The high-affinity receptor for IgG, FcγRI, of humans and non-human primates.


:Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characterization of macaque Fc receptors so far has focused on the low-affinity Fc receptors, particularly FcγRIIIa. From these studies, it is clear that there are distinct differences between the human and macaque low-affinity receptors and their interaction with human IgG. Relatively little work has been performed on the high-affinity IgG receptor, FcγRI, especially in NHPs. This review will focus on what is currently known of how FcγRI interacts with IgG, from mutation studies and recent crystallographic studies of human FcγRI, and how amino acid sequence differences in the macaque FcγRI may affect this interaction. Additionally, this review will look at the functional consequences of differences in the amino acid sequences between humans and macaques.


Immunol Rev


Immunological reviews


Chenoweth AM,Trist HM,Tan PS,Wines BD,Hogarth PM




Has Abstract


2015-11-01 00:00:00












  • Insights into immunity from clinical and basic science studies of DOCK8 immunodeficiency syndrome.

    abstract::DOCK8 immunodeficiency syndrome (DIDS) is a progressive combined immunodeficiency that can be distinguished from other combined immunodeficiencies or hyperimmunoglobulinemia E syndromes in featuring (a) profound susceptibility to virus infections of the skin, with associated skin cancers, and (b) severe food allergies...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Su HC,Jing H,Angelus P,Freeman AF

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  • Surface molecules involved in the activation and regulation of T or natural killer lymphocytes in humans.

    abstract::The surface molecules that mediate activation of different subsets of T or NK cells have been reviewed. A suitable approach to the study of different lymphocyte activation pathways is provided by mAbs specific for these molecules. MAbs directed to the CD3 surface molecules mediate a polyclonal T-cell activation, where...

    journal_title:Immunological reviews

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    authors: Moretta A,Ciccone E,Pantaleo G,Tambussi G,Bottino C,Melioli G,Mingari MC,Moretta L

    更新日期:1989-10-01 00:00:00

  • New insights into TB physiology suggest untapped therapeutic opportunities.

    abstract::The current regimens used to treat tuberculosis are largely comprised of serendipitously discovered drugs that are combined based on clinical experience. Despite curing millions, these drug regimens are limited by the long course of therapy, the emergence of resistance, and the persistent tissue damage that remains af...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Baer CE,Rubin EJ,Sassetti CM

    更新日期:2015-03-01 00:00:00

  • Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of Langerhans and the central nervous system.

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    更新日期:1996-08-01 00:00:00

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Waldburger JM,Masternak K,Muhlethaler-Mottet A,Villard J,Peretti M,Landmann S,Reith W

    更新日期:2000-12-01 00:00:00

  • Old dogs-new tricks: immunoregulatory properties of C3 and C5 cleavage fragments.

    abstract::The activation of the complement system by canonical and non-canonical mechanisms results in the generation of multiple C3 and C5 cleavage fragments including anaphylatoxins C3a and C5a as well as opsonizing C3b/iC3b. It is now well appreciated that anaphylatoxins not only act as pro-inflammatory mediators but as immu...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Verschoor A,Karsten CM,Broadley SP,Laumonnier Y,Köhl J

    更新日期:2016-11-01 00:00:00

  • Interplay of innate lymphoid cells and the microbiota.

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Britanova L,Diefenbach A

    更新日期:2017-09-01 00:00:00

  • The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance.

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    更新日期:2008-04-01 00:00:00

  • Cellular carboxypeptidases.

    abstract::This article focuses on four human carboxypeptidases (CPs): two metallo-CPs and two serine CPs. The metallo-CPs are members of the so-called B-type regulatory CP family, as they cleave only the C-terminal basic amino acids Arg or Lys. The plasma membrane-bound CPM and the mainly, but not exclusively, intracellular CPD...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    更新日期:1998-02-01 00:00:00

  • Role of ITAM-containing adapter proteins and their receptors in the immune system and bone.

    abstract::The immunoreceptor tyrosine-based activation motif (ITAM) is a highly conserved region in the cytoplasmic domain of signaling chains and receptors and is a critical mediator of intracellular signals. ITAM-mediated signals depend on the Syk or zeta-associated protein of 70 kDa tyrosine kinases, and ITAM signaling is re...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    更新日期:2005-12-01 00:00:00

  • The role of the preBCR, the interleukin-7 receptor, and homotypic interactions during B-cell development.

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    更新日期:2000-06-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: McGaha TL,Huang L,Lemos H,Metz R,Mautino M,Prendergast GC,Mellor AL

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    更新日期:1998-04-01 00:00:00

  • The role of reactive oxygen species and nitric oxide in mast cell-dependent inflammatory processes.

    abstract::Reactive oxygen species (ROS) and reactive nitrogen oxide species (RNOS), including nitric oxide, are produced in cells by a variety of enzymatic and non-enzymatic mechanisms. At high levels, both types of oxidants are used to kill ingested organisms within phagocytes. At low levels, RNOS may diffuse outside cells whe...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Swindle EJ,Metcalfe DD

    更新日期:2007-06-01 00:00:00

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    abstract::The nuclear hormone receptor retinoid-related orphan receptor γt (RORγt) induces a pro-inflammatory program in lymphoid cells, culminating in the expression of interleukin-6 (IL-6), IL-17, IL-22, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor. During ontogeny, the first type of cells expre...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Eberl G

    更新日期:2012-01-01 00:00:00

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    abstract::The precise mechanisms that govern memory T-cell lineage commitment during an immune response continue to be the subject of intense scrutiny. The existence of memory T-cell subsets defined by location, function, and phenotype adds an additional layer of complexity to the overall memory T-cell population. In this revie...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Lefrançois L

    更新日期:2006-06-01 00:00:00

  • S1PR2 links germinal center confinement and growth regulation.

    abstract::Germinal centers (GCs) are sites of rapid B-cell proliferation and somatic mutation. These ovoid structures develop within the center of follicles and grow to a stereotypic size. The cell migration and interaction dynamics underlying GC B-cell selection events are currently under intense scrutiny. In recent study, we ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Green JA,Cyster JG

    更新日期:2012-05-01 00:00:00

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    abstract:SUMMARY:African trypanosomes are pathogens for humans and livestock. They are single-cell, extra-cellular parasites that cause persistent infections of the blood and induce profound immunosuppression. Here, we review recent work on experimental African trypanosomiasis, especially infections with Trypanosoma congolense,...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Tabel H,Wei G,Shi M

    更新日期:2008-10-01 00:00:00

  • VH-gene representation in autoantibodies reflects the normal human B-cell repertoire.

    abstract::The recurrence in the V-gene repertoire of individual germline VH genes can now be extended from the restricted B-cell populations of the fetus, autoantibodies and B-cell malignancies to the expressed V-gene repertoire of normal adults. Why the human B cell preferentially utilizes these individual VH genes remains spe...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Stewart AK,Huang C,Long AA,Stollar BD,Schwartz RS

    更新日期:1992-08-01 00:00:00

  • Analysis of the B-cell repertoire against antigens expressed by human neoplasms.

    abstract::The screening of tumor-derived expression libraries for antigens detected by high-titer immunoglobulin G antibodies from the sera of patients with cancer by SEREX (serological identification of antigens by recombinant expression cloning) allows a systematic search for antigens of human cancers. SEREX has led to the id...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Preuss KD,Zwick C,Bormann C,Neumann F,Pfreundschuh M

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  • Th1- and Th2-like subsets of innate lymphoid cells.

    abstract::Innate lymphoid cells (ILCs) constitute a family of effectors in innate immunity and regulators of tissue remodeling that have a cytokine and transcription factor expression pattern that parallels that of the T-helper (Th) cell family. Here, we discuss how ILCs can be categorized and summarize the current knowledge of...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Bernink J,Mjösberg J,Spits H

    更新日期:2013-03-01 00:00:00

  • Delineation of the human hematolymphoid system: potential applications of defined cell populations in cellular therapy.

    abstract::Hematopoietic stem cells (HSC) have the capacity to reconstitute all the blood cells in the body. HSC are rare, representing on average 0.05% of the mononuclear cells present in healthy human bone marrow. Due to their capacity for self-renewal and their pluripotent, long-term reconstituting potential, HSC are consider...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Chen BP,Galy AM,Fraser C,Hill B

    更新日期:1997-06-01 00:00:00

  • Therapeutic regulation of T cells in rheumatoid arthritis.

    abstract::TCR repertoire studies in RA have yielded conflicting data. These studies were initiated on the premise that clonal expression of T cells at the site of inflammation could serve as a target for immune therapies designed on the basis of the option to inactivate or eliminate the presumed pathogenic T cells. These analys...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Breedveld FC,Struyk L,van Laar JM,Miltenburg AM,de Vries RR,van den Elsen PJ

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  • Hepatitis regulation by the inflammasome signaling pathway.

    abstract::Hepatitis is damage and inflammation of the liver. It is triggered by both environmental and endogenous insults and is a platform for developing liver cirrhosis and cancer. Both innate and adaptive immune activation contribute to hepatic inflammation and disease. Viral hepatitis is the most common form of hepatitis an...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Negash AA,Gale M Jr

    更新日期:2015-05-01 00:00:00

  • V(D)J recombination: how to tame a transposase.

    abstract::Since the discovery that the recombination-activating gene (RAG) proteins were capable of transposition in vitro, investigators have been trying to uncover instances of transposition in vivo and understand how this transposase has been harnessed to do useful work while being inhibited from causing deleterious chromoso...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Brandt VL,Roth DB

    更新日期:2004-08-01 00:00:00

  • On the ontogeny and physiology of regulatory T cells.

    abstract::Lymphocytes can interfere with the activity of other lymphocytes in a thousand and one ways. A particular subset of so-called regulatory CD4+ T cells is capable of controlling the activity of other lymphocytes in yet another way. Their function is primarily defined by the ability to protect the integrity of tissues an...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Annacker O,Pimenta-Araujo R,Burlen-Defranoux O,Bandeira A

    更新日期:2001-08-01 00:00:00

  • Cell circuits and niches controlling B cell development.

    abstract::Studies over the last decade uncovered overlapping niches for hematopoietic stem cells (HSCs), multipotent progenitor cells, common lymphoid progenitors, and early B cell progenitors. HSC and lymphoid niches are predominantly composed by mesenchymal progenitor cells (MPCs) and by a small subset of endothelial cells. N...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Zehentmeier S,Pereira JP

    更新日期:2019-05-01 00:00:00

  • The linkage between T-cell and dendritic cell development in the mouse thymus.

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Shortman K,Vremec D,Corcoran LM,Georgopoulos K,Lucas K,Wu L

    更新日期:1998-10-01 00:00:00

  • Bronchus- and nasal-associated lymphoid tissues.

    abstract::The bronchus-associated lymphoid tissue (BALT) and the nasal-associated lymphoid tissue (NALT) constitute organized lymphoid aggregates that are capable of T- and B-cell responses to inhaled antigens. BALT, located mostly at bifurcations of the bronchus in animals and humans, is present in the fetus and develops rapid...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Bienenstock J,McDermott MR

    更新日期:2005-08-01 00:00:00

  • T-cell selection in the thymus: a spatial and temporal perspective.

    abstract::The ability of T cells to respond to a wide array of foreign antigens while avoiding reactivity to self is largely determined by cellular selection of developing T cells in the thymus. While a great deal is known about the cell types and molecules involved in T-cell selection in the thymus, our understanding of the sp...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Kurd N,Robey EA

    更新日期:2016-05-01 00:00:00