Inositol hexaphosphate plus inositol induced complete remission in stage IV melanoma: a case report.

abstract：:In a previous qualitative study it has been shown that the incorporation of pre-existing collagen bundles from the reticular dermis into the bulk of melanoma lesions metastatic to the skin indicates rapid systemic spread. In the present study the amount of pre-existing dermal collagen in the bulk of the melanoma lesio...

journal_title：Melanoma research

authors： Smolle J,Hofmann-Wellenhof R,Pfaffentaler E,Fink-Puches R,Kerl H

更新日期：1998-04-01 00:00:00

abstract：:Anorectal malignant melanoma is an uncommon tumour. Unlike for cutaneous melanoma, there are few guidelines for its optimal management. In particular, very few palliative treatment strategies have been described for patients with advanced disease. We report on an 80 year old patient with locally advanced anorectal mel...

journal_title：Melanoma research

authors： Ulmer A,Metzger S,Fierlbeck G

更新日期：2002-08-01 00:00:00

abstract：:The mechanism of action of fotemustine, a relatively new chloroethylnitrosourea, was evaluated in human melanoma cells in order to assess its potential as an agent for hyperthermic limb perfusion. Fotemustine was more toxic to O6-alkylguanine methyl transferase (AGT) deficient (Mer-) cells than Mer+ cells, implicating...

journal_title：Melanoma research

authors： Hayes MT,Bartley J,Parsons PG

更新日期：1998-02-01 00:00:00

abstract：:In tissue counter analysis, a novel image analysis tool in the evaluation of dermatoscopic images, a lattice of elementary measuring masks (elements) of equal size is randomly placed over the image and the contents of each element is evaluated by a set of colour and texture features. In this study, we tested the effic...

journal_title：Melanoma research

authors： Kahofer P,Hofmann-Wellenhof R,Smolle J

更新日期：2002-02-01 00:00:00

abstract：:Paraffin-embedded tissue from the primary tumours of 116 patients with malignant melanoma, and in 40 cases also from corresponding metastases, were examined for accumulation of p53 protein. The fraction of tumours with positive p53 immunostaining was 13% in the least invasive and 36% in the most invasive primary lesio...

journal_title：Melanoma research

authors： Flørenes VA,Holm R,Fodstad O

更新日期：1995-06-01 00:00:00

abstract：:Superficial spreading melanoma (SSM) is the most common type of melanoma. Large, population-based studies analyzing the incidence and survival of SSM are limited. This retrospective study was designed to evaluate demographic factors influencing the incidence and survival of SSM using a national population-based databa...

journal_title：Melanoma research

authors： Singh P,Kim HJ,Schwartz RA

更新日期：2016-08-01 00:00:00

abstract：:Despite the general advances in the chemotherapy of malignancies, progress comes slow in the management of patients with disseminated melanoma. Unreflected enthusiasm and frustrated scepticism are the scylla and charybdis between which the physician tries to choose the right way. ...

journal_title：Melanoma research

authors： Kleeberg UR

更新日期：1997-08-01 00:00:00

abstract：:A vaccine that could expand melanoma-specific T cells might reduce the risk of recurrence of resected melanoma and could provide an alternative or adjunct to standard immunotherapy options. We tested the safety and immunogenicity of a vaccine coupling a melanoma-associated peptide with a xenogenic peptide (to promote ...

journal_title：Melanoma research

authors： Block MS,Nevala WK,Pang YP,Allred JB,Strand C,Markovic SN

更新日期：2019-08-01 00:00:00

abstract：:Accurate staging of patients with primary cutaneous melanoma includes assessment of regional lymph nodes for the presence of micrometastatic disease. Sentinel lymph node biopsy is highly accurate but is an invasive surgical procedure with a 5-10% complication rate, and requires labour-intensive and expensive histologi...

journal_title：Melanoma research

authors： Lean CL,Bourne R,Thompson JF,Scolyer RA,Stretch J,Li LX,Russell P,Mountford C

更新日期：2003-06-01 00:00:00

abstract：:Recreational exposure to the sun may not explain fully current trends in melanoma incidence. The hypothesis was examined whether carcinogens in water play a role in the development of cutaneous melanoma. In a case-control study, 128 melanoma patients and 168 patients with other types of malignancy completed a detailed...

journal_title：Melanoma research

authors： Nelemans PJ,Rampen FH,Groenendal H,Kiemeney LA,Ruiter DJ,Verbeek AL

更新日期：1994-10-01 00:00:00

abstract：:A 58-year-old man with indolent metastatic BRAF mutant melanoma presented with several days' history of progressive ataxia and dysdiadochokinesia. His PET/computed tomography restaging scan indicated two new fluorine-18-fluorodeoxyglucose-avid mesenteric lymph nodes. Meanwhile, his MRI brain and whole spine were withi...

journal_title：Melanoma research

authors： Lee SF,Atkinson V

更新日期：2016-08-01 00:00:00

abstract：:The retinoblastoma protein (pRb) pathway is critical in regulating the G1 phase of the cell cycle and it is frequently disrupted in human cancers. Components of the pRb pathway which are often altered in tumour progression include the INK4 cyclin-dependent kinase (CDK) inhibitors p16INK4a/ CDKN2A and p15INK4b/CDKN2B, ...

journal_title：Melanoma research

authors： Rizos H,Darmanian AP,Indsto JO,Shannon JA,Kefford RF,Mann GJ

更新日期：1999-02-01 00:00:00

abstract：:Superantigens like the Staphylococcus enterotoxin A (SEA) can direct cytotoxic T lymphocytes expressing certain T cell receptor V beta regions to lyse MHC class II-positive target cells. This superantigen-dependent cellular cytotoxicity (SDCC) has been extended to MHC class II-negative tumour cells by targeting T cell...

journal_title：Melanoma research

authors： Krull F,Holzer U,Ihle J,Bethge W,Fierlbeck G,Kalland T,Dohlsten M,Niethammer D,Dannecker GE

更新日期：1997-06-01 00:00:00

abstract：:The CD10 antigen is a neutral endopeptidase expressed by a variety of mesenchymal tumours (haemopoietic or not), including a subset of malignant melanomas. We investigated the expression of CD10 in formalin-fixed, paraffin-embedded tissue specimens of 72 cutaneous melanomas (28 primary, 26 metastatic to the skin and 1...

journal_title：Melanoma research

authors： Kanitakis J,Narvaez D,Claudy A

更新日期：2002-06-01 00:00:00

abstract：:Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone. The patient died of metastatic disease 3 months after the diagnosis was made. The function of the renal...

journal_title：Melanoma research

authors： Guenova E,Lichte V,Hoetzenecker W,Woelbing F,Moehrle M,Roecken M,Schaller M

更新日期：2009-08-01 00:00:00

abstract：:During the process of melanogenesis free radicals are generated. The aim of this study was to investigate the effects of melanogenesis in B16 melanoma on lipid peroxidation and antioxidant capacity in selected tissues of black C57BL/6J mice. The study was conducted on 24 mice: 12 healthy controls and 12 with a transpl...

journal_title：Melanoma research

authors： Woźniak A,Woźniak B,Drewa G,Drewa T

更新日期：2003-02-01 00:00:00

abstract：:Immune-checkpoint inhibitors (ICIs) exposed the oncology community to novel immune-related adverse events (irAEs). Here, we report on a retrospective analysis of patients with melanoma who developed an ICI-related, unilateral, acute and peripheral facial nerve paralysis (Bell's palsy).We retrospectively reviewed all t...

journal_title：Melanoma research

authors： Beninato T,Fucà G,Di Guardo L,Vetrano I,Valeri B,Nesa F,Del Vecchio M,Cimminiello C

更新日期：2021-01-22 00:00:00

abstract：:The aim of our study was to evaluate the clinical and morphological features of primary malignant melanomas of the urinary bladder. We obtained information on five such cases from three different institutions. These were three men and two women between 52 and 76 years of age. Three tumors presented with hematuria, one...

journal_title：Melanoma research

authors： Karabulut YY,Erdogan S,Sayar H,Ergen A,Ertoy Baydar D

更新日期：2016-12-01 00:00:00

abstract：:Among patients with advanced melanoma, the development of autoimmune phenomena or of hypothyroidism during therapy has been associated with a favourable outcome. The objective of this study was to determine the prevalence of autoimmunity and of hypothyroidism in the melanoma population as a whole and to determine if t...

journal_title：Melanoma research

authors： Ellerhorst JA,Cooksley CD,Grimm EA

更新日期：2001-12-01 00:00:00

abstract：:The universal second messenger cAMP regulates numerous cellular processes. Although the cAMP-signaling pathway leads to induction of gene transcription, it remains unknown whether this pathway contributes toward suppression of transcription. Here, we show that blockade of cAMP signaling using MDL12330A led to an incre...

journal_title：Melanoma research

authors： Lakhter AJ,Naidu SR

更新日期：2017-10-01 00:00:00

abstract：:Microphthalmia transcription factor (Mitf) is involved in melanocyte development and differentiation. We previously reported that Mitf expression, as detected by immunohistochemical analysis, is an independent prognostic marker in patients with intermediate-thickness melanoma. However, the clinical significance of Mit...

journal_title：Melanoma research

authors： Naffouje S,Naffouje R,Bhagwandin S,Salti GI

更新日期：2015-12-01 00:00:00

abstract：:Pelvic sentinel lymph nodes (SLNs) are commonly identified during inguinal SLN biopsy for melanoma, but retrieval is not uniform among surgeons/centers. Few studies have assessed rates of micrometastases in pelvic versus superficial inguinal SLNs. Previous studies suggested that presence of pelvic SLNs was predicted b...

journal_title：Melanoma research

authors： Swords DS,Andtbacka RHI,Bowles TL,Hyngstrom JR

更新日期：2019-02-01 00:00:00

abstract：:M30 and M65 are relatively new assays that detect different circulating forms of the epithelial cell structural protein cytokeratin 18. This study was carried out to investigate the serum levels of M30 and M65 in patients with melanoma and the relationship with tumor progression and known prognostic parameters. Fifty-...

journal_title：Melanoma research

authors： Tas F,Karabulut S,Serilmez M,Yildiz I,Sen F,Ciftci R,Duranyildiz D

更新日期：2013-10-01 00:00:00

abstract：:Pigmented basal cell carcinoma (PBCC) is a tumour with distinct clinical features which occasionally may be difficult to differentiate from malignant melanoma (MM). The purpose of this study was to re-examine the epiluminescence microscopy (ELM) criteria for PBCC and to determine their statistical significance in the ...

journal_title：Melanoma research

authors： Püspök-Schwarz M,Steiner A,Binder M,Partsch B,Wolff K,Pehamberger H

更新日期：1997-08-01 00:00:00

abstract：:A large body of evidence in the scientific literature suggests that the numbers of common and atypical nevi are strong, independent risk factors for the occurrence of cutaneous malignant melanoma. Furthermore, some studies recently found an association between high nevus counts and an improved melanoma prognosis. The ...

journal_title：Melanoma research

authors： De Giorgi V,Scarfì F,Gori A,Maida P,Trane L,Silvestri F,Portelli F,Massi D,Covarelli P,Gandini S

更新日期：2020-04-01 00:00:00

abstract：:Primary malignant melanoma of the esophagus is an extremely rare, but highly aggressive, tumor. The prognosis for primary malignant melanoma of the esophagus remains dismal in most literatures. We report here a case of primary malignant melanoma of the esophagus that was treated by surgical resection and, additionally...

journal_title：Melanoma research

authors： Yang X,Qu J,Wang S

更新日期：2010-02-01 00:00:00

abstract：:Between 1983 and 1990, 59 patients with malignant melanoma were retrospectively reviewed to assess the safety, efficacy and the maximal tolerated dose of cisplatin used in hyperthermic isolated limb perfusion. The median follow-up was 29 months (range 3-54 months). The local recurrence rate was 12% in Stage I, 33% in ...

journal_title：Melanoma research

authors： Hajarizadeh H,Mueller CR,Woltering EA,Small K,Fletcher WS

更新日期：1991-04-01 00:00:00

abstract：:Putative tumour suppressor genes CDKN2A and CDKN2B (on chromosome 9p21) and CDKN2A-interacting cell growth regulatory genes CDK4 and Id-1 have been demonstrated to be involved in the pathogenesis of malignant melanoma (MM). Mutation analysis of these candidate genes was performed in MM families from southern Italy wit...

journal_title：Melanoma research

authors： Casula M,Ascierto PA,Cossu A,Sini MC,Tore S,Colombino M,Satta MP,Manca A,Rozzo C,Satriano SM,Castello G,Lissia A,Tanda F,Palmieri G

更新日期：2003-12-01 00:00:00

abstract：:Prognostic blood biomarkers for patients with uveal melanoma have not been identified. Tumor monosomy-3 is strongly associated with the development of metastatic disease. Tumor expression of human leukocyte antigen class I molecules and insulin-like growth factor (IGF)-1 receptor has also been associated with the deve...

journal_title：Melanoma research

authors： Triozzi PL,Elson P,Aldrich W,Achberger S,Tubbs R,Biscotti CV,Singh AD

更新日期：2013-02-01 00:00:00

abstract：:Uveal melanoma is a rare form of melanoma and the most frequent primary eye malignancy in adults. The major molecular alterations underlying uveal melanoma pathogenesis affect mainly the GNAQ, GNA11, SF3B1, and BAP1 genes. In this study, we somatically genotyped 31 Brazilian uveal melanomas for BRAF, GNA11, GNAQ, SF3B...

journal_title：Melanoma research

authors： Sarubi HC,Pereira NB,Gomes CC,Gomez RS,Carmo ACM,Melo FM,Bastos-Rodrigues L,Pedrosa MS,Friedman E,De Marco L

更新日期：2019-06-01 00:00:00