Abstract:
:Human immunodeficiency virus-1 (HIV-1) envelope protein (Env) and influenza hemagglutinin (HA) are the surface glycoproteins responsible for viral entry into host cells, the first step in the virus life cycle necessary to initiate infection. These glycoproteins exhibit a high degree of sequence variability and glycosylation, which are used as strategies to escape host immune responses. Nonetheless, antibodies with broadly neutralizing activity against these viruses have been isolated that have managed to overcome these barriers. Here, we review recent advances in the structural characterization of these antibodies with their viral antigens that defines a few sites of vulnerability on these viral spikes. These broadly neutralizing antibodies tend to focus their recognition on the sites of similar function between the two viruses: the receptor-binding site and membrane fusion machinery. However, some sites of recognition are unique to the virus neutralized, such as the dense shield of oligomannose carbohydrates on HIV-1 Env. These observations are discussed in the context of structure-based design strategies to aid in vaccine design or development of antivirals.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Julien JP,Lee PS,Wilson IAdoi
10.1111/imr.12005subject
Has Abstractpub_date
2012-11-01 00:00:00pages
180-98issue
1eissn
0105-2896issn
1600-065Xjournal_volume
250pub_type
杂志文章,评审abstract::The immune system is organized as a number of distinct lymphoid organs interconnected by recirculating lymphocytes. These organs, such as lymph nodes, spleen, and gut-associated Peyer's patches, are compartmentalized, providing separate niches for T and B cells. In addition, regional compartmentalization of lymphoid o...
journal_title:Immunological reviews
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journal_title:Immunological reviews
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journal_title:Immunological reviews
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更新日期:2016-01-01 00:00:00
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journal_title:Immunological reviews
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journal_title:Immunological reviews
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abstract::Vaccines or early childhood exposure to infection mediate immunity, that is, improved resistance against disease and death caused by a second infection with the same agent. This has been explained by and equaled to immunological memory, that is, an "altered immune system behavior" that is maintained in a presumably an...
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journal_title:Immunological reviews
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更新日期:2009-07-01 00:00:00
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journal_title:Immunological reviews
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更新日期:2004-08-01 00:00:00
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更新日期:1999-02-01 00:00:00
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更新日期:2007-04-01 00:00:00
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更新日期:2014-09-01 00:00:00
abstract::The development of vaccines is presently receiving major attention in malaria research. As it is not possible to base malaria vaccines on the use of killed or attenuated organisms, the vaccines which are being developed are subunit vaccines in which the immunogens consist of defined parasite antigens or antigenic frag...
journal_title:Immunological reviews
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更新日期:1989-12-01 00:00:00
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-08-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
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更新日期:1990-10-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
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更新日期:1998-04-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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更新日期:2004-02-01 00:00:00
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更新日期:2015-07-01 00:00:00
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更新日期:2020-01-01 00:00:00
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更新日期:2014-11-01 00:00:00
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更新日期:2018-11-01 00:00:00
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更新日期:2010-01-01 00:00:00
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abstract::Newfound relatives of the classical Fc receptors (FcR) have been provisionally named the Fc receptor homologs (FcRH). The recent identification of eight human and six mouse FcRH genes substantially increases the size and functional potential of the FcR family. The extended family of FcR and FcRH genes spans approximat...
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更新日期:2002-12-01 00:00:00
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更新日期:2011-09-01 00:00:00
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journal_title:Immunological reviews
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更新日期:2005-06-01 00:00:00
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journal_title:Immunological reviews
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更新日期:1997-06-01 00:00:00
abstract::αβ T cells are an integral part of protective immunity against pathogens. After precursor cells arise in the adult bone marrow or fetal liver, they migrate to the thymus where they rearrange their T-cell receptor genes (TCR) and undergo selection on the basis of their interactions with ligands expressed by thymic stro...
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更新日期:2013-09-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12603
更新日期:2017-11-01 00:00:00