Abstract:
:Antigenic peptides presented in the context of major histocompatibility complex (MHC) molecules originate from the degradation of both self and non-self proteins. T cells can therefore recognize at the surface of surveyed cells, the self-peptidome produced by the cell itself (mostly inducing tolerance) or immunogenic peptides derived from exogenous origins. The initiation of adaptive immune responses by dendritic cells (DCs), through the antigenic priming of naïve T cells, is associated to microbial pattern recognition receptors engagement. Activation of DCs by microbial product or inflammatory cytokines initiates multiple processes that maximize DC capacity to present exogenous antigens and stimulate T cells by affecting major metabolic and membrane traffic pathways. These include the modulation of protein synthesis, the regulation of MHC and co-stimulatory molecules transport, as well as the regulation of autophagy, that, all together promote exogenous antigen presentation while limiting the display of self-antigens by MHC molecules.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Argüello RJ,Reverendo M,Gatti E,Pierre Pdoi
10.1111/imr.12427subject
Has Abstractpub_date
2016-07-01 00:00:00pages
28-38issue
1eissn
0105-2896issn
1600-065Xjournal_volume
272pub_type
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