Abstract：
:Macrophages play essential roles in tissue homeostasis, pathogen elimination, and tissue repair. A defining characteristic of these cells is their ability to efficiently adapt to a variety of abruptly changing and complex environments. This ability is intrinsically linked to a capacity to quickly alter their transcriptome, and this is tightly associated with the epigenomic organization of these cells and, in particular, their enhancer repertoire. Indeed, enhancers are genomic sites that serve as platforms for the integration of signaling pathways with the mechanisms that regulate mRNA transcription. Notably, transcription is pervasive at active enhancers and enhancer RNAs (eRNAs) are tightly coupled to regulated transcription of protein-coding genes. Furthermore, given that each cell type possesses a defining enhancer repertoire, studies on enhancers provide a powerful method to study how specialization of functions among the diverse macrophage subtypes may arise. Here, we review recent studies providing insights into the distinct mechanisms that contribute to the establishment of enhancers and their role in the regulation of transcription in macrophages.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Gosselin D,Glass CKdoi
10.1111/imr.12213subject
Has Abstractpub_date
2014-11-01 00:00:00pages
96-112issue
1eissn
0105-2896issn
1600-065Xjournal_volume
262pub_type
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1998-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2006-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2018-11-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1999-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12433
更新日期：2016-07-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2009.00853.x
更新日期：2010-01-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12749
更新日期：2019-05-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2013-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2009.00844.x
更新日期：2009-11-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2009-01-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2009-09-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2014-09-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2017-01-01 00:00:00
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更新日期：2014-05-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2011-09-01 00:00:00
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更新日期：2015-03-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2016-07-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2018-05-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2020-09-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2002-07-01 00:00:00
