescence ratio imaging technique is currently applied in vitro and in vivo to measure intracellular as well as extracellular pH. To date, however, no effort has been made to assess the technique's ability to detect spatial pH gradients in vitro or in vivo, where pH gradients are known to exist, in a controlled...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1993.1048
更新日期:1993-09-01 00:00:00
abstract::An increased recognition of the role of endothelial cells in disease and the development of methods for endothelial cell culture has led to an upsurge in in vitro studies of endothelial cell function. However, the cells most often used for these studies do not reflect the in vivo heterogeneity of endothelial cells. To...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1997.2045
更新日期:1998-01-01 00:00:00
abstract::Estrogen induces endothelial progenitor cells (EPCs) migration and proliferation, which may serve as a potential target for coronary artery disease, but the mechanisms are unclear. We hypothesized that estrogen receptors (ERs) and phosphatidylinositol 3-kinase (PI3K) signaling pathway, which represent particularly imp...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2007.02.009
更新日期:2008-01-01 00:00:00
abstract::Tetrahydroxystilbene glucoside (TSG) is the main water-soluble component in Polygonum multiflorum Thunb, and it has many cardioprotective effects. Although TSG is able to relax blood vessels, its relaxation of rat superior mesenteric arteries and the underlying mechanism of this process are not clearly understood. The...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.10.007
更新日期:2019-05-01 00:00:00
abstract::Electrophysiological characteristics of cultured human umbilical vein endothelial cells (HUVEC) were determined using the patch-clamp technique in the whole cell configuration. In isolated cells, membrane potential, capacitance, and input resistance were (Mean +/- SD) - 16.3 +/- 12.7 mV, 53.9 +/- 26 pF, and 2.3 +/- 1....
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1994.1012
更新日期:1994-03-01 00:00:00
abstract::Ischemia/Reperfusion injury and hemolysis are characterized by erythrocyte lysis and release of free heme into the microcirculation. Following substantial erythrocyte lysis, heme overwhelms circulatory heme-binding protein networks rapidly forming hemin, the oxidized form of iron protoporphyrin IX. Hemin's role in mod...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2007.01.002
更新日期:2007-05-01 00:00:00
abstract::Leptin, a circulating hormone secreted mainly from adipose tissues, is involved in the control of body weight. Recently, leptin was found to be an angiogenic factor, and its vitreous levels are associated with angiogenic eye diseases such as proliferative diabetic retinopathy. However, the molecular mechanism for lept...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/s0026-2862(03)00005-0
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Sepsis is a fatal systemic inflammatory response syndrome caused by severe infection. The aim of this study was to measure hepatic microcirculation during the sepsis with laser speckle contrast imaging (LSCI), as well as investigating the underlying mechanisms. METHODS:Sepsis was induced by cecal ligation a...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.10.006
更新日期:2015-01-01 00:00:00