Abstract:
:One of the biggest barriers to achieving allograft tolerance is the presence of immunological memory within the recipient, which confers a faster, more robust immune response that is in most cases more resistant to pharmacologic immunosuppression. This review will identify the mechanisms by which alloreactive T cells arise within hosts prior to transplantation, and explore the properties of immunological memory that contribute to allograft rejection. In doing so we will also illuminate how targeting pathways that induce memory T cell exhaustion can promote allograft tolerance. Recent studies demonstrating the impact of the allograft microenvironment on memory cell survival and activation, as well as new therapeutic strategies that are being explored to mitigate memory driven allograft rejection, will also be reviewed.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Hartigan CR,Sun H,Ford MLdoi
10.1111/imr.12824subject
Has Abstractpub_date
2019-11-01 00:00:00pages
225-242issue
1eissn
0105-2896issn
1600-065Xjournal_volume
292pub_type
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journal_title:Immunological reviews
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