Abstract：
:Polymorphonuclear neutrophils (PMNs) are innate immune system cells that play an essential role in eradicating invading pathogens. PMN migration to sites of infection/inflammation requires exiting the microcirculation and subsequent crossing of epithelial barriers in mucosa-lined organs such as the lungs and intestines. Although these processes usually occur without significant damage to surrounding host tissues, dysregulated/excessive PMN transmigration and resultant bystander-tissue damage are characteristic of numerous mucosal inflammatory disorders. Mechanisms controlling PMN extravasation have been well characterized, but the molecular details regarding regulation of PMN migration across mucosal epithelia are poorly understood. Given that PMN migration across mucosal epithelia is strongly correlated with disease symptoms in many inflammatory mucosal disorders, enhanced understanding of the mechanisms regulating PMN transepithelial migration should provide insights into clinically relevant tissue-targeted therapies aimed at ameliorating PMN-mediated bystander-tissue damage. This review will highlight current understanding of the molecular interactions between PMNs and mucosal epithelia and the associated functional consequences.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Brazil JC,Parkos CAdoi
10.1111/imr.12446subject
Has Abstractpub_date
2016-09-01 00:00:00pages
94-111issue
1eissn
0105-2896issn
1600-065Xjournal_volume
273pub_type
杂志文章,评审abstract：:Natural killer (NK) cells respond rapidly to transformed, stressed, or virally infected cells and provide a first-line immune defense against pathogen invasion and cancer. Thought to involve short-lived effector cells that are armed for battle, NK cells were not previously known to contribute in recall responses to pa...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2014-05-01 00:00:00
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更新日期：2018-11-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2012-09-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2005-12-01 00:00:00
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更新日期：2006-02-01 00:00:00
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更新日期：2019-11-01 00:00:00
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更新日期：2001-04-01 00:00:00
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journal_title：Immunological reviews
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更新日期：1998-12-01 00:00:00
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更新日期：2000-10-01 00:00:00
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journal_title：Immunological reviews
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更新日期：1985-07-01 00:00:00
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更新日期：2007-06-01 00:00:00
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更新日期：2010-01-01 00:00:00
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journal_title：Immunological reviews
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更新日期：1999-12-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1992-08-01 00:00:00
