Abstract:
:Leishmania major infections induce the development of a CD4(+) T-helper 1 (Th1) response that not only controls the primary infection but also results in life-long immunity to reinfection. How that immunity is maintained is unknown, although because of the existence of infection-induced immunity, there has been an assumption that the development of a vaccine against leishmaniasis would be relatively easy. This has turned out not to be the case. One problem has been the finding that a large part of the immunity induced by a primary infection depends upon the presence of persistent parasites. Nevertheless, there are ample situations where immunologic memory persists without the continued presence of antigen, providing the prospect that a non-live vaccine for leishmaniasis can be developed. To do so will require an understanding of the events involved in the development of an effective protective T-cell response and, more importantly, an understanding of how to maintain that response. Here, we review work from our laboratory, describing how Th1 cells develop in L. major-infected mice, the nature of the memory T cells that provide protection to reinfection, and how that information may be utilized in the development of vaccines.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Scott P,Artis D,Uzonna J,Zaph Cdoi
10.1111/j.0105-2896.2004.00198.xkeywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
318-38eissn
0105-2896issn
1600-065Xpii
IMR198journal_volume
201pub_type
杂志文章,评审abstract::Studies over the last decade uncovered overlapping niches for hematopoietic stem cells (HSCs), multipotent progenitor cells, common lymphoid progenitors, and early B cell progenitors. HSC and lymphoid niches are predominantly composed by mesenchymal progenitor cells (MPCs) and by a small subset of endothelial cells. N...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12749
更新日期:2019-05-01 00:00:00
abstract::The major histocompatibility complex (MHC) plays a central role in controlling immune responsiveness, susceptibility to certain diseases and histo-incompatibility. A physical map of the complete rat MHC, the RTI complex, is presented based on a PAC clonal contig (RT1n haplotype). Expression profiling of various tissue...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2001.1840108.x
更新日期:2001-12-01 00:00:00
abstract::The precise mechanisms that govern memory T-cell lineage commitment during an immune response continue to be the subject of intense scrutiny. The existence of memory T-cell subsets defined by location, function, and phenotype adds an additional layer of complexity to the overall memory T-cell population. In this revie...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2006.00393.x
更新日期:2006-06-01 00:00:00
abstract::Studies of the regulation of gene expression historically focused on transcription. However, during stress and apoptosis, profound gene expression changes occur more rapidly and globally than is possible by regulating transcription. Posttranscriptional changes in mRNA processing and translation in response to diverse ...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12052
更新日期:2013-05-01 00:00:00
abstract::Natural killer (NK) cells of inbred mice reject allogeneic bone-marrow cells, and NK cells of F1 hybrid mice can reject parental bone-marrow cells (hybrid resistance). In some cases these patterns of rejection can be mimicked in vitro by utilizing IL-2 cultured NK effector cells and allogeneic or parental T-lymphoblas...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1997.tb00937.x
更新日期:1997-02-01 00:00:00
abstract::The sequence analysis of Ig variable region genes transcribed within different B-cell subpopulations from human tonsil led us to identify a rare DNA sequence modification event consisting of bp insertions and/or deletions (I/D). Although these events were previously reported, they had never been formally associated wi...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1998.tb01437.x
更新日期:1998-04-01 00:00:00
abstract::Therapeutic efficacy of depleting B cells or blocking T-cell costimulation in rheumatoid arthritis (RA) has confirmed the critical pathogenic role of adaptive immune responses. Yet, RA preferentially affects elderly individuals, in whom adaptive immunity to exogenous antigens begins to fail. Here, we propose that sene...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2005.00245.x
更新日期:2005-04-01 00:00:00
abstract::This review discusses situations when the magnitude and function of immune responses to virus infection are influenced by regulatory T cells (Tregs). The focus is on CD4+ CD25+ forkhead box protein 3+ natural Tregs (nTregs). The immune response may be limited in magnitude and efficacy when animals with normal nTreg fu...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2006.00412.x
更新日期:2006-08-01 00:00:00
abstract::Human T cell hybridomas were generated by several techniques and the supernatants generated were screened for activity on human B cells. Three general activities were noted; B cell proliferation factor ( BCPF ), B cell differentiation factor (BCDF), and an IgA isotype-specific helper factor. BCPF acts on B cells to in...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1984.tb00479.x
更新日期:1984-04-01 00:00:00
abstract::Pellinos are a family of E3 ubiquitin ligases discovered for their role in catalyzing K63-linked polyubiquitination of Pelle, an interleukin-1 (IL-1) receptor-associated kinase homolog in the Drosophila Toll pathway. Subsequent studies have revealed the central and non-redundant roles of mammalian Pellino-1, Pellino-2...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12298
更新日期:2015-07-01 00:00:00
abstract::Interest in DNA immunization of animals continues, despite the fact that immune responses induced by DNA vaccines are generally lower than those elicited by conventional vaccines. In attempts to enhance the immune response to DNA vaccines, individuals have tried a variety of immune modulators, cytokines, and costimula...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2004.00140.x
更新日期:2004-06-01 00:00:00
abstract::Multiple myeloma (MM) is a tumor of long-lived bone marrow plasma cells (PCs). Nearly 40% of MM tumors have immunoglobulin H (IgH) translocations involving four recurrent chromosomal loci (oncogenes): 11q13 (cyclin D1), 6p21 (cyclin D3), 4p16 (MMSET and FGFR3), and 16q23 (c-maf). Other MM tumors have Ig translocations...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2003.00052.x
更新日期:2003-08-01 00:00:00
abstract::Understanding how the integrins on leukocytes operate is important because these receptors control the activity of leukocytes in all phases of their lives. Thus integrins control leukocyte development and maturation in bone marrow, the circulation of naive cells in secondary lymphoid tissue, e.g. the lymph nodes, and ...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2002.18614.x
更新日期:2002-08-01 00:00:00
abstract::The immune system is organized as a number of distinct lymphoid organs interconnected by recirculating lymphocytes. These organs, such as lymph nodes, spleen, and gut-associated Peyer's patches, are compartmentalized, providing separate niches for T and B cells. In addition, regional compartmentalization of lymphoid o...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2006.00429.x
更新日期:2006-10-01 00:00:00
abstract:SUMMARY:Interleukin-21 (IL-21) belongs to a family of cytokines that includes IL-2, IL-4, IL-7, IL-9, and IL-15, all of which bind to private (or shared) receptors as well as the common cytokine receptor gamma-chain as a component. Most cytokines in this family are critically important for both the maintenance and func...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2008.00631.x
更新日期:2008-06-01 00:00:00
abstract::Although T-cell clones bearing T-cell receptors with high affinity for self-peptide major histocompatibility complex (MHC) products are generally eliminated in the thymus (recessive tolerance), the peripheral T-cell repertoire remains strongly biased toward self-peptide MHC complexes and includes autoreactive T cells....
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2005.00247.x
更新日期:2005-04-01 00:00:00
abstract::B-cell depletion therapy has beneficial effects in autoimmune diseases. This is only partly explained by an elimination of autoantibodies. How does B-cell depletion improve disease? Here, we review preclinical studies showing that B cells can propagate autoimmune disorders through cytokine production. We also highligh...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12374
更新日期:2016-01-01 00:00:00
abstract::The actin cytoskeleton network forms a key link between T-cell antigen receptor (TCR) stimulation and T-cell effector functions, providing a structural basis for T-cell morphological changes and signal transduction. Accumulating evidence positions the Wiskott-Aldrich syndrome protein (WASp), a scaffolding protein that...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12112
更新日期:2013-11-01 00:00:00
abstract::Mutations of the genes encoding T-cell receptor (TCR)-proximal signaling molecules, such as ZAP-70, can be causative of immunological diseases ranging from T-cell immunodeficiency to T-cell-mediated autoimmune disease. For example, SKG mice, which carry a hypomorphic point mutation of the Zap-70 gene, spontaneously de...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12841
更新日期:2020-03-01 00:00:00
abstract::Interleukin-12 (IL-12) and IL-23 share a common chain. Yet, their production in response to pathogens is differentially regulated, and their functions are distinct and often antithetic. IL-12 is involved in the induction or amplification of the T-helper (Th) type 1 response, whereas IL-23 has been associated with the ...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2008.00700.x
更新日期:2008-12-01 00:00:00
abstract:SUMMARY:African trypanosomes are pathogens for humans and livestock. They are single-cell, extra-cellular parasites that cause persistent infections of the blood and induce profound immunosuppression. Here, we review recent work on experimental African trypanosomiasis, especially infections with Trypanosoma congolense,...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2008.00675.x
更新日期:2008-10-01 00:00:00
abstract::Lymphocytes can interfere with the activity of other lymphocytes in a thousand and one ways. A particular subset of so-called regulatory CD4+ T cells is capable of controlling the activity of other lymphocytes in yet another way. Their function is primarily defined by the ability to protect the integrity of tissues an...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2001.1820101.x
更新日期:2001-08-01 00:00:00
abstract::Many tumors express antigens that can be specifically or selectively recognized by T lymphocytes, suggesting that T-cell-mediated immunity may be harnessed for the immunotherapy of cancer. However, since tumors originate from normal cells and evolve within the context of self-tissues, the immune mechanisms that preven...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12166
更新日期:2014-05-01 00:00:00
abstract::TCR repertoire studies in RA have yielded conflicting data. These studies were initiated on the premise that clonal expression of T cells at the site of inflammation could serve as a target for immune therapies designed on the basis of the option to inactivate or eliminate the presumed pathogenic T cells. These analys...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1995.tb00063.x
更新日期:1995-04-01 00:00:00
abstract::Eosinophils play a prominent pro-inflammatory role in allergic inflammation. Studies utilizing flow chambers, intravital video-microscopy, and cytokine and adhesion molecule-deficient mice have provided important insight into the mechanisms of eosinophil trafficking in inflamed blood vessels and into tissues in vivo. ...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2001.790116.x
更新日期:2001-02-01 00:00:00
abstract::The monoclonal antibody, A2B4-2, specifically bound to and inhibited antigen-induced IL-2 release from the cloned pigeon cytochrome c-specific T cell hybrid, 2B4. The initial immunoprecipitation with these reagents demonstrated a protein of 85-90kd on non-reducing conditions, and two bands of 45-50 and 40-44 on reduci...
journal_title:Immunological reviews
pub_type: 杂志文章
doi:10.1111/j.1600-065x.1984.tb01107.x
更新日期:1984-10-01 00:00:00
abstract::Theiler's virus is a picornavirus of mouse which causes an acute encephalomyelitis followed by a persistent infection of the white matter of the spinal cord with chronic inflammation and demyelination. This late disease is studied as a model for multiple sclerosis. Inbred strains of mice differ in their susceptibility...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1997.tb01014.x
更新日期:1997-10-01 00:00:00
abstract::Cancers are able to grow by subverting immune suppressive pathways, to prevent the malignant cells as being recognized as dangerous or foreign. This mechanism prevents the cancer from being eliminated by the immune system and allows disease to progress from a very early stage to a lethal state. Immunotherapies are new...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12528
更新日期:2017-03-01 00:00:00
abstract::In animals and in humans, T-cell therapy can cure advanced disseminated leukemia that would otherwise be fatal. The therapeutic effect of immune T cells is quantitative. As the dose of effector T cells is increased, survival is proportionately increased. Therefore, effective T-cell therapy is predicated on the ability...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1997.tb00982.x
更新日期:1997-06-01 00:00:00
abstract::Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characteri...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12366
更新日期:2015-11-01 00:00:00