Life-threatening polymyositis with spontaneous hematoma induced by nivolumab in a patient with previously resected melanoma.

abstract：:For primary melanoma, there is a delay between the initial skin biopsy and sentinel lymph node dissection, which may cause anxiety for the patient. The consequences of this delay on disease progression are unknown. The goal of this study was to determine whether delay time for sentinel node dissection from the initial...

journal_title：Melanoma research

authors： Parrett BM,Accortt NA,Li R,Dosanjh AS,Thummala S,Kullar R,Cleaver JE,Kashani-Sabet M,Leong SP

更新日期：2012-10-01 00:00:00

abstract：:Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unkno...

journal_title：Melanoma research

authors： Kalialis LV,Drzewiecki KT,Klyver H

更新日期：2009-10-01 00:00:00

abstract：:Datasets from large health maintenance organizations (HMOs), particularly those with established cancer registries that report to the Surveillance, Epidemiology, and End Results program, are potentially excellent resources for studying melanoma epidemiology and outcomes. However, generalizability of the findings beyon...

journal_title：Melanoma research

authors： Asgari MM,Eide MJ,Warton M,Fletcher SW

更新日期：2014-08-01 00:00:00

abstract：:As the cost of air travel has decreased substantially in the USA and Europe over the past few decades, leisure travel to vacation destinations during the winter months has expanded significantly. This trend has probably increased the incidence of significant ultraviolet radiation exposure and sunburn in a broader popu...

journal_title：Melanoma research

authors： Agredano YZ,Chan JL,Kimball RC,Kimball AB

更新日期：2006-02-01 00:00:00

abstract：:Anecdotal cases of partial or complete responses have been reported after ipilimumab therapy for stage IV melanoma with brain metastasis treated earlier by surgery or radiosurgery. We report the first case of ipilimumab monotherapy resulting in durable complete remission of untreated, progressive brain metastases in a...

journal_title：Melanoma research

authors： Schartz NE,Farges C,Madelaine I,Bruzzoni H,Calvo F,Hoos A,Lebbé C

更新日期：2010-06-01 00:00:00

abstract：:Concurrent BRAF-MEK inhibition improves clinical outcomes in patients with advanced BRAF V600E/K-mutant melanoma. There is currently less evidence for the efficacy of this treatment in patients with rare BRAF non-V600E/K genotypes. We report on two patients with rare BRAF exon 15 mutations - BRAF A598_T599insV and V60...

journal_title：Melanoma research

authors： Rogiers A,Vander Borght S,Tuand K,Wolter P,Stas M,Boecxstaens V,Garmyn M,van den Oord JJ,Vandenberghe P,Bechter O

更新日期：2017-10-01 00:00:00

abstract：:Occasional reports indicated cytokeratin (CK) protein expression (mainly by immunohistochemistry) in malignant melanoma (MM) and suggested an association with unfavorable clinical parameters. However, the mRNA expression of CK and its clinicopathologic significance in MM has not been specifically evaluated. We investi...

journal_title：Melanoma research

authors： Chen N,Gong J,Chen X,Xu M,Huang Y,Wang L,Geng N,Zhou Q

更新日期：2009-04-01 00:00:00

abstract：:Preoperative assessment of melanoma invasion by sonometry has been reported to exhibit a high correlation with postoperative histometry based on the determination of a regression coefficient. We believe that this approach is not adequate and that it can be misleading. We therefore applied an appropriate statistical ap...

journal_title：Melanoma research

authors： Partsch B,Binder M,Püspök-Schwarz M,Wolff K,Pehamberger H

更新日期：1996-10-01 00:00:00

abstract：:Recently, TROG 02.01 results showed that in stage III melanoma patients with nodal metastasis, adjuvant radiation to lymph node basin after nodal dissection improves lymph node field relapse without an overall survival (OS) benefit. However, this trial was neither designed nor powered to detect an OS difference. In th...

journal_title：Melanoma research

authors： Danish HH,Patel KR,Switchenko JM,Gillespie TW,Jhaveri J,Chowdhary M,Abugideiri M,Delman KA,Lawson DH,Khan MK

更新日期：2016-12-01 00:00:00

abstract：:Ipilimumab is approved for adjuvant melanoma treatment at a dose of 10 mg/kg, but its use is limited owing to high toxicity and treatment-associated costs. We retrospectively analyzed 29 patients who underwent complete resection of stage IIC-III melanoma and were treated with ipilimumab 3 mg/kg in an adjuvant setting....

journal_title：Melanoma research

authors： Mangana J,Dimitriou F,Braun R,Ludwig S,Dummer R,Barysch MJ

更新日期：2019-12-01 00:00:00

abstract：:Accumulating evidence has suggested that the XRCC1 Arg399Gln and Arg194Trp polymorphisms might be related to cutaneous melanoma susceptibility. However, epidemiologic findings have been inconsistent. We have assessed reported studies by meta-analysis to perform a more precise estimation of the association between the ...

journal_title：Melanoma research

authors： Jiang H,Xu W,Zhang F,Wei L,Wang Y,Wang Y,Liu C

更新日期：2016-06-01 00:00:00

abstract：:We studied the efficacy, tolerability and clinical courses of dabrafenib in patients with metastatic melanoma who were ineligible for enrolment into a clinical trial. Between July 2011 and May 2013, patients with unresectable stage III or stage IV, V600-mutated metastatic melanoma who were not eligible for inclusion i...

journal_title：Melanoma research

authors： Lau DK,Andrews MC,Turner N,Azad AA,Davis ID,Cebon JS

更新日期：2014-04-01 00:00:00

abstract：:In this study we evaluated the overexpression status of HER-2 and its prognostic significance on survival in patients with thick cutaneous malignant melanoma. The immuno-alkaline phosphatase antigen detection technique was applied to archival diagnostic material from 51 patients with primary lesions measuring >or= 10 ...

journal_title：Melanoma research

authors： Eliopoulos P,Mohammed MQ,Henry K,Retsas S

更新日期：2002-04-01 00:00:00

abstract：:Malignant melanoma is not only one of the most aggressive and lethal types of neoplasm, but its incidence in the general population is currently increasing at an alarming pace. It is interesting that most melanomas retain many of their characteristics of differentiation, including a dendritic nature and the production...

journal_title：Melanoma research

authors： Tsukamoto K,Gersten DM,Law LW,Hearing VJ

更新日期：1991-11-01 00:00:00

abstract：:BRAF mutations are found in ~50% of metastatic melanomas, most commonly in codon V600. Vemurafenib improves progression-free survival and overall survival in patients with advanced BRAF-mutated melanoma. The results of a descriptive study evaluating vemurafenib in patients with advanced melanoma harbouring BRAF mutati...

journal_title：Melanoma research

authors： Hallmeyer S,Gonzalez R,Lawson DH,Cranmer LD,Linette GP,Puzanov I,Taback B,Cowey CL,Ribas A,Daniels GA,Moore T,Gibney GT,Tawbi H,Whitman E,Lee G,Mun Y,Liu S,Hamid O

更新日期：2017-12-01 00:00:00

abstract：:Familial atypical multiple mole-melanoma (FAMMM) syndrome is characterized by the familial occurrence of malignant melanoma of the skin in combination with multiple atypical precursor naevi. In the present study we performed linkage analysis in seven Dutch FAMMM families to define the relationship between the ultimate...

journal_title：Melanoma research

authors： Gruis NA,Sandkuijl LA,Weber JL,van der Zee A,Borgstein AM,Bergman W,Frants RR

更新日期：1993-08-01 00:00:00

abstract：:The aim of this study was to determine the apoptotic effects, toxicity, and radiosensitization of total low dose irradiation delivered at a high dose rate in vitro to melanoma cells, normal human epidermal melanocytes (HEM), or normal human dermal fibroblasts (HDF) and to study the effect of mitochondrial inhibition i...

journal_title：Melanoma research

authors： Sarojini S,Pecora A,Milinovikj N,Barbiere J,Gupta S,Hussain ZM,Tuna M,Jiang J,Adrianzen L,Jun J,Catello L,Sanchez D,Agarwal N,Jeong S,Jin Y,Remache Y,Goy A,Ndlovu A,Ingenito A,Suh KS

更新日期：2015-10-01 00:00:00

abstract：:Many melanoma epitopes are presented to cytotoxic T-lymphocytes (CTLs) by major histocompatibility complex (MHC) class I molecules, and it is reasonable to expect that the epitopes would be good substrates for the transporter associated with antigen processing (TAP), as TAP plays a major role in the transport of pepti...

journal_title：Melanoma research

authors： Wang Y,Guttoh DS,Androlewicz MJ

更新日期：1998-08-01 00:00:00

abstract：:Tyrosinase is the key enzyme in melanin biosynthesis in pigmented cells. We transfected 9L rat glioma cells with human tyrosinase cDNA that had been cloned in a high expression vector. Stable transfectants were selected by their resistance to the antibiotic G418. More than a dozen G418-resistant clones were isolated a...

journal_title：Melanoma research

authors： Singh MV,Jimbow K

更新日期：1998-12-01 00:00:00

abstract：:The National Comprehensive Cancer Network has formulated guidelines for the management of cutaneous malignant melanoma with regard to resection margins (RMs) and regional staging. The aim of this study was to assess compliance with these recommendations in the general population of the USA. The Surveillance, Epidemiol...

journal_title：Melanoma research

authors： Wasif N,Gray RJ,Bagaria SP,Pockaj BA

更新日期：2013-08-01 00:00:00

abstract：:The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro. Up to 50% inhibition of dopachrome formation was observed in the tyrosinase-dopa reaction in the presence of t...

journal_title：Melanoma research

authors： Palumbo A,Mårs U,De Martino L,d'Ischia M,Napolitano A,Larsson BS,Prota G

更新日期：1997-12-01 00:00:00

abstract：:Levels of eumelanin (EM) and pheomelanin (PM) of uveal melanoma cells have not been measured and compared with those of normal uveal melanocytes. EM and PM amounts in four immortal human uveal melanoma cell lines were measured by chemical degradation and microanalytical high-performance liquid chromatography and compa...

journal_title：Melanoma research

authors： Hu DN,Wakamatsu K,Ito S,McCormick SA

更新日期：2009-04-01 00:00:00

abstract：:Amelanotic melanomas (AMMs) account for a small proportion of all melanomas. They pose a risk of delayed diagnosis and, consequently, poor prognosis. AMMs may atypically present as a pyogenic granuloma-like lesion. This study sought to investigate the prevalence and clinical and histological features of AMM masqueradi...

journal_title：Melanoma research

authors： Moshe M,Levi A,Ad-El D,Ben-Amitai D,Mimouni D,Didkovsky E,Feinmesser M,Lapidoth M

更新日期：2018-08-01 00:00:00

abstract：:Studies on cytogenetic abnormalities and cell lines have implicated chromosome 1p32 as being important in the pathogenesis of melanoma. Genetic linkage studies have also mapped a melanoma-susceptibility locus to chromosome 1p. The gene TAL1 is present on chromosome 1p32, and deletions within it are the commonest chrom...

journal_title：Melanoma research

authors： Chetty R,Cerroni L,Pulford K,Giatromanolaki A,Biddolph S,Kaklamanis L,Gatter K

更新日期：1995-08-01 00:00:00

abstract：:Cerebral metastases from melanoma are correlated with a poor prognosis. Temozolomide is an oral alkylating agent that can cross the blood-brain barrier and in phase II and III trials, patients with advanced metastatic melanoma achieved overall response rates of 13 to 21%. The present study evaluated the efficacy and t...

journal_title：Melanoma research

authors： Bafaloukos D,Tsoutsos D,Fountzilas G,Linardou H,Christodoulou C,Kalofonos HP,Briassoulis E,Panagiotou P,Hatzichristou H,Gogas H

更新日期：2004-08-01 00:00:00

abstract：:Interleukin-8 (IL-8) is a cytokine that is thought to promote melanoma tumour progression. We evaluated and adapted a non-radioactive, reverse transcriptase-polymerase chain reaction method for semiquantitative analysis of IL-8 mRNA expression. Using this technique we studied the regulation of IL-8 levels in the melan...

journal_title：Melanoma research

authors： Möhler T,Scheibenbogen C,Häfele J,Willhauck M,Keilholz U

更新日期：1996-08-01 00:00:00

abstract：:In order to investigate the effects of in vivo treatment with interferon-alpha (IFN-alpha) on melanoma antigens, a clinical EORTC trial (No. 18852) was accompanied by an immunohistological study. Twenty patients with melanoma metastases of skin and soft tissues, eventually also of the lung, who were treated with syste...

journal_title：Melanoma research

authors： von Stamm U,Bröcker EB,von Depka Prondzinski M,Ruiter DJ,Rümke P,Broding C,Carrel S,Lejeune FJ

更新日期：1993-06-01 00:00:00

abstract：:For the treatment of choroidal melanoma, palladium-103 (Pd) and ruthenium-106 (Ru) plaque brachytherapy shows reduced toxicity compared with the historical standard iodine-125. No report has directly compared the clinical outcomes between Pd and Ru, and the reasons for the selection of one over the other remain purely...

journal_title：Melanoma research

authors： Danish H,Ferris MJ,Balagamwala E,Switchenko JM,Patel KR,Choudhary M,Craven C,Mendoza P,Suh J,Bergstrom C,Grossniklaus HE,M Aaberg T Sr,Singh A,Crocker IR,Khan MK

更新日期：2018-04-01 00:00:00

abstract：:An inactive cathepsin B-like enzyme with a molecular mass of 40 kD was found in a human melanoma culture medium. The inactive form of this enzyme was converted into an active form with a molecular mass of 28 kD by pepsin treatment. This activated cathepsin B-like enzyme had almost the same characteristics regarding mo...

journal_title：Melanoma research

authors： Tsushima H,Hyodoh F,Yoshida E,Ueki A,Hopsu-Havu VK

更新日期：1992-01-01 00:00:00

abstract：:To investigate the diagnostic value of ultrasound-guided core needle biopsy (US-CNB) in suspected cases of lymph node metastasis from cutaneous melanoma. All patients with cutaneous melanoma followed in Saint-Louis Hospital between 2006 and 2010 who underwent US-CNB for suspicion of melanoma lymph node metastasis were...

journal_title：Melanoma research

authors： Bohelay G,Battistella M,Pagès C,de Margerie-Mellon C,Basset-Seguin N,Viguier M,Kerob D,Madjlessi N,Baccard M,Archimbaud A,Comte C,Mourah S,Porcher R,Bagot M,Janin A,De Kerviler E,Lebbé C

更新日期：2015-12-01 00:00:00