Abstract：
:Immune responses to gastrointestinal nematodes have been studied extensively for over 80 years and intensively investigated over the last 30-40 years. The use of laboratory models has led to the discovery of new mechanisms of protective immunity and made major contributions to our fundamental understanding of both innate and adaptive responses. In addition to host protection, it is clear that immunoregulatory processes are common in infected individuals and resistance often operates alongside modulation of immunity. This review aims to discuss the recent discoveries in both host protection and immunoregulation against gastrointestinal nematodes, placing the data in context of the specific life cycles imposed by the different parasites studied and the future challenges of considering the mucosal/immune axis to encompass host, parasite, and microbiome in its widest sense.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Grencis RK,Humphreys NE,Bancroft AJdoi
10.1111/imr.12188subject
Has Abstractpub_date
2014-07-01 00:00:00pages
183-205issue
1eissn
0105-2896issn
1600-065Xjournal_volume
260pub_type
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