Abstract：
:Obesity is an established risk factor for many cancers and has recently been found to alter the efficacy of T cell-based immunotherapies. Currently, however, the effects of obesity on immunometabolism remain unclear. Understanding these associations is critical, given the fact that T cell metabolism is tightly linked to effector function. Thus, any obesity-associated changes in T cell bioenergetics are likely to drive functional changes at the cellular level, alter the metabolome and cytokine/chemokine milieu, and impact cancer immunotherapy outcomes. Here, we provide a brief overview of T cell metabolism in the presence and absence of solid tumor growth and summarize current literature regarding obesity-associated changes in T cell function and bioenergetics. We also discuss recent findings related to the impact of host obesity on cancer immunotherapy outcomes and present potential mechanisms by which T cell metabolism may influence therapeutic efficacy. Finally, we describe promising pharmaceutical therapies that are being investigated for their ability to improve CD8 T cell metabolism and enhance cancer immunotherapy outcomes in patients, regardless of their obesity status.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Turbitt WJ,Buchta Rosean C,Weber KS,Norian LAdoi
10.1111/imr.12849subject
Has Abstractpub_date
2020-05-01 00:00:00pages
203-219issue
1eissn
0105-2896issn
1600-065Xjournal_volume
295pub_type
杂志文章,评审abstract：:Idiotypic networks, after being a dominating paradigm for more than a decade, have fallen out of fashion in parallel with the rapid success of molecular immunobiology. Today signs of a possible renaissance in idiotypic network studies are visible. For system biologists and also for physicists, the network idea remains...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2006.00496.x
更新日期：2007-04-01 00:00:00
abstract：:Superantigens (SAGs) are a class of disease-causing and immunostimulatory proteins of bacterial or viral origin that activate T cells by binding to the V beta domain of the T-cell antigen receptor (TCR). The three-dimensional structure of the complex between a TCR beta chain (mouse V beta 8.2-J beta 2.1-C beta 1) and ...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1998.tb01196.x
更新日期：1998-06-01 00:00:00
abstract：:X-linked lymphoproliferative disease (XLP) is an inherited immune defect caused by mutations in the Src homology 2 domain-containing gene 1A, which encodes the adapter protein, signaling lymphocytic activation molecule (SLAM)-associated protein (SAP). SAP is expressed in T cells, natural killer (NK) cells, and NKT cel...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2005.00230.x
更新日期：2005-02-01 00:00:00
abstract：:Mast cells (MCs) are major effector cells of immunoglobulin E (IgE)-mediated allergic inflammation. However, it has become increasingly clear that they also play important roles in diverse physiological and pathological processes. Recent advances have focused on the importance of MCs in both innate and adaptive immune...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2005.00279.x
更新日期：2005-08-01 00:00:00
abstract：:The cellular and molecular mechanisms underlying the formation of distinct central, effector, and exhausted CD8+ T-cell memory subsets were first described in the setting of acute and chronic viral diseases. The role of these T-cell memory subsets are now being illuminated as relevant to the tumor-bearing state. The g...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2006.00391.x
更新日期：2006-06-01 00:00:00
abstract：:Activation of immune cells to mediate an immune response is often triggered by potential 'danger' or 'stress' stimuli that the organism receives. Within the mitogen-activated protein kinases (MAPKs) family, the stress-activated protein kinase (SAPK) group was defined as group of kinases that activated by stimuli that ...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2008.00744.x
更新日期：2009-03-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12537
更新日期：2017-05-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2005.00247.x
更新日期：2005-04-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2005.00310.x
更新日期：2005-10-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12580
更新日期：2017-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2009.00768.x
更新日期：2009-05-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12707
更新日期：2018-11-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1992.tb00834.x
更新日期：1992-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1995.tb00075.x
更新日期：1995-06-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12582
更新日期：2017-11-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12146
更新日期：2014-03-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1990.tb00803.x
更新日期：1990-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2005.00227.x
更新日期：2005-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1995.tb00087.x
更新日期：1995-10-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2007.00579.x
更新日期：2007-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2006-12-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2020-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2009.00817.x
更新日期：2009-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1999.tb01337.x
更新日期：1999-08-01 00:00:00
abstract：:Regulatory T cells (Tregs) and the PD-1: PD-ligand (PD-L) pathway are both critical to terminating immune responses. Elimination of either can result in the breakdown of tolerance and the development of autoimmunity. The PD-1: PD-L pathway can thwart self-reactive T cells and protect against autoimmunity in many ways....
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2010.00923.x
更新日期：2010-07-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12710
更新日期：2018-11-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1997.tb00972.x
更新日期：1997-06-01 00:00:00
abstract：:Hepatitis B virus (HBV) is a major human pathogen that causes chronic infection and life-threatening liver diseases in millions of individuals. While pathological and epidemiological consequences of clinically evident HBV infections are well recognized, there is no similar knowledge on an asymptomatic, silently progre...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1034/j.1600-0528.2002.017406.x
更新日期：2000-04-01 00:00:00
abstract：:Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non-human primates, account for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T-cell subpopulation capable of recognizing the microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by selected pathoge...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12927
更新日期：2020-11-01 00:00:00
