Mechanical regulation of T-cell functions.

abstract：:In this review, we discuss the possibilities for combining the power of molecular analysis of the antigens expressed in a given individual tumor with the design of a tailored vaccine containing defined antigens. Step 1 is a differential gene expression analysis of tumor and corresponding normal tissue. Step 2 is the a...

journal_title：Immunological reviews

authors： Rammensee HG,Weinschenk T,Gouttefangeas C,Stevanović S

更新日期：2002-10-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) constitute a family of effectors in innate immunity and regulators of tissue remodeling that have a cytokine and transcription factor expression pattern that parallels that of the T-helper (Th) cell family. Here, we discuss how ILCs can be categorized and summarize the current knowledge of...

journal_title：Immunological reviews

authors： Bernink J,Mjösberg J,Spits H

更新日期：2013-03-01 00:00:00

abstract：:Understanding how the integrins on leukocytes operate is important because these receptors control the activity of leukocytes in all phases of their lives. Thus integrins control leukocyte development and maturation in bone marrow, the circulation of naive cells in secondary lymphoid tissue, e.g. the lymph nodes, and ...

journal_title：Immunological reviews

authors： Hogg N,Henderson R,Leitinger B,McDowall A,Porter J,Stanley P

更新日期：2002-08-01 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) are innate immune system cells that play an essential role in eradicating invading pathogens. PMN migration to sites of infection/inflammation requires exiting the microcirculation and subsequent crossing of epithelial barriers in mucosa-lined organs such as the lungs and intestine...

journal_title：Immunological reviews

authors： Brazil JC,Parkos CA

更新日期：2016-09-01 00:00:00

abstract：:TET proteins are DNA demethylases that can oxidize 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC) and other oxidized mC bases (oxi-mCs). Importantly, TET proteins govern cell fate decisions during development of various cell types by activating a cell-specific gene expression program. In this review...

journal_title：Immunological reviews

authors： Tsagaratou A

更新日期：2021-01-07 00:00:00

abstract：:Major histocompatibility complex class II (MHCII) molecules drive the development, activation and homeostasis of CD4* T-helper cells. They play a central role in key processes of the adaptive immune system, such as the generation of T-cell-mediated immune responses, the regulation of antibody production and the develo...

journal_title：Immunological reviews

authors： Waldburger JM,Masternak K,Muhlethaler-Mottet A,Villard J,Peretti M,Landmann S,Reith W

更新日期：2000-12-01 00:00:00

abstract：:For more than a century, immunologists and vaccinologists have existed in parallel universes. Immunologists have for long reveled in using 'model antigens', such as chicken egg ovalbumin or nitrophenyl haptens, to study immune responses in model organisms such as mice. Such studies have yielded many seminal insights a...

journal_title：Immunological reviews

authors： Pulendran B,Oh JZ,Nakaya HI,Ravindran R,Kazmin DA

更新日期：2013-09-01 00:00:00

abstract：:Malaria, caused by the infection with parasites of the germs Plasmodium, is one of the three most important infectious diseases worldwide, along with tuberculosis and infection with human immunodeficiency virus. Natural killer (NK) cells are lymphocytes classically involved in the early defense against viral infection...

journal_title：Immunological reviews

authors： Roetynck S,Baratin M,Johansson S,Lemmers C,Vivier E,Ugolini S

更新日期：2006-12-01 00:00:00

abstract：:Immune responses to gastrointestinal nematodes have been studied extensively for over 80 years and intensively investigated over the last 30-40 years. The use of laboratory models has led to the discovery of new mechanisms of protective immunity and made major contributions to our fundamental understanding of both inn...

journal_title：Immunological reviews

authors： Grencis RK,Humphreys NE,Bancroft AJ

更新日期：2014-07-01 00:00:00

abstract：:Many tumors express antigens that can be specifically or selectively recognized by T lymphocytes, suggesting that T-cell-mediated immunity may be harnessed for the immunotherapy of cancer. However, since tumors originate from normal cells and evolve within the context of self-tissues, the immune mechanisms that preven...

journal_title：Immunological reviews

authors： Savage PA,Leventhal DS,Malchow S

更新日期：2014-05-01 00:00:00

abstract：:Superantigens (SAGs) are a class of disease-causing and immunostimulatory proteins of bacterial or viral origin that activate T cells by binding to the V beta domain of the T-cell antigen receptor (TCR). The three-dimensional structure of the complex between a TCR beta chain (mouse V beta 8.2-J beta 2.1-C beta 1) and ...

journal_title：Immunological reviews

authors： Li H,Llera A,Mariuzza RA

更新日期：1998-06-01 00:00:00

abstract：:On the basis of cell surface markers, mature T cells are considered to have either a naïve or a memory phenotype. These cells exhibit distinct types of kinetic behaviour in vivo. While naïve-phenotype cells persist long term in a non-dividing state, memory-phenotype T cells include cycling cells and exhibit a more rap...

journal_title：Immunological reviews

authors： Tough DF,Sun S,Zhang X,Sprent J

更新日期：1999-08-01 00:00:00

abstract：:In the last decade, the paradigm of primary immunodeficiencies (PIDs) as rare recessive familial diseases that lead to broad, severe, and early-onset immunological defects has shifted toward collectively more common, but sporadic autosomal dominantly inherited isolated defects in the immune response. Patients with PID...

journal_title：Immunological reviews

authors： van der Made CI,Hoischen A,Netea MG,van de Veerdonk FL

更新日期：2020-09-01 00:00:00

abstract：:Antiretroviral therapy (ART) is a life-saving intervention in human immunodeficiency virus (HIV) infection. Immune restoration after ART dramatically reduces the incidence and severity of opportunistic diseases and death. On some occasions, immune restoration may be erratic, leading to acute inflammatory responses (kn...

journal_title：Immunological reviews

authors： Wilson EM,Sereti I

更新日期：2013-07-01 00:00:00

abstract：:Almost four decades of research into the role of human leukocyte antigen-B27 (HLA-B27) in susceptibility to spondyloarthritis has yet to yield a convincing answer. New results from an HLA-B27 transgenic rat model now demonstrate quite convincingly that CD8(+) T cells are not required for the inflammatory phenotype. Di...

journal_title：Immunological reviews

authors： Colbert RA,DeLay ML,Klenk EI,Layh-Schmitt G

更新日期：2010-01-01 00:00:00

abstract：:BCL6 is a transcriptional repressor required in mature B cells during the germinal center (GC) reaction. Multiple mechanisms act coordinately to timely modulate BCL6 expression at transcriptional and post-transcriptional levels. BCL6 prevents premature activation and differentiation of GC B cells and provides an envir...

journal_title：Immunological reviews

authors： Basso K,Dalla-Favera R

更新日期：2012-05-01 00:00:00

abstract：:The mammalian gastrointestinal (GI) tract is colonized by trillions of beneficial commensal bacteria that are essential for promoting normal intestinal physiology. While the majority of commensal bacteria are found in the intestinal lumen, many species have also adapted to colonize different anatomical locations in th...

journal_title：Immunological reviews

authors： Fung TC,Artis D,Sonnenberg GF

更新日期：2014-07-01 00:00:00

abstract：:Adaptive immunity has traditionally been considered a unique feature of vertebrate physiology. Unlike innate immune responses, which remain essentially unchanged upon exposure to a recurrent challenge with the same stimulus, adaptive immune cells possess the ability to learn and remember. Thus, secondary adaptive resp...

journal_title：Immunological reviews

authors： Paust S,Senman B,von Andrian UH

更新日期：2010-05-01 00:00:00

abstract：:DOCK8 immunodeficiency syndrome (DIDS) is a progressive combined immunodeficiency that can be distinguished from other combined immunodeficiencies or hyperimmunoglobulinemia E syndromes in featuring (a) profound susceptibility to virus infections of the skin, with associated skin cancers, and (b) severe food allergies...

journal_title：Immunological reviews

authors： Su HC,Jing H,Angelus P,Freeman AF

更新日期：2019-01-01 00:00:00

abstract：:Germinal centers (GCs) are specialized microenvironments formed after infection where activated B cells can mutate their B-cell receptors to undergo affinity maturation. A stringent process of selection allows high affinity, non-self-reactive B cells to become long-lived memory B cells and plasma cells. While the prec...

journal_title：Immunological reviews

authors： Vinuesa CG,Linterman MA,Goodnow CC,Randall KL

更新日期：2010-09-01 00:00:00

abstract：:The activities of the immune system in repairing tissue injury and combating pathogens were long thought to be independent of the nervous system. However, a major regulatory role of immunomodulatory molecules released locally or systemically by the neuroendocrine system has recently emerged. A number of observations a...

journal_title：Immunological reviews

authors： Quatrini L,Vivier E,Ugolini S

更新日期：2018-11-01 00:00:00

abstract：:The ability of T cells to respond to a wide array of foreign antigens while avoiding reactivity to self is largely determined by cellular selection of developing T cells in the thymus. While a great deal is known about the cell types and molecules involved in T-cell selection in the thymus, our understanding of the sp...

journal_title：Immunological reviews

authors： Kurd N,Robey EA

更新日期：2016-05-01 00:00:00

abstract：:IgG dimers occurring in therapeutic Ig preparations have been characterized as Id-anti-Id, in that the sites of interaction are localized to the distal tips of the Fab arms. The observation that such dimers are prevalent in Ig or Igi.v. prepared from large plasma pools, but absent in preparations from a single individ...

journal_title：Immunological reviews

authors： Tankersley DL

更新日期：1994-06-01 00:00:00

abstract：:A key unresolved challenge for developing an effective HIV-1 vaccine is the discovery of strategies to elicit immune responses that are able to cross-protect against a significant fraction of the diverse viruses that are circulating worldwide. Here, we summarize some of the immunological implications of HIV-1 diversit...

journal_title：Immunological reviews

authors： Korber B,Hraber P,Wagh K,Hahn BH

更新日期：2017-01-01 00:00:00

abstract：SUMMARY:B7-H3 and B7-H4 belong to a new class of immune regulatory molecules, which primarily execute their functions in peripheral tissues to fine tune immune responses in target organs. In normal circumstances, while the mRNA for both molecules is broadly distributed, tight control at the post-transcriptional level i...

journal_title：Immunological reviews

authors： Yi KH,Chen L

更新日期：2009-05-01 00:00:00

abstract：:Experiments with transgenic mice illustrate clonal elimination of T cells specific for antigens expressed appropriately in the thymus, but presence of inducible T cells when the antigen presented on class I MHC antigens is expressed exclusively on non-lymphohemopoietic cells in the periphery (pancreatic beta islet cel...

journal_title：Immunological reviews

authors： Zinkernagel RM,Pircher HP,Ohashi P,Oehen S,Odermatt B,Mak T,Arnheiter H,Bürki K,Hengartner H

更新日期：1991-08-01 00:00:00

abstract：:The infiltration of human tumors by T cells is a common phenomenon, and over the past decades, it has become increasingly clear that the nature of such intratumoral T-cell populations can predict disease course. Furthermore, intratumoral T cells have been utilized therapeutically in clinical studies of adoptive T-cell...

journal_title：Immunological reviews

authors： Linnemann C,Mezzadra R,Schumacher TN

更新日期：2014-01-01 00:00:00

abstract：:The processes of T-cell development and activation employ similar immature and mature receptors as well as similar signal transduction pathways to achieve different outcomes. Many signaling molecules are shared between the receptor signaling pathways, including two families of cytoplasmic protein tyrosine kinases, the...

journal_title：Immunological reviews

authors： Chu DH,Morita CT,Weiss A

更新日期：1998-10-01 00:00:00

abstract：:The age-associated changes in humoral immunity affect the quality more than the quantity of the antibody response. Changes in the quality of the antibody response with age include shifts in antibody specificities from foreign to autoantigens, in antibody isotypes from IgG to IgM, in antibody affinities from high to lo...

journal_title：Immunological reviews

authors： LeMaoult J,Szabo P,Weksler ME

更新日期：1997-12-01 00:00:00

abstract：:This article focuses on four human carboxypeptidases (CPs): two metallo-CPs and two serine CPs. The metallo-CPs are members of the so-called B-type regulatory CP family, as they cleave only the C-terminal basic amino acids Arg or Lys. The plasma membrane-bound CPM and the mainly, but not exclusively, intracellular CPD...

journal_title：Immunological reviews

authors： Skidgel RA,Erdös EG

更新日期：1998-02-01 00:00:00