Abstract：
:Amelanotic melanomas (AMMs) account for a small proportion of all melanomas. They pose a risk of delayed diagnosis and, consequently, poor prognosis. AMMs may atypically present as a pyogenic granuloma-like lesion. This study sought to investigate the prevalence and clinical and histological features of AMM masquerading as pyogenic granuloma. The database of a tertiary medical center was screened for all patients pathologically diagnosed with melanoma in 2005-2016. Those with a suspected primary (i.e. pre-excision) clinical diagnosis of pyogenic granuloma were identified, and their demographic, clinical, histologic, and outcome data were collected from the medical files. Of 2038 patients diagnosed with melanoma, 10 (∼0.5%) had a pyogenic granuloma-like AMM. The mean±SD age at lesion presentation was 56±18.9 years and the mean time from lesion appearance to diagnosis was 91.5±117.1 months. Nine tumors were located on the skin surface, and one on the oral mucosa. The mean lesion size was 19.6±14.1 mm and the mean Breslow's depth was 6.47±3.1 mm; all tumors presented in the vertical growth phase. Seven (70%) patients had lymph node involvement or metastasis at diagnosis. Two patients died of the disease within 1 year of diagnosis. Given the potential lethality of AMM and the benign nature of pyogenic granuloma, clinician recognition of pyogenic granuloma-like AMMs is crucial. In the presence of a pyogenic granuloma-like lesion, findings of older patient age and large tumor size should raise the index of suspicion and prompt a biopsy study, thereby ensuring early and accurate treatment.
journal_name
Melanoma Resjournal_title
Melanoma researchauthors
Moshe M,Levi A,Ad-El D,Ben-Amitai D,Mimouni D,Didkovsky E,Feinmesser M,Lapidoth Mdoi
10.1097/CMR.0000000000000451subject
Has Abstractpub_date
2018-08-01 00:00:00pages
363-367issue
4eissn
0960-8931issn
1473-5636journal_volume
28pub_type
杂志文章abstract：:The aim of this study was to determine the apoptotic effects, toxicity, and radiosensitization of total low dose irradiation delivered at a high dose rate in vitro to melanoma cells, normal human epidermal melanocytes (HEM), or normal human dermal fibroblasts (HDF) and to study the effect of mitochondrial inhibition i...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0000000000000174
更新日期：2015-10-01 00:00:00
abstract：:In this study we evaluated the overexpression status of HER-2 and its prognostic significance on survival in patients with thick cutaneous malignant melanoma. The immuno-alkaline phosphatase antigen detection technique was applied to archival diagnostic material from 51 patients with primary lesions measuring >or= 10 ...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/00008390-200204000-00006
更新日期：2002-04-01 00:00:00
abstract：:Our previous in vivo studies indicated that a phenolic thioether amine (PTEA), 4-S-cysteaminylphenol (CAP), selectively disintegrates melanocytes of black hair and skin, and inhibits the growth of murine and human malignant melanomas. To elucidate the mechanism of the in vivo melanocytotoxicity and anti-melanoma effec...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/00008390-199211000-00002
更新日期：1992-11-01 00:00:00
abstract：:Familial atypical multiple mole-melanoma (FAMMM) syndrome is characterized by the familial occurrence of malignant melanoma of the skin in combination with multiple atypical precursor naevi. In the present study we performed linkage analysis in seven Dutch FAMMM families to define the relationship between the ultimate...
journal_title：Melanoma research
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:Treatment of patients with metastatic uveal melanoma is very challenging because the tumor commonly spreads to the liver, surgical resection of metastases is rarely possible, and there is no standard effective systemic therapy. We report the case of a 38-year-old man, who presented with metastatic involvement of the l...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0b013e328344958c
更新日期：2011-04-01 00:00:00
abstract：:During the initiation and progression of malignant melanoma a series of genetic events accumulate, including alterations of chromosome 11q. Recently, an important tumour suppressor gene, the multiple endocrine neoplasia type 1 (MEN1) gene, has been mapped on 11q13 and has been cloned. To assess whether the MEN1 region...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/00008390-199906000-00006
更新日期：1999-06-01 00:00:00
abstract：:For the treatment of choroidal melanoma, palladium-103 (Pd) and ruthenium-106 (Ru) plaque brachytherapy shows reduced toxicity compared with the historical standard iodine-125. No report has directly compared the clinical outcomes between Pd and Ru, and the reasons for the selection of one over the other remain purely...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0000000000000420
更新日期：2018-04-01 00:00:00
abstract：:Loss of expression of E-cadherin, the major cell-cell adhesion receptor on keratinocytes, has been linked to tumour progression in various carcinomas. As E-cadherin has been reported to be expressed in cultured human melanocytes, we questioned whether loss of E-cadherin expression may also be related to melanocytic tu...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/00008390-199604000-00007
更新日期：1996-04-01 00:00:00
abstract：:Melanoma patients frequently have elevated serum levels of interleukin-6 (IL-6), which is correlated with a poor prognosis. IL-6 activates STAT3 phosphorylation, inducing the transcription of genes that regulate tumor cell proliferation and antiapoptosis. In addition, recent evidence suggests that IL-6 induces the epi...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0000000000000021
更新日期：2013-12-01 00:00:00
abstract：:Melanomas are promising targets for immunotherapy, as they express a number of tissue-specific antigens against which immune responses can be elicited. We have previously described transgenic mice in which malignant cutaneous melanomas are produced. The 1042 melanoma cell line, derived from a primary melanoma in one o...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/00008390-200412000-00019
更新日期：2004-12-01 00:00:00
abstract：:We describe a rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman. She was aware of a greyish-brown nodular lesion on the right gluteus during her first pregnancy. On histological examination, this lesion resulted to be an amelanocitic...
journal_title：Melanoma research
pub_type： 杂志文章,评审
doi：10.1097/CMR.0b013e32833faf6a
更新日期：2010-12-01 00:00:00
abstract：:A proportion of patients diagnosed with melanoma has a positive family history. Despite increasing knowledge on the genes responsible for familial clustering, the genetic basis in the majority of the families with an inherited predisposition to melanoma remains to be clarified. To identify novel melanoma-susceptibilit...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0000000000000640
更新日期：2019-12-01 00:00:00
abstract：:Staging of melanoma patients by means of whole body functional imaging in a single evaluation session using positron emission tomography (PET) with fluorine-18- labelled deoxy-d-glucose (FDG) as a metabolic tracer has created much interest over the last decade. After enthusiastic pilot studies, more attention has been...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/00008390-200209000-00010
更新日期：2002-10-01 00:00:00
abstract：:Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone. The patient died of metastatic disease 3 months after the diagnosis was made. The function of the renal...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0b013e32831bc44a
更新日期：2009-08-01 00:00:00
abstract：:Desmoplastic melanoma (DM) due to its rare and locally aggressive nature, can be difficult to study and to treat effectively. Whether the optimal treatment approach for these tumors should include adjuvant radiation has been unclear in the literature. In this retrospective study of the National Cancer Database, 2390 p...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0000000000000532
更新日期：2019-08-01 00:00:00
abstract：:Interleukin-24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) is a unique cytokine-tumor suppressor that displays ubiquitous antitumor properties and tumor-specific killing activity. Oncostatin M (OSM) is the most active IL-6-type cytokine and inhibits the proliferation of various solid tumor cell lines. M...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0000000000000038
更新日期：2014-02-01 00:00:00
abstract：:The presence of substantial amounts of GM3 ganglioside on human melanomas and other tumours, together with its peculiar biological properties, makes this glycolipid a unique target for cancer immunotherapy. B16 mouse melanoma expresses GM3 and constitutes an appropriate model for the development of novel GM3-based vac...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/00008390-200106000-00003
更新日期：2001-06-01 00:00:00
abstract：:Melanogenesis appears to be a unique target to develop anti-tumour agents specific for malignant melanoma. Among the anti-melanoma compounds that we have examined, 4-S-cysteaminylphenol (4-S-CAP), a phenolic amine, was found to have the most promising anti-melanoma effects. To further improve the efficacy as anti-mela...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/00008390-200404000-00006
更新日期：2004-04-01 00:00:00
abstract：:The goal of this study was to determine the effect of oral melatonin in divided doses on plasma melatonin levels in patients with metastatic melanoma. Hourly blood samples were obtained from five patients for 24 h prior to melatonin administration and for 24 h during oral administration of melatonin, 50 mg every 4 h. ...
journal_title：Melanoma research
pub_type： 临床试验,杂志文章
doi：10.1097/00008390-199402000-00009
更新日期：1994-02-01 00:00:00
abstract：:Glutathione (GSH) is the major non-protein thiol in cells that plays a critical role against damage from electrophilic agents such as alkylating drugs. Selective therapeutic GSH elevation in normal but not in tumour cells has been suggested as a means of protecting host tissues against more intense doses of chemothera...
journal_title：Melanoma research
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：:The liver is the predominant site of metastases in the majority of patients with uveal melanoma, suggesting the evaluation of regional treatment approaches. Here we report our experience with transarterial chemoembolization (TACE) in uveal melanoma patients with pretreated liver metastases. Twenty-five patients were t...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0b013e328334c36e
更新日期：2010-06-01 00:00:00
abstract：:The cholesterol-lowering medications, statins, inhibit cellular proliferation and induce apoptosis in an array of cancer cell lines, including melanoma. We investigated the apoptotic mechanism of lovastatin on human melanoma cell lines in vitro. The cytotoxicity of statins on multiple cell lines was examined by Cell T...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/00008390-200504000-00001
更新日期：2005-04-01 00:00:00
abstract：:Cutaneous malignant melanoma is one of the most common and aggressive forms of human cancers and has a poor prognosis. Activation of signal transducer and activator of transcription 3 (STAT3) has been found in several human cancers and is thought to correlate aggressive disease and poor response. In this study, we inv...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0b013e32834acc37
更新日期：2011-12-01 00:00:00
abstract：:Radioiodinated N-(2-(diethylamino)ethyl)benzamides have recently been discovered as selective agents for melanotic melanoma and are used for scintigraphic imaging in nuclear medicine. Owing to the high binding capacity, benzamide derivatives conjugated with alkylating cytostatics were synthesized and tested for their ...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/00008390-200410000-00004
更新日期：2004-10-01 00:00:00
abstract：:Between 1983 and 1992, 21 patients with extremity stage IIIA or IIIAB melanoma underwent hyperthermic isolation limb perfusion (HILP) with cisplatin in dosages varying from 26 to 237 mg/m2 as part of a pharmacokinetics and maximum-tolerated dose study. Extremity temperatures were up to 40 degrees C and the pH was cont...
journal_title：Melanoma research
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Ophthalmological complications constitute a class effect of treatment with BRAF inhibitors. Encorafenib is a new BRAF inhibitor currently being tested in phase 3 clinical trials for advanced or metastatic melanoma as monotherapy or in combination with the MEK-inhibitor binimetinib. In this study, we present a case of ...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0000000000000505
更新日期：2018-12-01 00:00:00
abstract：:Dermatologic toxicity is a known reaction of ipilimumab and vemurafenib. Because of the lack of effective treatments and aggressive nature of melanoma, treatments are often discontinued and new treatments are initiated in rapid succession. We report what we believe to be the first case of cumulative dermatologic toxic...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0000000000000018
更新日期：2013-12-01 00:00:00
abstract：:Melanomas contain subsets of cancer stem-like cells with tumor-initiating capacity. The frequency of these cells in the tumor is still a topic of debate. We investigated the phenotypic plasticity of cancer cells grown as melanospheres to elucidate the influence of the microenvironment on some features of melanoma stem...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0b013e3283531317
更新日期：2012-06-01 00:00:00
abstract：:The aim of the study was to identify the frequency of asymptomatic brain metastases detected by computed tomography (CT) scans in patients with metastatic cutaneous melanoma referred to first-line systemic treatment. Between 1995 and 2009, 697 Danish patients were screened with a contrast-enhanced CT scan of the brain...
journal_title：Melanoma research
pub_type： 杂志文章
doi：10.1097/CMR.0b013e32835ae915
更新日期：2013-02-01 00:00:00
abstract：:We studied the levels of serum copper and zinc as possible diagnostic factors or markers for the early detection of patients with melanoma. Levels were determined in 35 melanoma patients at various clinical stages and in 39 healthy persons. Measurements were performed by atomic absorption spectroscopy using 5100-PC-Pe...
journal_title：Melanoma research
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
