Abstract：
:Interleukin (IL)-33 is a key cytokine involved in type 2 immunity and allergic airway diseases. Abundantly expressed in lung epithelial cells, IL-33 plays critical roles in both innate and adaptive immune responses in mucosal organs. In innate immunity, IL-33 and group 2 innate lymphoid cells (ILC2s) provide an essential axis for rapid immune responses and tissue homeostasis. In adaptive immunity, IL-33 interacts with dendritic cells, Th2 cells, follicular T cells, and regulatory T cells, where IL-33 influences the development of chronic airway inflammation and tissue remodeling. The clinical findings that both the IL-33 and ILC2 levels are elevated in patients with allergic airway diseases suggest that IL-33 plays an important role in the pathogenesis of these diseases. IL-33 and ILC2 may also serve as biomarkers for disease classification and to monitor the progression of diseases. In this article, we reviewed the current knowledge of the biology of IL-33 and discussed the roles of the IL-33 in regulating airway immune responses and allergic airway diseases.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Drake LY,Kita Hdoi
10.1111/imr.12552subject
Has Abstractpub_date
2017-07-01 00:00:00pages
173-184issue
1eissn
0105-2896issn
1600-065Xjournal_volume
278pub_type
杂志文章,评审abstract：:Mutations of the genes encoding T-cell receptor (TCR)-proximal signaling molecules, such as ZAP-70, can be causative of immunological diseases ranging from T-cell immunodeficiency to T-cell-mediated autoimmune disease. For example, SKG mice, which carry a hypomorphic point mutation of the Zap-70 gene, spontaneously de...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Immunological reviews
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更新日期：1998-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
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pub_type： 杂志文章,评审
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2017-11-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2016-05-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2016-07-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2004-10-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2017-03-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2011-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2002-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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更新日期：2021-01-07 00:00:00
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更新日期：2005-04-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1997-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2007-06-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2001-06-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1984-10-01 00:00:00
abstract：:Activation of immune cells to mediate an immune response is often triggered by potential 'danger' or 'stress' stimuli that the organism receives. Within the mitogen-activated protein kinases (MAPKs) family, the stress-activated protein kinase (SAPK) group was defined as group of kinases that activated by stimuli that ...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2009-03-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1999.tb01359.x
更新日期：1999-12-01 00:00:00
