Regulation of T-cell tolerance by calcium/NFAT signaling.

abstract：:One of the fundamental aspects of the innate immune system is its capacity to discriminate between self and non-self or altered self, and to quickly respond by eliciting effector mechanisms that act in concert to restore normalcy. This capacity is determined by a set of evolutionarily conserved pattern recognition rec...

journal_title：Immunological reviews

authors： Saleh M

更新日期：2011-09-01 00:00:00

abstract：:Once across the barrier of the epithelium, macrophages constitute the primary defense against microbial invasion. For most microbes, the acidic, hydrolytically competent environment of the phagolysosome is sufficient to kill them. Despite our understanding of the trafficking events that regulate phagosome maturation, ...

journal_title：Immunological reviews

authors： Rohde K,Yates RM,Purdy GE,Russell DG

更新日期：2007-10-01 00:00:00

abstract：:Group 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC1s that are engaged during pathogen invasion. We are only beginning to understand the context-dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic pert...

journal_title：Immunological reviews

authors： Adams NM,Sun JC

更新日期：2018-11-01 00:00:00

abstract：:Regulatory T cells (Tregs) and the PD-1: PD-ligand (PD-L) pathway are both critical to terminating immune responses. Elimination of either can result in the breakdown of tolerance and the development of autoimmunity. The PD-1: PD-L pathway can thwart self-reactive T cells and protect against autoimmunity in many ways....

journal_title：Immunological reviews

authors： Francisco LM,Sage PT,Sharpe AH

更新日期：2010-07-01 00:00:00

abstract：:Considerable progress has been made in defining intermediate stages in the process leading from stem cells to mature B cells. Cell-bound and secreted molecules direct the progression through these stages and regulate the selection of clones from which the immune repertoire emerges. In fact, a myriad of signals derived...

journal_title：Immunological reviews

authors： Stoddart A,Fleming HE,Paige CJ

更新日期：2000-06-01 00:00:00

abstract：:Mouse retrovirus-induced lymphoma/leukemia and immunodeficiency are useful models for analogous human diseases. Both ecotropic (mouse tropic) and recombinant retroviruses, including the polytropic mink cytopathic focus-inducing type, have been studied for disease pathogenesis and as targets for humoral and cellular im...

journal_title：Immunological reviews

authors： Green WR

更新日期：1999-04-01 00:00:00

abstract：:Interleukin-12 (IL-12) and IL-23 share a common chain. Yet, their production in response to pathogens is differentially regulated, and their functions are distinct and often antithetic. IL-12 is involved in the induction or amplification of the T-helper (Th) type 1 response, whereas IL-23 has been associated with the ...

journal_title：Immunological reviews

authors： Lyakh L,Trinchieri G,Provezza L,Carra G,Gerosa F

更新日期：2008-12-01 00:00:00

abstract：:This review discusses situations when the magnitude and function of immune responses to virus infection are influenced by regulatory T cells (Tregs). The focus is on CD4+ CD25+ forkhead box protein 3+ natural Tregs (nTregs). The immune response may be limited in magnitude and efficacy when animals with normal nTreg fu...

journal_title：Immunological reviews

authors： Rouse BT,Sarangi PP,Suvas S

更新日期：2006-08-01 00:00:00

abstract：:Eosinophils play a prominent pro-inflammatory role in allergic inflammation. Studies utilizing flow chambers, intravital video-microscopy, and cytokine and adhesion molecule-deficient mice have provided important insight into the mechanisms of eosinophil trafficking in inflamed blood vessels and into tissues in vivo. ...

journal_title：Immunological reviews

authors： Broide D,Sriramarao P

更新日期：2001-02-01 00:00:00

abstract：:Cancer immunotherapy utilizing T-cell checkpoint inhibitors has shown tremendous clinical success. Yet, this mode of treatment is effective in only a subset of patients. Unresponsive patients tend to have non-T-cell-inflamed tumors that lack markers associated with the activation of adaptive anti-tumor immune response...

journal_title：Immunological reviews

authors： Akalu YT,Rothlin CV,Ghosh S

更新日期：2017-03-01 00:00:00

abstract：SUMMARY:B7-H3 and B7-H4 belong to a new class of immune regulatory molecules, which primarily execute their functions in peripheral tissues to fine tune immune responses in target organs. In normal circumstances, while the mRNA for both molecules is broadly distributed, tight control at the post-transcriptional level i...

journal_title：Immunological reviews

authors： Yi KH,Chen L

更新日期：2009-05-01 00:00:00

abstract：:Determination of the crystal structure of class II: peptide complexes has shown that in addition to pocket interactions involving the side chains of the peptide, peptide binding to MHC class II molecules is characterized by a series of hydrogen bonds which are contributed by genetically conserved amino acid residues i...

journal_title：Immunological reviews

authors： Sant AJ,Beeson C,McFarland B,Cao J,Ceman S,Bryant PW,Wu S

更新日期：1999-12-01 00:00:00

abstract：:The precise mechanisms that govern memory T-cell lineage commitment during an immune response continue to be the subject of intense scrutiny. The existence of memory T-cell subsets defined by location, function, and phenotype adds an additional layer of complexity to the overall memory T-cell population. In this revie...

journal_title：Immunological reviews

authors： Lefrançois L

更新日期：2006-06-01 00:00:00

abstract：:There are two distinct pathways by which T cells may recognize MHC alloantigens. The direct pathway involves T-cell recognition of intact MHC molecules expressed by donor antigen-presenting cells (APCs). The second, or indirect, pathway describes T-cell recognition of peptides derived from the processing and presentat...

journal_title：Immunological reviews

authors： Suciu-Foca N,Harris PE,Cortesini R

更新日期：1998-08-01 00:00:00

abstract：:Lymphocytes can interfere with the activity of other lymphocytes in a thousand and one ways. A particular subset of so-called regulatory CD4+ T cells is capable of controlling the activity of other lymphocytes in yet another way. Their function is primarily defined by the ability to protect the integrity of tissues an...

journal_title：Immunological reviews

authors： Annacker O,Pimenta-Araujo R,Burlen-Defranoux O,Bandeira A

更新日期：2001-08-01 00:00:00

abstract：:Ikaros zinc finger transcription factors are important regulators of the gene programs underlying the development of hematopoietic cell lineages. The family consists of five members: Ikaros, Helios, Aiolos, Eos, and Pegasus, which engage in both homo- and heterotypic intrafamilial interactions to exert diverse functio...

journal_title：Immunological reviews

authors： Read KA,Jones DM,Freud AG,Oestreich KJ

更新日期：2020-12-17 00:00:00

abstract：:The tyrosine ZAP-70 (zeta-associated protein of 70 kDa) kinase plays a critical role in activating many downstream signal transduction pathways in T cells following T-cell receptor (TCR) engagement. The importance of ZAP-70 is evidenced by the severe combined immunodeficiency that occurs in ZAP-70-deficient mice and h...

journal_title：Immunological reviews

authors： Au-Yeung BB,Deindl S,Hsu LY,Palacios EH,Levin SE,Kuriyan J,Weiss A

更新日期：2009-03-01 00:00:00

abstract：:The mammalian Dok protein family has seven members (Dok-1-Dok-7). The Dok proteins share structural similarities characterized by the NH2-terminal pleckstrin homology and phosphotyrosine-binding domains followed by SH2 target motifs in the COOH-terminal moiety, indicating an adapter function. Indeed, Dok-1 was origina...

journal_title：Immunological reviews

authors： Mashima R,Hishida Y,Tezuka T,Yamanashi Y

更新日期：2009-11-01 00:00:00

abstract：:Understanding how the integrins on leukocytes operate is important because these receptors control the activity of leukocytes in all phases of their lives. Thus integrins control leukocyte development and maturation in bone marrow, the circulation of naive cells in secondary lymphoid tissue, e.g. the lymph nodes, and ...

journal_title：Immunological reviews

authors： Hogg N,Henderson R,Leitinger B,McDowall A,Porter J,Stanley P

更新日期：2002-08-01 00:00:00

abstract：:Signaling through the interleukin-2 receptor (IL-2R) contributes to T-cell tolerance by controlling three important aspects of regulatory T-cell (Treg) biology. IL-2 is essential for thymic Treg development and regulates Treg homeostasis and suppressive function. Analogous to activated conventional T lymphocytes, IL-2...

journal_title：Immunological reviews

authors： Cheng G,Yu A,Malek TR

更新日期：2011-05-01 00:00:00

abstract：:There is considerable evidence that the conformation and stability of class I and class II major histocompatibility complex (MHC) proteins is dependent upon high-affinity peptide ligation, but structural data for an empty MHC protein unfortunately is lacking. However, several monoclonal antibodies (mAbs) that specific...

journal_title：Immunological reviews

authors： Hansen TH,Lybarger L,Yu L,Mitaksov V,Fremont DH

更新日期：2005-10-01 00:00:00

abstract：:T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLOs) where they provide help to B cells in germinal centers (GCs) to facilitate immunoglobulin affinity maturation, class-switch recom...

journal_title：Immunological reviews

authors： Song W,Craft J

更新日期：2019-03-01 00:00:00

abstract：:One of the most toxic insults a cell can incur is a disruption of its linear DNA in the form of a double-strand break (DSB). Left unrepaired, or repaired improperly, these lesions can result in cell death or neoplastic transformation. Despite these dangers, lymphoid cells purposely introduce DSBs into their genome to ...

journal_title：Immunological reviews

authors： Rooney S,Chaudhuri J,Alt FW

更新日期：2004-08-01 00:00:00

abstract：:The mammalian defense system can respond to a variety of threats, but this capability is not just a simple alarm system for triggering antigen-presenting cells and initiating cellular immunity. Instead, the body is an integrated system in which nearly every cell type can relay the alarm through the production of chemo...

journal_title：Immunological reviews

authors： Lo D,Feng L,Li L,Carson MJ,Crowley M,Pauza M,Nguyen A,Reilly CR

更新日期：1999-06-01 00:00:00

abstract：:For more than a century, immunologists and vaccinologists have existed in parallel universes. Immunologists have for long reveled in using 'model antigens', such as chicken egg ovalbumin or nitrophenyl haptens, to study immune responses in model organisms such as mice. Such studies have yielded many seminal insights a...

journal_title：Immunological reviews

authors： Pulendran B,Oh JZ,Nakaya HI,Ravindran R,Kazmin DA

更新日期：2013-09-01 00:00:00

abstract：:Newfound relatives of the classical Fc receptors (FcR) have been provisionally named the Fc receptor homologs (FcRH). The recent identification of eight human and six mouse FcRH genes substantially increases the size and functional potential of the FcR family. The extended family of FcR and FcRH genes spans approximat...

journal_title：Immunological reviews

authors： Davis RS,Dennis G Jr,Odom MR,Gibson AW,Kimberly RP,Burrows PD,Cooper MD

更新日期：2002-12-01 00:00:00

abstract：:Inoculation of plasmid DNA is a simple way to immunize, but it is characterized by low immunogenicity, which has hampered the development of effective DNA vaccines for human use. Here, we discuss how poor immunogenicity can be solved and present our proposal: genetically programmed B lymphocytes as antigen-presenting ...

journal_title：Immunological reviews

authors： Zanetti M,Castiglioni P,Rizzi M,Wheeler M,Gerloni M

更新日期：2004-06-01 00:00:00

abstract：:The activities of the immune system in repairing tissue injury and combating pathogens were long thought to be independent of the nervous system. However, a major regulatory role of immunomodulatory molecules released locally or systemically by the neuroendocrine system has recently emerged. A number of observations a...

journal_title：Immunological reviews

authors： Quatrini L,Vivier E,Ugolini S

更新日期：2018-11-01 00:00:00

abstract：:MHC class I molecules function to present peptides comprised of eight to 11 residues to CD8+ T lymphocytes. Here we review the efforts of our laboratory to understand how cells generate such peptides from viral gene products. We particularly focus on the nature of substrates acted on by cytosolic proteases, the contri...

journal_title：Immunological reviews

authors： Yewdell J,Antón LC,Bacik I,Schubert U,Snyder HL,Bennink JR

更新日期：1999-12-01 00:00:00

abstract：:Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non-human primates, account for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T-cell subpopulation capable of recognizing the microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by selected pathoge...

journal_title：Immunological reviews

authors： Shen L,Huang D,Qaqish A,Frencher J,Yang R,Shen H,Chen ZW

更新日期：2020-11-01 00:00:00