Expression and clinical significance of S100 family genes in patients with melanoma.

abstract：:The growth rate (GR) of melanomas is not uniform. A fast-growing subtype has been identified and seems to have a role in the stabilization of the mortality rates because of melanoma. To examine features associated with fast-growing melanomas (FGMs) and to determine the relationship between the GR and well-recognized p...

journal_title：Melanoma research

authors： Martorell-Calatayud A,Nagore E,Botella-Estrada R,Scherer D,Requena C,Serra-Guillén C,Llombart B,Sanmartin O,Kumar R,Guillén C

更新日期：2011-04-01 00:00:00

abstract：:The occurrence of cancer in pregnant women is not a common phenomenon and the real incidence of malignant melanoma during this period is unknown. Many authors reported a poor prognosis in pregnant women with melanoma compared with non-pregnant women's tumour. Several retrospective reviews reported a worsened prognosis...

journal_title：Melanoma research

authors： Silipo V,De Simone P,Mariani G,Buccini P,Ferrari A,Catricala C

更新日期：2006-12-01 00:00:00

abstract：:The aim of the study was to identify the frequency of asymptomatic brain metastases detected by computed tomography (CT) scans in patients with metastatic cutaneous melanoma referred to first-line systemic treatment. Between 1995 and 2009, 697 Danish patients were screened with a contrast-enhanced CT scan of the brain...

journal_title：Melanoma research

authors： Zukauskaite R,Schmidt H,Asmussen JT,Hansen O,Bastholt L

更新日期：2013-02-01 00:00:00

abstract：:As the cost of air travel has decreased substantially in the USA and Europe over the past few decades, leisure travel to vacation destinations during the winter months has expanded significantly. This trend has probably increased the incidence of significant ultraviolet radiation exposure and sunburn in a broader popu...

journal_title：Melanoma research

authors： Agredano YZ,Chan JL,Kimball RC,Kimball AB

更新日期：2006-02-01 00:00:00

abstract：:Electrochemotherapy (ECT), chemotherapy administered in combination with electric fields, has the potential to be an effective localized treatment for cutaneous malignancies. Bleomycin's cytotoxicity was enhanced by exposing tumour cells to electrical fields following intravenous injection of the chemotherapeutic agen...

journal_title：Melanoma research

authors： Heller R,Jaroszeski M,Perrott R,Messina J,Gilbert R

更新日期：1997-02-01 00:00:00

abstract：:The aim of this study was to present the epidemiological, clinicopathological, and treatment characteristics of patients diagnosed and treated in a tertiary referral center and to analyze independent factors associated with these characteristics. In this cohort study, epidemiological, clinicopathological, and treatmen...

journal_title：Melanoma research

authors： Tsoutsos D,Papadopoulos S,Kehagias G,Mara A,Kyriopoulou E,Karonidis A,Spiliopoulos K,Mpalitsaris E,Karapiperis G,Panayotou P,Papaliodi E,Choreftaki T,Papaxoinis G,Benopoulou O,Ioannovich J,Gogas H

更新日期：2018-08-01 00:00:00

abstract：:In patients with metastatic cancer, gut microbiome composition differs between responder and non-responders to immune checkpoint inhibitors. However, there is little consensus on the microbiome taxa associated with response or lack of response. Additionally, recognized confounders of gut microbiome composition have ge...

journal_title：Melanoma research

authors： Wind TT,Gacesa R,Vich Vila A,de Haan JJ,Jalving M,Weersma RK,Hospers GAP

更新日期：2020-06-01 00:00:00

abstract：:The incidence of melanoma has increased continuously during the last decade. Surgery is the mainstay of therapy but, for patients with thick lesions or regional metastatic lymph nodes, there is a high risk of relapse. For this group of patients, there is no standard therapy or general agreement amongst oncologists. In...

journal_title：Melanoma research

authors： Queirolo P,Acquati M,Kirkwood JM,Eggermont AM,Rocca A,Testori A

更新日期：2005-10-01 00:00:00

abstract：:Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanoc...

journal_title：Melanoma research

authors： Chavanet A,Hill KR,Jiménez-Andrade Y,Choo MK,White K,Park JM

更新日期：2020-08-01 00:00:00

abstract：:The presence of substantial amounts of GM3 ganglioside on human melanomas and other tumours, together with its peculiar biological properties, makes this glycolipid a unique target for cancer immunotherapy. B16 mouse melanoma expresses GM3 and constitutes an appropriate model for the development of novel GM3-based vac...

journal_title：Melanoma research

authors： Carr A,Mazorra Z,Alonso DF,Mesa C,Valiente O,Gomez DE,Perez R,Fernandez LE

更新日期：2001-06-01 00:00:00

abstract：:We assessed the risk of cutaneous malignant melanoma associated with the presence of ovulatory abnormalities and with the use of ovulation-inducing agents (such as clomiphene citrate) in a cohort of 3,837 women evaluated at infertility clinics in Seattle, WA, between 1974 and 1985. Computer linkage with a population-b...

journal_title：Melanoma research

authors： Rossing MA,Daling JR,Weiss NS,Moore DE,Self SG

更新日期：1995-04-01 00:00:00

abstract：:Cutaneous malignant melanoma is one of the most common and aggressive forms of human cancers and has a poor prognosis. Activation of signal transducer and activator of transcription 3 (STAT3) has been found in several human cancers and is thought to correlate aggressive disease and poor response. In this study, we inv...

journal_title：Melanoma research

authors： Wu ZS,Cheng XW,Wang XN,Song NJ

更新日期：2011-12-01 00:00:00

abstract：:In several solid tumors, an increased stathmin expression is associated with both poor prognosis and resistance to certain chemotherapy types. However, the data regarding melanocytic lesions are very limited. The goals of our study are as follows: the assessment of stathmin expression in benign and malignant melanocyt...

journal_title：Melanoma research

authors： Dundr P,Simon K,Němejcová K,Bártů M,Tichá I,Michálková R,Jakša R,Věcková Z,Kodet O

更新日期：2019-04-01 00:00:00

abstract：:In a previous qualitative study it has been shown that the incorporation of pre-existing collagen bundles from the reticular dermis into the bulk of melanoma lesions metastatic to the skin indicates rapid systemic spread. In the present study the amount of pre-existing dermal collagen in the bulk of the melanoma lesio...

journal_title：Melanoma research

authors： Smolle J,Hofmann-Wellenhof R,Pfaffentaler E,Fink-Puches R,Kerl H

更新日期：1998-04-01 00:00:00

abstract：:Between 1983 and 1990, 59 patients with malignant melanoma were retrospectively reviewed to assess the safety, efficacy and the maximal tolerated dose of cisplatin used in hyperthermic isolated limb perfusion. The median follow-up was 29 months (range 3-54 months). The local recurrence rate was 12% in Stage I, 33% in ...

journal_title：Melanoma research

authors： Hajarizadeh H,Mueller CR,Woltering EA,Small K,Fletcher WS

更新日期：1991-04-01 00:00:00

abstract：:Occasional reports indicated cytokeratin (CK) protein expression (mainly by immunohistochemistry) in malignant melanoma (MM) and suggested an association with unfavorable clinical parameters. However, the mRNA expression of CK and its clinicopathologic significance in MM has not been specifically evaluated. We investi...

journal_title：Melanoma research

authors： Chen N,Gong J,Chen X,Xu M,Huang Y,Wang L,Geng N,Zhou Q

更新日期：2009-04-01 00:00:00

abstract：:The management of metastatic melanoma is a difficult matter. Nevertheless, the advent of target therapy has significantly improved patient outcome, provided that tumor molecular characteristics become available: the detection of drug-resistant clones can contribute to understanding the reasons for resistance onset, in...

journal_title：Melanoma research

authors： Scaini MC,Pigozzo J,Pizzi M,Manicone M,Chiarion-Sileni V,Zambenedetti P,Rugge M,Zanovello P,Rossi E,Zamarchi R,Facchinetti A

更新日期：2019-02-01 00:00:00

abstract：:Immune checkpoint inhibitors targeting the programmed cell death (PD)-1 receptor have dramatically changed the landscape of metastatic melanoma treatment. Nevertheless, these immuno-modulatory agents have associated side effects, including dermatologic manifestations. To this end, we report a patient with metastatic m...

journal_title：Melanoma research

authors： Rambhia PH,Honda K,Arbesman J

更新日期：2018-10-01 00:00:00

abstract：:This randomized phase II trial was performed to define the activity and toxicity of the combination of dacarbazine (DTIC), carmustine (BCNU), cisplatin (DDP) and tamoxifen (DBDT regimen) versus DTIC alone in patients with metastatic melanoma. Sixty patients with metastatic melanoma were randomly assigned to receive BC...

journal_title：Melanoma research

authors： Chiarion Sileni V,Nortilli R,Aversa SM,Paccagnella A,Medici M,Corti L,Favaretto AG,Cetto GL,Monfardini S

更新日期：2001-04-01 00:00:00

abstract：:Accumulating evidence has suggested that the XRCC1 Arg399Gln and Arg194Trp polymorphisms might be related to cutaneous melanoma susceptibility. However, epidemiologic findings have been inconsistent. We have assessed reported studies by meta-analysis to perform a more precise estimation of the association between the ...

journal_title：Melanoma research

authors： Jiang H,Xu W,Zhang F,Wei L,Wang Y,Wang Y,Liu C

更新日期：2016-06-01 00:00:00

abstract：:Uveal melanoma is a rare form of melanoma and the most frequent primary eye malignancy in adults. The major molecular alterations underlying uveal melanoma pathogenesis affect mainly the GNAQ, GNA11, SF3B1, and BAP1 genes. In this study, we somatically genotyped 31 Brazilian uveal melanomas for BRAF, GNA11, GNAQ, SF3B...

journal_title：Melanoma research

authors： Sarubi HC,Pereira NB,Gomes CC,Gomez RS,Carmo ACM,Melo FM,Bastos-Rodrigues L,Pedrosa MS,Friedman E,De Marco L

更新日期：2019-06-01 00:00:00

abstract：:Melanoma is the most lethal skin tumor in large part because of a propensity for early metastasis. Good models of this most clinically relevant feature of melanoma are lacking. Here, we report the development of an in-vivo model of metastasis that relies on orthotopic injection of green fluorescent protein-tagged line...

journal_title：Melanoma research

authors： Rozenberg GI,Monahan KB,Torrice C,Bear JE,Sharpless NE

更新日期：2010-10-01 00:00:00

abstract：:Prognostic groups defined by lactate dehydrogenase concentration and number of organ sites containing metastases have been reported for patients treated with dabrafenib and trametinib for advanced melanoma. We aimed to validate these prognostic groups for patients treated with vemurafenib and cobimetinib in the coBRIM...

journal_title：Melanoma research

authors： Sorich MJ,Rowland A,Hopkins AM

更新日期：2020-06-01 00:00:00

abstract：:Between 6 and 14% of malignant melanomas have been reported to occur in a familial pattern. In this study 785 melanoma patients from the Victorian Melanoma Service and the private practice of a dermatologist were assessed for the total number of melanocytic naevi, the number of dysplastic naevi and other clinical char...

journal_title：Melanoma research

authors： Ang CG,Kelly JW,Fritschi L,Dowling JP

更新日期：1998-10-01 00:00:00

abstract：:Datasets from large health maintenance organizations (HMOs), particularly those with established cancer registries that report to the Surveillance, Epidemiology, and End Results program, are potentially excellent resources for studying melanoma epidemiology and outcomes. However, generalizability of the findings beyon...

journal_title：Melanoma research

authors： Asgari MM,Eide MJ,Warton M,Fletcher SW

更新日期：2014-08-01 00:00:00

abstract：:The objective of this study is to assess the expression of heat shock protein 105 (HSP105) in melanoma and benign melanocytic lesions. The expression of HSP105 in 62 human melanoma samples--46 primary and 16 metastatic lesions--and 42 melanocytic naevi samples, was assessed by immunohistochemistry. Western blotting wa...

journal_title：Melanoma research

authors： Muchemwa FC,Nakatsura T,Fukushima S,Nishimura Y,Kageshita T,Ihn H

更新日期：2008-06-01 00:00:00

abstract：:Treatment strategies for metastatic melanoma have changed markedly in recent times due to the advent of targeted systemic therapies. In addition to these developments, surgery remains a useful adjunct that can confer survival benefits in selected patients. In this review, we examine the current literature to highlight...

journal_title：Melanoma research

authors： O'Leary DP,Byrnes KG,Power DG,Redmond HP

更新日期：2015-02-01 00:00:00

abstract：:The aim of this study was to evaluate the accuracy of a computer-based system for the automated diagnosis of melanoma in the hands of nonexpert physicians. We performed a prospective comparison between nonexperts using computer assistance and experts without assistance in the setting of a tertiary referral center at a...

journal_title：Melanoma research

authors： Dreiseitl S,Binder M,Hable K,Kittler H

更新日期：2009-06-01 00:00:00

abstract：:In this study, we aimed to evaluate the feasibility and efficacy of peptide-pulsed dendritic cell (DC) vaccine in combination with carboplatin and paclitaxel chemotherapy (DCCP) for patients with stage IV melanoma previously treated with dacarbazine-containing regimen. Six HLA-A24 and 3 HLA-A02 patients were treated w...

journal_title：Melanoma research

authors： Fukuda K,Funakoshi T,Sakurai T,Nakamura Y,Mori M,Tanese K,Tanikawa A,Taguchi J,Fujita T,Okamoto M,Amagai M,Kawakami Y

更新日期：2017-08-01 00:00:00

abstract：:Among patients with advanced melanoma, the development of autoimmune phenomena or of hypothyroidism during therapy has been associated with a favourable outcome. The objective of this study was to determine the prevalence of autoimmunity and of hypothyroidism in the melanoma population as a whole and to determine if t...

journal_title：Melanoma research

authors： Ellerhorst JA,Cooksley CD,Grimm EA

更新日期：2001-12-01 00:00:00