Abstract：
:Newfound relatives of the classical Fc receptors (FcR) have been provisionally named the Fc receptor homologs (FcRH). The recent identification of eight human and six mouse FcRH genes substantially increases the size and functional potential of the FcR family. The extended family of FcR and FcRH genes spans approximately 15 Mb of the human chromosome 1q21-23 region, whereas in mice this family is split between chromosomes 1 and 3. The FcRH genes encode molecules with variable combinations of five subtypes of immunoglobulin (Ig) domains. The presence of a conserved sequence motif in one Ig domain subtype implies Ig Fc binding capability for many FcRH family members that are preferentially expressed by B lineage cells. In addition, most FcRH family members have consensus tyrosine-based activating and inhibitory motifs in their cytoplasmic domains, while the others lack features typical of transmembrane receptors. The FcRH family members, like the classical FcRs, come in multiple isoforms and allelic variations. The unique individual and polymorphic properties of the FcR/FcRH members indicate a remarkably diverse Fc receptor gene family with immunoregulatory function.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Davis RS,Dennis G Jr,Odom MR,Gibson AW,Kimberly RP,Burrows PD,Cooper MDdoi
10.1034/j.1600-065x.2002.19009.xkeywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
123-36eissn
0105-2896issn
1600-065Xpii
imr19009journal_volume
190pub_type
杂志文章,评审abstract：:Vaccines or early childhood exposure to infection mediate immunity, that is, improved resistance against disease and death caused by a second infection with the same agent. This has been explained by and equaled to immunological memory, that is, an "altered immune system behavior" that is maintained in a presumably an...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
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journal_title：Immunological reviews
pub_type： 杂志文章,收录出版,评审
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更新日期：2001-10-01 00:00:00
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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更新日期：2014-11-01 00:00:00
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journal_title：Immunological reviews
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1991-12-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2001-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1996-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2003-12-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1997-06-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2010.00900.x
更新日期：2010-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2009-07-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1989.tb00545.x
更新日期：1989-10-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1999.tb01381.x
更新日期：1999-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1034/j.1600-065x.2001.1820111.x
更新日期：2001-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1999-12-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2004-10-01 00:00:00
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更新日期：2000-04-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1999-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1997-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2020-07-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2007-10-01 00:00:00
abstract：:Human immunodeficiency virus infection is still one of the most important causes of morbidity and mortality in the world, with a disproportionate human and economic burden especially in poorer countries. Despite many years of intense research, an aspect that still is not well understood is what (immune) mechanisms con...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12691
更新日期：2018-09-01 00:00:00
abstract：:One of the biggest barriers to achieving allograft tolerance is the presence of immunological memory within the recipient, which confers a faster, more robust immune response that is in most cases more resistant to pharmacologic immunosuppression. This review will identify the mechanisms by which alloreactive T cells ...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12824
更新日期：2019-11-01 00:00:00
abstract：:The common cytokine receptor gamma chain (gamma c) plays a critical role in lymphoid development through its participation in the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. Absence of gamma c results in abnormal lymphopoiesis and immunodeficiency, as evidence by X-linked severe combined immunodeficiency (SCIDX1)...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1995.tb00091.x
更新日期：1995-12-01 00:00:00
abstract：:NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the kille...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1997.tb00947.x
更新日期：1997-02-01 00:00:00
