The high-affinity receptor for IgG, FcγRI, of humans and non-human primates.

Abstract:

:Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characterization of macaque Fc receptors so far has focused on the low-affinity Fc receptors, particularly FcγRIIIa. From these studies, it is clear that there are distinct differences between the human and macaque low-affinity receptors and their interaction with human IgG. Relatively little work has been performed on the high-affinity IgG receptor, FcγRI, especially in NHPs. This review will focus on what is currently known of how FcγRI interacts with IgG, from mutation studies and recent crystallographic studies of human FcγRI, and how amino acid sequence differences in the macaque FcγRI may affect this interaction. Additionally, this review will look at the functional consequences of differences in the amino acid sequences between humans and macaques.

journal_name

Immunol Rev

journal_title

Immunological reviews

authors

Chenoweth AM,Trist HM,Tan PS,Wines BD,Hogarth PM

doi

10.1111/imr.12366

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

175-91

issue

1

eissn

0105-2896

issn

1600-065X

journal_volume

268

pub_type

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