Abstract：
SUMMARY:B7-H3 and B7-H4 belong to a new class of immune regulatory molecules, which primarily execute their functions in peripheral tissues to fine tune immune responses in target organs. In normal circumstances, while the mRNA for both molecules is broadly distributed, tight control at the post-transcriptional level is imposed. Under a pathogenic environment, such as inflammation and cancer, the control is often aberrant. Upon engaging their receptors, these molecules regulate the immune response in positive or negative ways depending on the expression and type of cells bearing the receptors. Thus, manipulation of the expression of these molecules and/or their receptors may represent a realistic opportunity to fine tune immune responses and to design new immunotherapeutic approaches.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Yi KH,Chen Ldoi
10.1111/j.1600-065X.2009.00768.xsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
145-51issue
1eissn
0105-2896issn
1600-065Xpii
IMR768journal_volume
229pub_type
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journal_title：Immunological reviews
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pub_type： 杂志文章,评审
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更新日期：2017-11-01 00:00:00
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更新日期：2015-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2008-08-01 00:00:00
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更新日期：2017-05-01 00:00:00
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更新日期：2005-10-01 00:00:00
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更新日期：2018-11-01 00:00:00
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pub_type： 杂志文章,评审
doi：
更新日期：2000-06-01 00:00:00
