Single-center real-life experience with low-dose ipilimumab monotherapy in adjuvant setting for patients with stage III melanoma.

abstract：:Occasional reports indicated cytokeratin (CK) protein expression (mainly by immunohistochemistry) in malignant melanoma (MM) and suggested an association with unfavorable clinical parameters. However, the mRNA expression of CK and its clinicopathologic significance in MM has not been specifically evaluated. We investi...

journal_title：Melanoma research

authors： Chen N,Gong J,Chen X,Xu M,Huang Y,Wang L,Geng N,Zhou Q

更新日期：2009-04-01 00:00:00

abstract：:In this study, we aimed to evaluate the feasibility and efficacy of peptide-pulsed dendritic cell (DC) vaccine in combination with carboplatin and paclitaxel chemotherapy (DCCP) for patients with stage IV melanoma previously treated with dacarbazine-containing regimen. Six HLA-A24 and 3 HLA-A02 patients were treated w...

journal_title：Melanoma research

authors： Fukuda K,Funakoshi T,Sakurai T,Nakamura Y,Mori M,Tanese K,Tanikawa A,Taguchi J,Fujita T,Okamoto M,Amagai M,Kawakami Y

更新日期：2017-08-01 00:00:00

abstract：:Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone. The patient died of metastatic disease 3 months after the diagnosis was made. The function of the renal...

journal_title：Melanoma research

authors： Guenova E,Lichte V,Hoetzenecker W,Woelbing F,Moehrle M,Roecken M,Schaller M

更新日期：2009-08-01 00:00:00

abstract：:The correlation between ultraviolet radiation of the skin and melanoma incidence in humans is well established. Interestingly, epidemiologic data suggest also a correlation to an increased BMI pointing to metabolic trigger factors in melanoma pathogenesis. To substantiate this connection, we studied the expression of ...

journal_title：Melanoma research

authors： Kleemann J,Hrgovic I,Ter-Nedden J,Kleimann P,Steinhorst K,Härle K,Müller J,Kaufmann R,Meissner M,Kippenberger S

更新日期：2018-08-01 00:00:00

abstract：:Radiotherapy after lymph node dissection is recommended in high-risk melanoma cases. The aim of this study is to assess whether intensity-modulated radiotherapy (IMRT) offers advantages over three-dimensional conformal radiotherapy (3DCRT) in the groin nodal basin. Fifteen consecutively treated patients (5 3DCRT and 1...

journal_title：Melanoma research

authors： Adams G,Foote M,Brown S,Burmeister B

更新日期：2017-02-01 00:00:00

abstract：:The Eastern Cooperative Oncology Group consensus guidelines from 2016 recommend interruption of targeted therapy with BRAF- and MEK-inhibitors during radiotherapy with data being based mostly on BRAF monotherapy. The aim of this study is to provide data on the safety of concurrent radiotherapy and combination targeted...

journal_title：Melanoma research

authors： Ziegler JS,Kroeze S,Hilbers ML,Imhof L,Guckenberger M,Levesque MP,Dummer R,Cheng P,Mangana J

更新日期：2020-12-01 00:00:00

abstract：:Reversible oxidation sensitivity of N-Oct-3 DNA binding activity was seen when melanoma extracts and recombinant Brn-2 protein were treated with a variety of metals, hydrogen peroxide and the cysteine disulphide bond forming agent diamide. Western blot analysis of diamide-oxidized N-Oct-3 protein indicated that this w...

journal_title：Melanoma research

authors： Smith AG,Brightwell G,Smit SE,Parsons PG,Sturm RA

更新日期：1998-02-01 00:00:00

abstract：:Proteomics provides a powerful approach for screening alterations in protein expression and post-translational modification associated with particular human diseases. In this study, the analysis of protein expression was focused on malignant melanoma in order to determine the candidate genes involved in tumour progres...

journal_title：Melanoma research

authors： Carta F,Demuro PP,Zanini C,Santona A,Castiglia D,D'Atri S,Ascierto PA,Napolitano M,Cossu A,Tadolini B,Turrini F,Manca A,Sini MC,Palmieri G,Rozzo AC,Italian Melanoma Intergroup.

更新日期：2005-08-01 00:00:00

abstract：:Staging of melanoma patients by means of whole body functional imaging in a single evaluation session using positron emission tomography (PET) with fluorine-18- labelled deoxy-d-glucose (FDG) as a metabolic tracer has created much interest over the last decade. After enthusiastic pilot studies, more attention has been...

journal_title：Melanoma research

authors： Stas M,Stroobants S,Dupont P,Gysen M,Hoe LV,Garmyn M,Mortelmans L,Wever ID

更新日期：2002-10-01 00:00:00

abstract：:Metastasis is a complicated multi-step process involving interactions between tumour cells, the extracellular matrix and the vessel walls. Experimental observations suggest that leucocyte migration and function could be a suitable model in order to understand tumour cell dissemination. In the present report we show an...

journal_title：Melanoma research

authors： Bittinger F,González-García JL,Klein CL,Brochhausen C,Offner F,Kirkpatrick CJ

更新日期：1998-10-01 00:00:00

abstract：:The presence or absence of melanoma cells in human peripheral blood has recently been shown to be associated with disease prognosis, including overall survival. The detection of tyrosinase mRNA-positive circulating melanoma cells by reverse transcription-polymerase chain reaction (RT-PCR) has been limited to dissemina...

journal_title：Melanoma research

authors： Schrader AJ,Probst-Kepper M,Grosse J,Kunter U,Schenk F,Franzke A,Atzpodien J,Buer J

更新日期：2000-08-01 00:00:00

abstract：:The objective of this study is to assess the expression of heat shock protein 105 (HSP105) in melanoma and benign melanocytic lesions. The expression of HSP105 in 62 human melanoma samples--46 primary and 16 metastatic lesions--and 42 melanocytic naevi samples, was assessed by immunohistochemistry. Western blotting wa...

journal_title：Melanoma research

authors： Muchemwa FC,Nakatsura T,Fukushima S,Nishimura Y,Kageshita T,Ihn H

更新日期：2008-06-01 00:00:00

abstract：:Regional lymph nodes are affected frequently by melanoma metastasis. Its microenvironment may be associated with tumor progression. We investigated sentinel nodes with and without tumor and negative nodes surrounding positive nodes, looking for patterns related to tumor immune interaction and lymphovascular progressio...

journal_title：Melanoma research

authors： Alessi C,Scapulatempo Neto C,Viana CR,Vazquez VL

更新日期：2017-12-01 00:00:00

abstract：:Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanoc...

journal_title：Melanoma research

authors： Chavanet A,Hill KR,Jiménez-Andrade Y,Choo MK,White K,Park JM

更新日期：2020-08-01 00:00:00

abstract：:The nm23 gene is a putative tumour and metastasis suppressor gene. A number of studies have found that reduction of its expression is associated with increased metastatic potential in several human malignancies. Similarly, clinical studies have shown correlation between reduced nm23 protein expression and a poor progn...

journal_title：Melanoma research

authors： Sarris M,Scolyer RA,Konopka M,Thompson JF,Harper CG,Lee CS

更新日期：2004-02-01 00:00:00

abstract：:In several solid tumors, an increased stathmin expression is associated with both poor prognosis and resistance to certain chemotherapy types. However, the data regarding melanocytic lesions are very limited. The goals of our study are as follows: the assessment of stathmin expression in benign and malignant melanocyt...

journal_title：Melanoma research

authors： Dundr P,Simon K,Němejcová K,Bártů M,Tichá I,Michálková R,Jakša R,Věcková Z,Kodet O

更新日期：2019-04-01 00:00:00

abstract：:Immune-checkpoint inhibitors (ICIs) exposed the oncology community to novel immune-related adverse events (irAEs). Here, we report on a retrospective analysis of patients with melanoma who developed an ICI-related, unilateral, acute and peripheral facial nerve paralysis (Bell's palsy).We retrospectively reviewed all t...

journal_title：Melanoma research

authors： Beninato T,Fucà G,Di Guardo L,Vetrano I,Valeri B,Nesa F,Del Vecchio M,Cimminiello C

更新日期：2021-01-22 00:00:00

abstract：:Sentinel lymph node dissection (SLND) identifies melanoma patients with metastatic disease who would benefit from radical lymph node dissection (RLND). Rarely, patients with melanoma have an underlying lymphoproliferative disease, and melanoma metastases might develop as collision tumours in the sentinel lymph node (S...

journal_title：Melanoma research

authors： Gero D,Queiros da Mota V,Boubaker A,Berthod G,de Leval L,Demartines N,Matter M

更新日期：2014-08-01 00:00:00

abstract：:The CD10 antigen is a neutral endopeptidase expressed by a variety of mesenchymal tumours (haemopoietic or not), including a subset of malignant melanomas. We investigated the expression of CD10 in formalin-fixed, paraffin-embedded tissue specimens of 72 cutaneous melanomas (28 primary, 26 metastatic to the skin and 1...

journal_title：Melanoma research

authors： Kanitakis J,Narvaez D,Claudy A

更新日期：2002-06-01 00:00:00

abstract：:Between 1983 and 1990, 59 patients with malignant melanoma were retrospectively reviewed to assess the safety, efficacy and the maximal tolerated dose of cisplatin used in hyperthermic isolated limb perfusion. The median follow-up was 29 months (range 3-54 months). The local recurrence rate was 12% in Stage I, 33% in ...

journal_title：Melanoma research

authors： Hajarizadeh H,Mueller CR,Woltering EA,Small K,Fletcher WS

更新日期：1991-04-01 00:00:00

abstract：:Prognostic groups defined by lactate dehydrogenase concentration and number of organ sites containing metastases have been reported for patients treated with dabrafenib and trametinib for advanced melanoma. We aimed to validate these prognostic groups for patients treated with vemurafenib and cobimetinib in the coBRIM...

journal_title：Melanoma research

authors： Sorich MJ,Rowland A,Hopkins AM

更新日期：2020-06-01 00:00:00

abstract：:Interleukin-8 (IL-8) is a cytokine that is thought to promote melanoma tumour progression. We evaluated and adapted a non-radioactive, reverse transcriptase-polymerase chain reaction method for semiquantitative analysis of IL-8 mRNA expression. Using this technique we studied the regulation of IL-8 levels in the melan...

journal_title：Melanoma research

authors： Möhler T,Scheibenbogen C,Häfele J,Willhauck M,Keilholz U

更新日期：1996-08-01 00:00:00

abstract：:Ultraviolet-B (UV-B) triggers a cascade of events involving cell cycle control genes leading ultimately to DNA repair or apoptosis. The hypothesis examined here is that the genetic abnormality predisposing to melanoma affects the ability of the cell to respond appropriately to UV-B, so favouring mutagenesis. Epstein-B...

journal_title：Melanoma research

authors： Shannon JA,Kefford RF,Mann GJ

更新日期：2001-02-01 00:00:00

abstract：:Lymphoscintigraphy (LS) has been performed for 8 years in patients of the Sydney Melanoma Unit, to define lymphatic drainage patterns. Over the past 2 years, LS has also been used to locate the sentinel lymph node prior to surgery. Our technique for LS and subsequent sentinel node biopsy has an accuracy of 97%. All se...

journal_title：Melanoma research

authors： Uren RF,Howman-Giles R,Thompson JF,Shaw HM,Quinn MJ,O'Brien CJ,McCarthy WH

更新日期：1994-12-01 00:00:00

abstract：:Malignant melanoma is a cancer whose incidence is rising rapidly. Extensive studies of primary tumors and tumor-derived cell lines revealed that inappropriate activation of signal transducer and activator of transcription (STAT) proteins, particularly of STAT3 and 5, occurs with high frequency in various human cancers...

journal_title：Melanoma research

authors： Hassel JC,Winnemöller D,Schartl M,Wellbrock C

更新日期：2008-12-01 00:00:00

abstract：:Melanogenesis appears to be a unique target to develop anti-tumour agents specific for malignant melanoma. Among the anti-melanoma compounds that we have examined, 4-S-cysteaminylphenol (4-S-CAP), a phenolic amine, was found to have the most promising anti-melanoma effects. To further improve the efficacy as anti-mela...

journal_title：Melanoma research

authors： Yukitake J,Otake H,Inoue S,Wakamatsu K,Ito S

更新日期：2004-04-01 00:00:00

abstract：:An increased risk of melanoma has been variously reported in patients with chronic lymphocytic leukaemia (CLL), analogous with other immunosuppressed populations. To fully assess this association, we performed a systematic review and meta-analysis of available evidence from observational cohort studies. All such longi...

journal_title：Melanoma research

authors： Olsen CM,Lane SW,Green AC

更新日期：2016-04-01 00:00:00

abstract：:We describe a rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman. She was aware of a greyish-brown nodular lesion on the right gluteus during her first pregnancy. On histological examination, this lesion resulted to be an amelanocitic...

journal_title：Melanoma research

authors： Valenzano Menada M,Moioli M,Garaventa A,Nozza P,Foppiano M,Trimarchi N,Fulcheri E

更新日期：2010-12-01 00:00:00

abstract：:In this study we investigated the antitumour effect and mechanism of action of cationic liposome-mediated murine interferon-beta (IFNbeta) gene therapy in mouse B16F1 melanoma cells in vitro and in vivo. Murine IFNbeta gene transfer by cationic liposome resulted in substantial growth inhibition of B16F1 melanoma cells...

journal_title：Melanoma research

authors： Ryuke Y,Mizuno M,Natsume A,Suzuki O,Nobayashi M,Kageshita T,Matsumoto K,Saida T,Yoshida J

更新日期：2003-08-01 00:00:00

abstract：:Patients with melanoma may experience a variety of different vision symptoms, in part associated with melanoma-associated retinopathy. For several melanoma patients with or without melanoma-associated retinopathy, colour vision deficiencies, especially involving the tritan system, have been reported. The frequency of ...

journal_title：Melanoma research

authors： Pföhler C,Tschöp S,König J,Rass K,Tilgen W

更新日期：2006-10-01 00:00:00