Abstract:
:Inflammasomes are multiprotein complexes that control the maturation and production of interleukin-1 family members and play crucial roles in host defense against pathogens. However, dysregulated activation of inflammasomes is associated with intense inflammation, leading to the development of inflammatory diseases. Therefore, inflammasomes must be activated at a proper strength to protect against infection and avoid tissue damage. Recent studies have highlighted the cross-talk between inflammasome activation and autophagy, the cellular machinery associated with the degradation of intracellular components and maintenance of cellular homeostasis. Notably, deficiencies in autophagy-related proteins induce the aberrant activation of inflammasomes, causing severe tissue damage. In contrast, autophagy inducers ameliorate symptoms of inflammasome-related diseases. In this review, we discuss recent advances in the involvement of autophagy in regulating inflammasomes activation and in the development of inflammatory diseases.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Takahama M,Akira S,Saitoh Tdoi
10.1111/imr.12613subject
Has Abstractpub_date
2018-01-01 00:00:00pages
62-73issue
1eissn
0105-2896issn
1600-065Xjournal_volume
281pub_type
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journal_title:Immunological reviews
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journal_title:Immunological reviews
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journal_title:Immunological reviews
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journal_title:Immunological reviews
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journal_title:Immunological reviews
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更新日期:2000-06-01 00:00:00
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journal_title:Immunological reviews
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