Abstract:
:The infiltration of human tumors by T cells is a common phenomenon, and over the past decades, it has become increasingly clear that the nature of such intratumoral T-cell populations can predict disease course. Furthermore, intratumoral T cells have been utilized therapeutically in clinical studies of adoptive T-cell therapy. In this review, we describe how novel methods that are either based on T-cell receptor (TCR) sequencing or on cancer exome analysis allow the analysis of the tumor reactivity and antigen-specificity of the intratumoral TCR repertoire with unprecedented detail. Furthermore, we discuss studies that have started to utilize these techniques to probe the link between cancer exomes and the intratumoral TCR pool. Based on the observation that both the cancer epitope repertoire and intratumoral TCR repertoire appear highly individual, we outline strategies, such as 'autologous TCR gene therapy', that exploit the tumor-resident TCR repertoire for the development of personalized immunotherapy.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Linnemann C,Mezzadra R,Schumacher TNdoi
10.1111/imr.12140subject
Has Abstractpub_date
2014-01-01 00:00:00pages
72-82issue
1eissn
0105-2896issn
1600-065Xjournal_volume
257pub_type
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journal_title:Immunological reviews
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journal_title:Immunological reviews
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journal_title:Immunological reviews
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更新日期:2004-02-01 00:00:00
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journal_title:Immunological reviews
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更新日期:1989-08-01 00:00:00
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journal_title:Immunological reviews
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更新日期:2004-08-01 00:00:00
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journal_title:Immunological reviews
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更新日期:1998-12-01 00:00:00
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更新日期:2000-10-01 00:00:00