Abstract：
BACKGROUND:Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. OBJECTIVES:To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. METHODS:Sixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire). RESULTS:Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = -3.25, p = .02, 95% CI [-6.07, -.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN). CONCLUSION:Habitual sedentary behaviour (sitting time) appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Fenton SAM,Sandoo A,Metsios GS,Duda JL,Kitas GD,Veldhuijzen van Zanten JJCSdoi
10.1016/j.mvr.2018.01.005subject
Has Abstractpub_date
2018-05-01 00:00:00pages
57-60eissn
0026-2862issn
1095-9319pii
S0026-2862(17)30242-Xjournal_volume
117pub_type
杂志文章abstract：:The fluidity (the inverse of viscosity) of red blood cell (RBC) suspensions in vivo was estimated by means of microcirculatory measurements such as RBC flow velocity, micropressure in arterioles and venules, and vessel geometry, and by means of simultaneous macrocirculatory measurements such as volume flow and perfusi...
journal_title：Microvascular research
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更新日期：1988-01-01 00:00:00
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journal_title：Microvascular research
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更新日期：2010-09-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2007.04.008
更新日期：2007-09-01 00:00:00
abstract：:Blood flow studies in the brain, heart, and other organs suggest that there could be interaction between nitric oxide (NO) and adenosine. This possibility was investigated in the optic nerve head (ONH) during photic stimulation of the dark-adapted cat eye. Functional activation of ONH blood flow was measured by laser ...
journal_title：Microvascular research
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doi：10.1006/mvre.2002.2432
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doi：10.1016/j.mvr.2017.06.006
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journal_title：Microvascular research
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doi：10.1016/j.mvr.2016.01.005
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journal_title：Microvascular research
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journal_title：Microvascular research
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更新日期：1997-07-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2016.05.005
更新日期：2016-09-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2008.10.005
更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.mvr.2012.06.003
更新日期：2012-09-01 00:00:00
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doi：10.1016/j.mvr.2014.12.001
更新日期：2015-03-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90020-4
更新日期：1989-07-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2008.03.003
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更新日期：2006-11-01 00:00:00
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更新日期：2020-03-01 00:00:00
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更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.mvr.2012.10.005
更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0026-2862(84)90030-x
更新日期：1984-07-01 00:00:00
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更新日期：2020-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1991-03-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1996.0016
更新日期：1996-03-01 00:00:00
