Abstract:
:Immune checkpoint inhibitors targeting the programmed cell death (PD)-1 receptor have dramatically changed the landscape of metastatic melanoma treatment. Nevertheless, these immuno-modulatory agents have associated side effects, including dermatologic manifestations. To this end, we report a patient with metastatic melanoma that was treated with a PD-1 inhibitor, and subsequently developed inflammation of existing seborrheic keratosis lesions and new verrucous keratoses, a cutaneous side effect that has not been previously reported to our knowledge. The etiology of seborrheic and verrucous keratoses is not well understood, although their physical and histopathologic similarities to chronic viral-derived lesions, such as human papilloma virus, suggest a potential viral association. Chronic viral infections are known to result in T-cell tolerance because of persistent antigen stimulation. PD-1 inhibition is able to reinvigorate exhausted T cells, which are accordingly able to decrease viral load. Thus, the inflammatory reaction, seen in our patient, may be the result of PD-1 inhibition reactivating virally driven T lymphocytes.
journal_name
Melanoma Resjournal_title
Melanoma researchauthors
Rambhia PH,Honda K,Arbesman Jdoi
10.1097/CMR.0000000000000477subject
Has Abstractpub_date
2018-10-01 00:00:00pages
475-477issue
5eissn
0960-8931issn
1473-5636journal_volume
28pub_type
杂志文章abstract::The cell surface glycoprotein MUC18 was originally identified as a progression associated antigen in melanoma. MUC18 is expressed most strongly on metastatic lesions and advanced primary tumours and is only rarely detected in benign lesions. cDNA cloning revealed MUC18 to be a novel member of the immunoglobulin superf...
journal_title:Melanoma research
pub_type: 杂志文章,评审
doi:10.1097/00008390-199310000-00006
更新日期:1993-10-01 00:00:00
abstract::Primary malignant melanoma of the esophagus is an extremely rare, but highly aggressive, tumor. The prognosis for primary malignant melanoma of the esophagus remains dismal in most literatures. We report here a case of primary malignant melanoma of the esophagus that was treated by surgical resection and, additionally...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3283307c8a
更新日期:2010-02-01 00:00:00
abstract::The occurrence of cancer in pregnant women is not a common phenomenon and the real incidence of malignant melanoma during this period is unknown. Many authors reported a poor prognosis in pregnant women with melanoma compared with non-pregnant women's tumour. Several retrospective reviews reported a worsened prognosis...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/01.cmr.0000232295.91536.09
更新日期:2006-12-01 00:00:00
abstract::Dissemination of uveal melanomas is almost exclusively haematogenous, making angiogenesis of the tumour a prerequisite for the formation of metastases. Uveal melanomas must employ strategies to evade the immune system in order to escape immune surveillance. We therefore determined the expression of the following angio...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199910000-00003
更新日期:1999-10-01 00:00:00
abstract::One of the principal applications of tumour markers is the early detection of recurrent disease in the follow-up of patients. In the study described here, we compared the usefulness of two serum markers for melanoma, 5-S-cysteinyldopa (5-S-CD) and melanoma inhibitory activity (MIA), in the monitoring of postsurgical m...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200208000-00003
更新日期:2002-08-01 00:00:00
abstract::Loss of expression of E-cadherin, the major cell-cell adhesion receptor on keratinocytes, has been linked to tumour progression in various carcinomas. As E-cadherin has been reported to be expressed in cultured human melanocytes, we questioned whether loss of E-cadherin expression may also be related to melanocytic tu...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199604000-00007
更新日期:1996-04-01 00:00:00
abstract::Protein tyrosyl phosphorylation is an essential component in intracellular signalling, with diverse and crucial functions including mediation of cell proliferation, survival, death, differentiation, migration and attachment. It is regulated by the balance between the activities of protein tyrosine kinases (PTKs) and p...
journal_title:Melanoma research
pub_type: 杂志文章,评审
doi:10.1097/00008390-200010000-00001
更新日期:2000-10-01 00:00:00
abstract::There is no general consensus regarding the optimal follow-up strategy for patients with melanoma. We sought to determine the utility and cost effectiveness of radiological restaging of patients with stage IIB-IIIC melanoma at the 3-year follow-up time point. A retrospective review of 210 patients diagnosed with stage...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3283471086
更新日期:2011-08-01 00:00:00
abstract::The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro. Up to 50% inhibition of dopachrome formation was observed in the tyrosinase-dopa reaction in the presence of t...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199712000-00006
更新日期:1997-12-01 00:00:00
abstract::The EORTC Melanoma Cooperative Group conducted a phase II trial (study number 18891) to study the effect of Toremifene in 45 patients with advanced, metastatic melanoma. Male and female patients, median age 61 (range 23-88) years received a mean total dose of 11 g (4.3-62.6) orally for at least 6 weeks. No objective r...
journal_title:Melanoma research
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1993-04-01 00:00:00
abstract::MicroRNAs (miRNAs) are small noncoding RNA molecules involved in gene regulation. Aberrant expression of miRNA has been associated with the development or progression of several diseases, including cancer. In a previous study, we found that the expression of miRNA-125b (miR-125b) was two-fold lower in malignant melano...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e328345333b
更新日期:2011-06-01 00:00:00
abstract::Treatment of patients with metastatic melanoma with either dacarbazine (DTIC) or interferon-alpha (IFNalpha) as single drugs, or in combination, results in a response rate of approximately 15-20%. This study evaluated the activity and toxicity following treatment with a combination of DTIC, IFNalpha2b and verapamil (V...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200302000-00014
更新日期:2003-02-01 00:00:00
abstract::In metastatic melanoma (MM) immunomodulating agents, such as interleukin-2 (IL-2) and interferon-α (IFN-α), have shown therapeutic benefit as they enhance antitumor immune response. Considering tumor-induced suppression of natural killer (NK) cell activity, it is of interest to study the affect of these cytokines on t...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e32833e3286
更新日期:2010-12-01 00:00:00
abstract::BRAF mutations are found in ~50% of metastatic melanomas, most commonly in codon V600. Vemurafenib improves progression-free survival and overall survival in patients with advanced BRAF-mutated melanoma. The results of a descriptive study evaluating vemurafenib in patients with advanced melanoma harbouring BRAF mutati...
journal_title:Melanoma research
pub_type: 杂志文章,多中心研究
doi:10.1097/CMR.0000000000000398
更新日期:2017-12-01 00:00:00
abstract::For primary melanoma, there is a delay between the initial skin biopsy and sentinel lymph node dissection, which may cause anxiety for the patient. The consequences of this delay on disease progression are unknown. The goal of this study was to determine whether delay time for sentinel node dissection from the initial...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e32835861f6
更新日期:2012-10-01 00:00:00
abstract::Anorectal malignant melanoma is an uncommon tumour. Unlike for cutaneous melanoma, there are few guidelines for its optimal management. In particular, very few palliative treatment strategies have been described for patients with advanced disease. We report on an 80 year old patient with locally advanced anorectal mel...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200208000-00013
更新日期:2002-08-01 00:00:00
abstract::CD8 T-cell infiltration of metastatic melanoma may be a useful biomarker for prediction of prognosis and response to therapy. The heterogeneous distribution of CD8 T cells within a single tumor, and across different tumors within a single patient, may complicate quantification of infiltration. However, the impact of h...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000330
更新日期:2017-06-01 00:00:00
abstract::Ipilimumab, a fully human, recombinant, monoclonal antibody to cytotoxic T-lymphocyte antigen 4 improves overall survival (OS) in previously treated and untreated metastatic melanoma. This retrospective analysis reports data gathered by a questionnaire on the demographics, outcomes, and toxicity of ipilimumab administ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000108
更新日期:2014-12-01 00:00:00
abstract::The p53 pathway regulates stress response, and variations in p53, MDM2, and MDM4 may predispose an individual to tumor development. The aim of this study was to study the impact of genetic variation on sporadic and hereditary melanoma. We have analyzed a combination of three functionally relevant variants of the p53 p...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000063
更新日期:2014-06-01 00:00:00
abstract::Prognostic groups defined by lactate dehydrogenase concentration and number of organ sites containing metastases have been reported for patients treated with dabrafenib and trametinib for advanced melanoma. We aimed to validate these prognostic groups for patients treated with vemurafenib and cobimetinib in the coBRIM...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000634
更新日期:2020-06-01 00:00:00
abstract::Ophthalmological complications constitute a class effect of treatment with BRAF inhibitors. Encorafenib is a new BRAF inhibitor currently being tested in phase 3 clinical trials for advanced or metastatic melanoma as monotherapy or in combination with the MEK-inhibitor binimetinib. In this study, we present a case of ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000505
更新日期:2018-12-01 00:00:00
abstract::Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. It has been shown to inhibit the growth of many different tumor cell lines both in vitro and in vivo like colon, pancreas, liver, prostate, and even melan...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000577
更新日期:2019-06-01 00:00:00
abstract::Tumor cell invasion through basement membranes and into stromal tissue are key steps for promoting growth and metastasis. Tumor cells express various extracellular-matrix-degrading enzymes such as matrix metalloproteinases (MMPs) to degrade extracellular matrix components to facilitate tumor migration and invasion. Hi...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3282a660ad
更新日期:2007-08-01 00:00:00
abstract::The presence or absence of melanoma cells in human peripheral blood has recently been shown to be associated with disease prognosis, including overall survival. The detection of tyrosinase mRNA-positive circulating melanoma cells by reverse transcription-polymerase chain reaction (RT-PCR) has been limited to dissemina...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200008000-00007
更新日期:2000-08-01 00:00:00
abstract::Radioiodinated N-(2-(diethylamino)ethyl)benzamides have recently been discovered as selective agents for melanotic melanoma and are used for scintigraphic imaging in nuclear medicine. Owing to the high binding capacity, benzamide derivatives conjugated with alkylating cytostatics were synthesized and tested for their ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200410000-00004
更新日期:2004-10-01 00:00:00
abstract::In this study, we aimed to evaluate the feasibility and efficacy of peptide-pulsed dendritic cell (DC) vaccine in combination with carboplatin and paclitaxel chemotherapy (DCCP) for patients with stage IV melanoma previously treated with dacarbazine-containing regimen. Six HLA-A24 and 3 HLA-A02 patients were treated w...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000342
更新日期:2017-08-01 00:00:00
abstract::We studied the response of mouse B16F10 and SK-MEL-28 and SK-MEL-1 human melanoma cell lines to treatment with 4-hydroxyanisole (4-HA), and attempted to relate the response to the dopa oxidase levels and the morphological characteristics of each cell line. Clear dose-response curves were observed after 24 h of treatme...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199710000-00003
更新日期:1997-10-01 00:00:00
abstract::As the cost of air travel has decreased substantially in the USA and Europe over the past few decades, leisure travel to vacation destinations during the winter months has expanded significantly. This trend has probably increased the incidence of significant ultraviolet radiation exposure and sunburn in a broader popu...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/01.cmr.0000195696.50390.23
更新日期:2006-02-01 00:00:00
abstract::We studied the levels of serum copper and zinc as possible diagnostic factors or markers for the early detection of patients with melanoma. Levels were determined in 35 melanoma patients at various clinical stages and in 39 healthy persons. Measurements were performed by atomic absorption spectroscopy using 5100-PC-Pe...
journal_title:Melanoma research
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Patients with brain metastases (BM) from melanoma have an overall survival (OS) of 2-6 months after whole-brain radiotherapy. Targeted therapy (TT) is an effective treatment for BRAF-mutated metastatic melanoma. Moreover, recent studies indicate intracranial responses of TT in patients with BM. We analyzed 146 patient...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000429
更新日期:2018-04-01 00:00:00