Abstract：
:Nutritional status has been indicated as a contributing factor to age-related dysregulation of the immune response. Vitamin E, a lipid-soluble antioxidant vitamin, is important for normal function of the immune cells. The elderly are at a greater risk for vitamin E intake that is lower than recommended levels. Vitamin E supplementation above currently recommended levels has been shown to improve immune functions in the aged including delayed-type hypersensitivity skin response and antibody production in response to vaccination, which was shown to be mediated through increased production of interleukin (IL)-2, leading to enhanced proliferation of T cells, and through reduced production of prostaglandin E(2), a T-cell suppressive factor, as a result of a decreased peroxynitrite formation. Vitamin E increased both cell-dividing and IL-producing capacities of naive T cells, but not memory T cells. The vitamin E-induced enhancement of immune functions in the aged was associated with significant improvement in resistance to influenza infection in aged mice and a reduced risk of acquiring upper respiratory infections in nursing home residents. Further studies are needed to determine the signaling mechanisms involved in the upregulation of naive T-cell function by vitamin E as well as the specific mechanisms involved in reduction of risk for upper respiratory infections.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Meydani SN,Han SN,Wu Ddoi
10.1111/j.0105-2896.2005.00274.xkeywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
269-84eissn
0105-2896issn
1600-065Xpii
IMR274journal_volume
205pub_type
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journal_title：Immunological reviews
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更新日期：2000-06-01 00:00:00
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更新日期：2007-10-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2003-12-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2009.00816.x
更新日期：2009-09-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2013-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1990.tb00804.x
更新日期：1990-08-01 00:00:00
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更新日期：2000-10-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2016-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2002-10-01 00:00:00
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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更新日期：2016-09-01 00:00:00
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journal_title：Immunological reviews
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doi：10.1111/j.1600-065X.2007.00513.x
更新日期：2007-06-01 00:00:00
abstract：:On the basis of cell surface markers, mature T cells are considered to have either a naïve or a memory phenotype. These cells exhibit distinct types of kinetic behaviour in vivo. While naïve-phenotype cells persist long term in a non-dividing state, memory-phenotype T cells include cycling cells and exhibit a more rap...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1999.tb01327.x
更新日期：1999-08-01 00:00:00
abstract：SUMMARY:This volume covers many topics in the field of T-cell costimulation. The need for such a volume is testament to the growth of the field. From its beginning as a concept in the 1980s, we have now progressed to the point where many molecules now have functionally defined roles in T-cell costimulation. In addition...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2009.00780.x
更新日期：2009-05-01 00:00:00
abstract：:CD69 has been known as an early activation marker of lymphocytes; whereas, recent studies demonstrate that CD69 also has critical functions in immune responses. Early studies using human samples revealed the involvement of CD69 in various inflammatory diseases including asthma. Moreover, murine disease models using Cd...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12559
更新日期：2017-07-01 00:00:00
abstract：:The number of possible T cell activation outcomes resulting from T cell receptor (TCR) engagement suggests that the TCR is able to differentially activate a myriad of signaling pathways depending on the nature of the stimulus. The complex structural organization of the TCR itself could underlie this diversity of respo...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1034/j.1600-065x.2003.00017.x
更新日期：2003-02-01 00:00:00
