Abstract:
:Ophthalmological complications constitute a class effect of treatment with BRAF inhibitors. Encorafenib is a new BRAF inhibitor currently being tested in phase 3 clinical trials for advanced or metastatic melanoma as monotherapy or in combination with the MEK-inhibitor binimetinib. In this study, we present a case of severe bilateral panuveitis and neurosensory hearing loss in an elderly patient treated with encorafenib and binimetinib for metastatic BRAF-mutant melanoma. This constellation of findings is compatible with incomplete Vogt-Koyanagi-Harada (VKH) disease. VKH disease is a rare multisystem disease characterized by granulomatous panuveitis, serous retinal detachments, and neurologic and dermatologic manifestations. In patients with melanoma, its emergence has been correlated to a favorable prognosis of the underlying melanoma by several authors. The patient reported here had a severe panuveitis and bilateral retinal detachments causing permanent visual impairment. She was treated with a long course of systemic corticosteroids, but at the same time, she achieved complete remission of the melanoma lasting for 26 months after permanent encorafenib and binimetinib discontinuation, without further antineoplastic treatment. VKH disease is a rare entity and the need for interdisciplinary cooperation for its diagnosis in patients with melanoma and uveitis is emphasized.
journal_name
Melanoma Resjournal_title
Melanoma researchauthors
Diamantopoulos PT,Stoungioti S,Anastasopoulou A,Papaxoinis G,Gogas Hdoi
10.1097/CMR.0000000000000505subject
Has Abstractpub_date
2018-12-01 00:00:00pages
648-651issue
6eissn
0960-8931issn
1473-5636journal_volume
28pub_type
杂志文章abstract::Ipilimumab, a fully human, recombinant, monoclonal antibody to cytotoxic T-lymphocyte antigen 4 improves overall survival (OS) in previously treated and untreated metastatic melanoma. This retrospective analysis reports data gathered by a questionnaire on the demographics, outcomes, and toxicity of ipilimumab administ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000108
更新日期:2014-12-01 00:00:00
abstract::Selective BRAF inhibitors (BRAFi) yield objective responses in 50% of patients with metastatic BRAF V600E mutant melanoma. Adding an MEK inhibitor increases this response rate to 70%. Limited data are available on the outcomes of unresectable stage III patients, and it remains unclear whether BRAF-targeted therapy can...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000214
更新日期:2016-02-01 00:00:00
abstract::The National Comprehensive Cancer Network has formulated guidelines for the management of cutaneous malignant melanoma with regard to resection margins (RMs) and regional staging. The aim of this study was to assess compliance with these recommendations in the general population of the USA. The Surveillance, Epidemiol...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e32836254bd
更新日期:2013-08-01 00:00:00
abstract::Several hypotheses have explicitly implicated the role of an altered redox status of melanin in the aetiology of melanoma and macular degeneration. The balance between the intrinsic anti-oxidant and pro-oxidant properties of melanin is lost, resulting in an altered redox phenotype. We propose that such an alteration o...
journal_title:Melanoma research
pub_type: 杂志文章,评审
doi:10.1097/01.cmr.0000195699.35143.df
更新日期:2006-02-01 00:00:00
abstract::The aim of this study was to present the epidemiological, clinicopathological, and treatment characteristics of patients diagnosed and treated in a tertiary referral center and to analyze independent factors associated with these characteristics. In this cohort study, epidemiological, clinicopathological, and treatmen...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000456
更新日期:2018-08-01 00:00:00
abstract::Germline mutations determining increased cutaneous malignant melanoma (CMM) risk have been identified in familial and sporadic CMM cases, but they account only for a small proportion of CMM cases. Recent evidence suggests that germline epimutations (e.g. DNA methylation alterations), which can be inherited similarly t...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000112
更新日期:2014-10-01 00:00:00
abstract::Lysosome-associated membrane protein-1 is a protein with a significant content of beta1,6-branched N-glycans. It is thought that enhanced expression of lysosome-associated membrane protein-1 in tumour cells may promote invasion by influencing both adhesion to extracellular matrix and perhaps also binding to endothelia...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/01.cmr.0000215034.00318.7a
更新日期:2006-06-01 00:00:00
abstract::There is no general consensus regarding the optimal follow-up strategy for patients with melanoma. We sought to determine the utility and cost effectiveness of radiological restaging of patients with stage IIB-IIIC melanoma at the 3-year follow-up time point. A retrospective review of 210 patients diagnosed with stage...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3283471086
更新日期:2011-08-01 00:00:00
abstract::Sentinel lymph node dissection (SLND) identifies melanoma patients with metastatic disease who would benefit from radical lymph node dissection (RLND). Rarely, patients with melanoma have an underlying lymphoproliferative disease, and melanoma metastases might develop as collision tumours in the sentinel lymph node (S...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000098
更新日期:2014-08-01 00:00:00
abstract::Among patients with advanced melanoma, the development of autoimmune phenomena or of hypothyroidism during therapy has been associated with a favourable outcome. The objective of this study was to determine the prevalence of autoimmunity and of hypothyroidism in the melanoma population as a whole and to determine if t...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200112000-00010
更新日期:2001-12-01 00:00:00
abstract::Treatment of patients with metastatic uveal melanoma is very challenging because the tumor commonly spreads to the liver, surgical resection of metastases is rarely possible, and there is no standard effective systemic therapy. We report the case of a 38-year-old man, who presented with metastatic involvement of the l...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e328344958c
更新日期:2011-04-01 00:00:00
abstract::Melanoma is among the most chemotherapy-resistant malignancies. Numerous new agents have been developed that target specific molecules on cancer cells, including the monoclonal antibody trastuzumab, which targets Her2/neu and has been very beneficial in the treatment of breast cancer. There are conflicting reports in ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/01.cmr.0000130874.33504.2f
更新日期:2004-06-01 00:00:00
abstract::Tumor cell invasion through basement membranes and into stromal tissue are key steps for promoting growth and metastasis. Tumor cells express various extracellular-matrix-degrading enzymes such as matrix metalloproteinases (MMPs) to degrade extracellular matrix components to facilitate tumor migration and invasion. Hi...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3282a660ad
更新日期:2007-08-01 00:00:00
abstract::Datasets from large health maintenance organizations (HMOs), particularly those with established cancer registries that report to the Surveillance, Epidemiology, and End Results program, are potentially excellent resources for studying melanoma epidemiology and outcomes. However, generalizability of the findings beyon...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000087
更新日期:2014-08-01 00:00:00
abstract::Checkpoint inhibitor immunotherapy is a transformative treatment for advanced malignancies, but can be associated with numerous immune-related adverse events (irAEs). The majority of irAEs include those that closely resemble known cutaneous and neurocutaneous autoimmune or autoinflammatory diseases, such as scleroderm...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000642
更新日期:2020-06-01 00:00:00
abstract::We studied the levels of serum copper and zinc as possible diagnostic factors or markers for the early detection of patients with melanoma. Levels were determined in 35 melanoma patients at various clinical stages and in 39 healthy persons. Measurements were performed by atomic absorption spectroscopy using 5100-PC-Pe...
journal_title:Melanoma research
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Ultraviolet-B (UV-B) triggers a cascade of events involving cell cycle control genes leading ultimately to DNA repair or apoptosis. The hypothesis examined here is that the genetic abnormality predisposing to melanoma affects the ability of the cell to respond appropriately to UV-B, so favouring mutagenesis. Epstein-B...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200102000-00001
更新日期:2001-02-01 00:00:00
abstract::Resistance to various antineoplastic agents is common in the clinical management of malignant melanoma. The biological mechanisms conferring these different drug-resistant phenotypes are still unclear. To identify potential factors mediating drug resistance to melanoma cells, the mRNA expression profiles of the parent...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/01.cmr.0000215037.23188.58
更新日期:2006-04-01 00:00:00
abstract::Selective sentinel lymph node (SLN) dissection is widely used in the management of cutaneous melanoma patients without clinical evidence of nodal metastases. A series of 274 consecutive melanoma patients who underwent melanoma primary excision and SLN mapping at our institutions since 1998, and were thereafter followe...
journal_title:Melanoma research
pub_type: 临床试验,杂志文章
doi:10.1097/00008390-200404000-00016
更新日期:2004-04-01 00:00:00
abstract::Dermatologic toxicity is a known reaction of ipilimumab and vemurafenib. Because of the lack of effective treatments and aggressive nature of melanoma, treatments are often discontinued and new treatments are initiated in rapid succession. We report what we believe to be the first case of cumulative dermatologic toxic...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000018
更新日期:2013-12-01 00:00:00
abstract::Glutathione (GSH) is the major non-protein thiol in cells that plays a critical role against damage from electrophilic agents such as alkylating drugs. Selective therapeutic GSH elevation in normal but not in tumour cells has been suggested as a means of protecting host tissues against more intense doses of chemothera...
journal_title:Melanoma research
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro. Up to 50% inhibition of dopachrome formation was observed in the tyrosinase-dopa reaction in the presence of t...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199712000-00006
更新日期:1997-12-01 00:00:00
abstract::Identifying groups of subjects at high risk for the development of melanoma is crucial for the early diagnosis of curable tumours. In the present study, we performed a skin examination in a group of 63 patients followed up after treatment of germ cell tumours (GCTs) who were referred to the dermatologist for multiple ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200104000-00005
更新日期:2001-04-01 00:00:00
abstract::The primary treatment of a melanoma is surgical excision. An excisional biopsy is preferred, and safety margins of 1 cm for tumor thickness up to 2 mm and 2 cm for higher tumor thickness should be applied either at primary excision or in a two-step procedure. When dealing with facial, acral or anogenital melanomas, mi...
journal_title:Melanoma research
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1097/CMR.0b013e3282f0c893
更新日期:2008-02-01 00:00:00
abstract::The correlation between ultraviolet radiation of the skin and melanoma incidence in humans is well established. Interestingly, epidemiologic data suggest also a correlation to an increased BMI pointing to metabolic trigger factors in melanoma pathogenesis. To substantiate this connection, we studied the expression of ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000445
更新日期:2018-08-01 00:00:00
abstract::To study the mechanisms by which insulin regulates proliferation, we have compared wild-type Cloudman melanoma cells, whose growth in inhibited by insulin (insinh) to variant lines that were genetically selected for resistance to insulin (insres). Scatchard analysis of insulin binding to five insres) lines and six ins...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199207000-00006
更新日期:1992-07-01 00:00:00
abstract::The objective of this study is to assess the expression of heat shock protein 105 (HSP105) in melanoma and benign melanocytic lesions. The expression of HSP105 in 62 human melanoma samples--46 primary and 16 metastatic lesions--and 42 melanocytic naevi samples, was assessed by immunohistochemistry. Western blotting wa...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3282fe9a16
更新日期:2008-06-01 00:00:00
abstract::Melanoma is the most lethal skin tumor in large part because of a propensity for early metastasis. Good models of this most clinically relevant feature of melanoma are lacking. Here, we report the development of an in-vivo model of metastasis that relies on orthotopic injection of green fluorescent protein-tagged line...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e328336ee17
更新日期:2010-10-01 00:00:00
abstract::Recently, we reported on the associations of seven single nucleotide polymorphisms (SNPs) in the promoter region of MMP1 gene with susceptibility to cutaneous melanoma (CM). Considering the reported correlation between MMP1 expression and melanoma progression, we hypothesized that these promoter SNPs might affect CM p...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e32834fc46b
更新日期:2012-04-01 00:00:00
abstract::Dissemination of uveal melanomas is almost exclusively haematogenous, making angiogenesis of the tumour a prerequisite for the formation of metastases. Uveal melanomas must employ strategies to evade the immune system in order to escape immune surveillance. We therefore determined the expression of the following angio...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199910000-00003
更新日期:1999-10-01 00:00:00