Neuroendocrine regulation of innate lymphoid cells.

abstract：:Pellinos are a family of E3 ubiquitin ligases discovered for their role in catalyzing K63-linked polyubiquitination of Pelle, an interleukin-1 (IL-1) receptor-associated kinase homolog in the Drosophila Toll pathway. Subsequent studies have revealed the central and non-redundant roles of mammalian Pellino-1, Pellino-2...

journal_title：Immunological reviews

authors： Medvedev AE,Murphy M,Zhou H,Li X

更新日期：2015-07-01 00:00:00

abstract：:The mammalian defense system can respond to a variety of threats, but this capability is not just a simple alarm system for triggering antigen-presenting cells and initiating cellular immunity. Instead, the body is an integrated system in which nearly every cell type can relay the alarm through the production of chemo...

journal_title：Immunological reviews

authors： Lo D,Feng L,Li L,Carson MJ,Crowley M,Pauza M,Nguyen A,Reilly CR

更新日期：1999-06-01 00:00:00

abstract：:Structures of two intact monoclonal antibodies were solved by X-ray diffraction analysis revealing, in both cases, the dispositions of all segments, as well as the structures of the hinge polypeptides. An IgG1, whose antigen is the drug phenobarbital, assumed a completely different conformation when compared with an I...

journal_title：Immunological reviews

authors： Harris LJ,Larson SB,Skaletsky E,McPherson A

更新日期：1998-06-01 00:00:00

abstract：:The scale and scope of the global epidemic, coupled to challenges with traditional vaccine development approaches, point toward a need for novel methodologies for HIV vaccine research. While the development of vaccines able to induce broadly neutralizing antibodies remains the ultimate goal, to date, vaccines continue...

journal_title：Immunological reviews

authors： Ackerman ME,Barouch DH,Alter G

更新日期：2017-01-01 00:00:00

abstract：:Inflammation underpins the development of atherosclerosis. Initiation and progression of vascular inflammation involves a complex cellular network, with macrophages as major contributors. Activated macrophages produce proinflammatory mediators, bridge innate and adaptive immunity, regulate lipid retention, and partici...

journal_title：Immunological reviews

authors： Yan ZQ,Hansson GK

更新日期：2007-10-01 00:00:00

abstract：:Genes encoding several serum complement components and the gene(s) for steroid 21-hydroxylase (21-OH) have been located in the class III region of the major histocompatibility complex (MHC). All these genes are highly polymorphic in man, and these polymorphisms have been used to draw conclusions about the structure an...

journal_title：Immunological reviews

authors： White PC,New MI,Dupont B

更新日期：1985-10-01 00:00:00

abstract：:Rabbits have helped elucidate one of the major immunologic puzzles, namely the genetic control of antibody diversity. The primary IgH antibody repertoire in rabbits is dominated by B cells that use the same germline VH-gene segment in VDJ gene rearrangements. The VDJ genes of essentially all B lymphocytes undergo soma...

journal_title：Immunological reviews

authors： Knight KL,Barrington RA

更新日期：1998-04-01 00:00:00

abstract：:T-cell development is a highly coordinated process that depends on interactions between thymocytes, thymic epithelium, and bone marrow (BM)-derived dendritic cells (DCs). Before entering the peripheral T-cell pool, thymocytes are subject to negative selection, a process that eliminates (or deletes) T cells with high a...

journal_title：Immunological reviews

authors： Gallegos AM,Bevan MJ

更新日期：2006-02-01 00:00:00

abstract：SUMMARY:B7-H3 and B7-H4 belong to a new class of immune regulatory molecules, which primarily execute their functions in peripheral tissues to fine tune immune responses in target organs. In normal circumstances, while the mRNA for both molecules is broadly distributed, tight control at the post-transcriptional level i...

journal_title：Immunological reviews

authors： Yi KH,Chen L

更新日期：2009-05-01 00:00:00

abstract：:NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the kille...

journal_title：Immunological reviews

authors： Lanier LL,Corliss B,Phillips JH

更新日期：1997-02-01 00:00:00

abstract：:The immune system is organized as a number of distinct lymphoid organs interconnected by recirculating lymphocytes. These organs, such as lymph nodes, spleen, and gut-associated Peyer's patches, are compartmentalized, providing separate niches for T and B cells. In addition, regional compartmentalization of lymphoid o...

journal_title：Immunological reviews

authors： Kraal G,Samsom JN,Mebius RE

更新日期：2006-10-01 00:00:00

abstract：:Mutations of the genes encoding T-cell receptor (TCR)-proximal signaling molecules, such as ZAP-70, can be causative of immunological diseases ranging from T-cell immunodeficiency to T-cell-mediated autoimmune disease. For example, SKG mice, which carry a hypomorphic point mutation of the Zap-70 gene, spontaneously de...

journal_title：Immunological reviews

authors： Takeuchi Y,Hirota K,Sakaguchi S

更新日期：2020-03-01 00:00:00

abstract：:Chronic inflammation in the tumor microenvironment and evasion of the antitumor effector immune response are two of the emerging hallmarks required for oncogenesis and cancer progression. The innate immune system not only plays a critical role in perpetuating these tumor-promoting hallmarks but also in developing anti...

journal_title：Immunological reviews

authors： Berraondo P,Minute L,Ajona D,Corrales L,Melero I,Pio R

更新日期：2016-11-01 00:00:00

abstract：:Directed cellular migrations underlie immune system organization. Chemokines and their receptors (along with surface-adhesion molecules) are central to these migrations, targeting developing and mature leukocytes to tissues and microenvironments suitable for their differentiation and function. The chemokine CXCL12 and...

journal_title：Immunological reviews

authors： Campbell DJ,Kim CH,Butcher EC

更新日期：2003-10-01 00:00:00

abstract：:Solid organ transplantation is a vital therapy for end stage diseases. Decades of research have established that components of the adaptive immune system are critical for transplant rejection, but the role of the innate immune system in organ transplantation is just emerging. Accumulating evidence indicates that the i...

journal_title：Immunological reviews

authors： Mori DN,Kreisel D,Fullerton JN,Gilroy DW,Goldstein DR

更新日期：2014-03-01 00:00:00

abstract：:Over the past 20 years, major progress has been made in our understanding of natural killer (NK) cells. It has become clear that NK cells are regulated by a number of receptors with opposite functions that finely tune potent effector functions such as cytolytic activity and release of cytokines that play a major role ...

journal_title：Immunological reviews

authors： Moretta A,Locatelli F,Moretta L

更新日期：2008-08-01 00:00:00

abstract：:The immunoreceptor tyrosine-based activation motif (ITAM) is a highly conserved region in the cytoplasmic domain of signaling chains and receptors and is a critical mediator of intracellular signals. ITAM-mediated signals depend on the Syk or zeta-associated protein of 70 kDa tyrosine kinases, and ITAM signaling is re...

journal_title：Immunological reviews

authors： Humphrey MB,Lanier LL,Nakamura MC

更新日期：2005-12-01 00:00:00

abstract：:T-cell development primarily occurs in the thymus and involves in the interactions of many important transcription factors. Until recently, no single transcription factor has been identified to be essential for T-cell lineage commitment or maintenance of T-cell identity. Recent studies have now identified the zinc fin...

journal_title：Immunological reviews

authors： Liu P,Li P,Burke S

更新日期：2010-11-01 00:00:00

abstract：:Since the discovery that the recombination-activating gene (RAG) proteins were capable of transposition in vitro, investigators have been trying to uncover instances of transposition in vivo and understand how this transposase has been harnessed to do useful work while being inhibited from causing deleterious chromoso...

journal_title：Immunological reviews

authors： Brandt VL,Roth DB

更新日期：2004-08-01 00:00:00

abstract：:Peptide/protein display libraries are powerful tools for identifying and manipulating receptor/ligand pairs. While the large size of bacterial phage display libraries has made them the platform of choice in many applications, often considerable engineering has been required to achieve display of properly folded and ac...

journal_title：Immunological reviews

authors： Crawford F,Jordan KR,Stadinski B,Wang Y,Huseby E,Marrack P,Slansky JE,Kappler JW

更新日期：2006-04-01 00:00:00

abstract：:Idiotypic networks, after being a dominating paradigm for more than a decade, have fallen out of fashion in parallel with the rapid success of molecular immunobiology. Today signs of a possible renaissance in idiotypic network studies are visible. For system biologists and also for physicists, the network idea remains...

journal_title：Immunological reviews

authors： Behn U

更新日期：2007-04-01 00:00:00

abstract：:T cells are key players of the mammalian adaptive immune system. They experience different mechanical microenvironments during their life cycle, from the thymus, secondary lymph organs, and peripheral tissues that are free of externally applied force, but display variable substrate rigidities to the blood and lymphati...

journal_title：Immunological reviews

authors： Chen W,Zhu C

更新日期：2013-11-01 00:00:00

abstract：:There are two distinct pathways by which T cells may recognize MHC alloantigens. The direct pathway involves T-cell recognition of intact MHC molecules expressed by donor antigen-presenting cells (APCs). The second, or indirect, pathway describes T-cell recognition of peptides derived from the processing and presentat...

journal_title：Immunological reviews

authors： Suciu-Foca N,Harris PE,Cortesini R

更新日期：1998-08-01 00:00:00

abstract：:Francisella tularensis in an intracellular bacterial pathogen that causes a potentially lethal disease called tularemia. Studies performed nearly 100 years ago revealed that neutrophil accumulation in infected tissues correlates directly with the extent of necrotic damage during F. tularensis infection. However, the d...

journal_title：Immunological reviews

authors： Kinkead LC,Allen LA

更新日期：2016-09-01 00:00:00

abstract：:After more than a decade of intensive research, the precise role of human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL) in determining the course of the infection remains open to argument. It is established that HIV-specific CTL appear early in the infection and are temporally associated with the...

journal_title：Immunological reviews

authors： Goulder P,Price D,Nowak M,Rowland-Jones S,Phillips R,McMichael A

更新日期：1997-10-01 00:00:00

abstract：:Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non-human primates, account for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T-cell subpopulation capable of recognizing the microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by selected pathoge...

journal_title：Immunological reviews

authors： Shen L,Huang D,Qaqish A,Frencher J,Yang R,Shen H,Chen ZW

更新日期：2020-11-01 00:00:00

abstract：:DOCK8 immunodeficiency syndrome (DIDS) is a progressive combined immunodeficiency that can be distinguished from other combined immunodeficiencies or hyperimmunoglobulinemia E syndromes in featuring (a) profound susceptibility to virus infections of the skin, with associated skin cancers, and (b) severe food allergies...

journal_title：Immunological reviews

authors： Su HC,Jing H,Angelus P,Freeman AF

更新日期：2019-01-01 00:00:00

abstract：:More than 20 years ago, immunologists discovered that resistance and susceptibility to experimental infection with the intracellular protozoan Leishmania major was associated with the development of T-helper 1 (Th1)- and Th2-dominated immune responses, respectively. This infectious disease model was later used to iden...

journal_title：Immunological reviews

authors： Mougneau E,Bihl F,Glaichenhaus N

更新日期：2011-03-01 00:00:00

abstract：:Recognition of peptide presented by the major histocompatibility complex (pMHC) molecule by the T-cell receptor (TCR) determines T-cell selection, development, differentiation, fate, and function. Despite intensive studies on the structures, thermodynamic properties, kinetic rates, and affinities of TCR-pMHC interacti...

journal_title：Immunological reviews

authors： Zhu C,Jiang N,Huang J,Zarnitsyna VI,Evavold BD

更新日期：2013-01-01 00:00:00

abstract：:Inflammasomes are the central signaling hubs of the inflammatory response. They process cytosolic evidence of infection, cell damage, or metabolic disturbances, and elicit a pro-inflammatory response mediated by members of the interleukin-1 family of cytokines and pyroptotoic cell death. On the molecular level, this i...

journal_title：Immunological reviews

authors： Franklin BS,Latz E,Schmidt FI

更新日期：2018-01-01 00:00:00