Abstract：
:The immune system of the gastrointestinal tract must be tightly regulated to limit pathologic responses toward innocuous antigens while simultaneously allowing for rapid development of effector responses against invading pathogens. Highly specialized antigen-presenting cell (APC) subsets present in the gut play a dominant role in balancing these seemingly disparate functions. In this review, we discuss new findings associated with the function of gut APCs and particularly the contextual role of these cells in both establishing tolerance to orally acquired antigens in the steady state and regulating acute inflammation during infection.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Grainger JR,Askenase MH,Guimont-Desrochers F,da Fonseca DM,Belkaid Ydoi
10.1111/imr.12167subject
Has Abstractpub_date
2014-05-01 00:00:00pages
75-87issue
1eissn
0105-2896issn
1600-065Xjournal_volume
259pub_type
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