Abstract:
:The biological roles of two interferon-inducible chemokines, monokine induced by gamma interferon (Mig) and cytokine responsive gene (Crg-2), in the immune response against vaccinia virus (VV) and ectromelia virus (EV) infections are discussed. To investigate their antiviral effects in vivo, the expression profiles of these chemokines during the course of VV or EV infections were first established. Mig and Crg-2 were induced in multiple organs at high levels early after infection with VV. Both chemokines were rapidly induced in popliteal lymph nodes of C57BL/6 mice but not in BALB/c mice following infection with EV. Secondly, recombinant vaccinia viruses (rVV) encoding Mig or Crg-2 were constructed to investigate the immunobiology of infection in athymic, nude and euthymic, normal mice. Finally, the EV model in combination with recombinant Mig and Crg-2 proteins was used to test their effects on viral replication and immune responses in vivo. The results of these investigations demonstrate that the mechanisms of Mig- and Crg-2-induced viral clearance involve natural killer cells and interferons.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Mahalingam S,Foster PS,Lobigs M,Farber JM,Karupiah Gdoi
10.1034/j.1600-065x.2000.17720.xkeywords:
subject
Has Abstractpub_date
2000-10-01 00:00:00pages
127-33eissn
0105-2896issn
1600-065Xjournal_volume
177pub_type
杂志文章,评审abstract::In spite of some remarkable progress in our understanding of the immune response to parasites and in the molecular cloning of dozens of genes encoding for potentially protective proteins, no definitive step has yet been made towards operational vaccines against major human parasitic diseases. The reasons for our prese...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1989.tb00551.x
更新日期:1989-12-01 00:00:00
abstract::Because of its intrinsic virulence, Toxoplasma gondii induces a potent interleukin-12 (IL-12)-dependent cell-mediated immune response that shuts down the growth of the replicative tachyzoite stage, thus promoting host survival and successful transmission through predation. At the same time, this response must be tight...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2004.00179.x
更新日期:2004-10-01 00:00:00
abstract::Natural killer cells express multiple receptors for major histocompatibility complex (MHC) class I, including the killer cell immunoglobulin-like receptors (KIRs) and the C-type lectin-like CD94:NKG2 receptors. The KIR locus is extremely polymorphic, paralleling the diversity of its classical MHC class I ligands. Simi...
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pub_type: 杂志文章,评审
doi:10.1111/imr.12315
更新日期:2015-09-01 00:00:00
abstract::Resistance to infection with Listeria monocytogenes involves a series of cellular interactions, many of which are carried out by cytokines. Macrophages, NK cells and neutrophils participate in early stages of Listeria resistance. The neutrophil is specially important for clearance of the liver phase of listeriosis. Ma...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1997.tb00988.x
更新日期:1997-08-01 00:00:00
abstract::Chemokines control selective targeting of circulating leukocytes to the microvasculature by triggering inside-out signal transduction pathways leading to integrin-dependent adhesion. Integrin activation by chemokines is very rapid, is downmodulated within minutes and appears to involve both enhanced heterodimer latera...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
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更新日期:2002-08-01 00:00:00
abstract::We have discussed four specific models which provide different kinds of information about the requirements for T cell activation. The first utilized a CTL clone designated L3, which is reactive specifically with Ld alloantigen, to study the involvement of the associative recognition structure Lyt-2 in cytolysis. The a...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1984.tb01105.x
更新日期:1984-10-01 00:00:00
abstract::During the past several years, we have been studying the circulating TCR gamma delta cells expressed in peripheral lymphoid tissues. Biochemical and molecular characterization of the TCR gamma delta heterodimers present on these TCR gamma delta cells identified 3 TCR gamma proteins, V gamma 2-C gamma 1, V gamma 1.2-C ...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1991.tb00585.x
更新日期:1991-04-01 00:00:00
abstract::Since the discovery that the recombination-activating gene (RAG) proteins were capable of transposition in vitro, investigators have been trying to uncover instances of transposition in vivo and understand how this transposase has been harnessed to do useful work while being inhibited from causing deleterious chromoso...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2004.00161.x
更新日期:2004-08-01 00:00:00
abstract::Immunity results from a complex interplay between the antigen-non-specific innate immune system and the antigen-specific adaptive immune system. The cells and molecules of the innate system employ non-clonal recognition receptors including lectins, Toll-like receptors, NOD-like receptors, and helicases. B and T lympho...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2009.00884.x
更新日期:2010-03-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2002.18805.x
更新日期:2002-10-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12082
更新日期:2013-07-01 00:00:00
abstract::In mice, the absence of terminal deoxynucleotidyl transferase (Tdt) expression during fetal and neonatal life provides a window in development where clones of lymphocytes are generated that provide protective immunity. Introducing premature Tdt activity interferes with the development of these clones and results in an...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:
更新日期:2000-06-01 00:00:00
abstract::Studies in the last 20 years have given us a remarkable insight into the functional and phenotypic diversity of macrophages which reflects their integral role in host defence, homeostasis and pathogenesis. Mouse genetics, transcriptomic and epigenetic studies have provided an ontogenic and molecular perspective to the...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12603
更新日期:2017-11-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2005.00230.x
更新日期:2005-02-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2006.00391.x
更新日期:2006-06-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12559
更新日期:2017-07-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1989.tb00028.x
更新日期:1989-08-01 00:00:00
abstract::Idiotypic networks, after being a dominating paradigm for more than a decade, have fallen out of fashion in parallel with the rapid success of molecular immunobiology. Today signs of a possible renaissance in idiotypic network studies are visible. For system biologists and also for physicists, the network idea remains...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2006.00496.x
更新日期:2007-04-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2001.1830108.x
更新日期:2001-10-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2010.00909.x
更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1111/imr.12528
更新日期:2017-03-01 00:00:00
abstract::More than 20 years ago, immunologists discovered that resistance and susceptibility to experimental infection with the intracellular protozoan Leishmania major was associated with the development of T-helper 1 (Th1)- and Th2-dominated immune responses, respectively. This infectious disease model was later used to iden...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
abstract::The cellular communications between a human CD4+ clone and autologous CD4+ clones induced with the first clone are described. The autoreactive clones proliferated after stimulation with the inducer clone, but not after stimulation with autologous clones expressing irrelevant specificities. The inducer clone markedly l...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1990.tb00804.x
更新日期:1990-08-01 00:00:00
abstract::Peptides derived from parasites are presented to T helper cells by major histocompatibility complex (MHC) class II alpha beta heterodimeric cell-surface molecules. In mice and humans, the genes encoding these antigen-presenting molecules are known to be polymorphic and polygenic. Multiple loci for MHC class II A and B...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1998.tb01270.x
更新日期:1998-12-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12464
更新日期:2016-11-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1995.tb00063.x
更新日期:1995-04-01 00:00:00
abstract::Experiments designed to identify all HLA class I genes led to the cloning of the HLA-G gene (Geraghty et al. 1987). Very low levels of HLA-G mRNA expression have been demonstrated in the eye, thymus, peripheral blood lymphocytes and in keratinocytes (Shukla et al. 1990, Ishitani & Geraghty 1992, Kirszenbaum et al. 199...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1995.tb00087.x
更新日期:1995-10-01 00:00:00
abstract::Natural killer (NK) cells of inbred mice reject allogeneic bone-marrow cells, and NK cells of F1 hybrid mice can reject parental bone-marrow cells (hybrid resistance). In some cases these patterns of rejection can be mimicked in vitro by utilizing IL-2 cultured NK effector cells and allogeneic or parental T-lymphoblas...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1997.tb00937.x
更新日期:1997-02-01 00:00:00
abstract::The age-associated changes in humoral immunity affect the quality more than the quantity of the antibody response. Changes in the quality of the antibody response with age include shifts in antibody specificities from foreign to autoantigens, in antibody isotypes from IgG to IgM, in antibody affinities from high to lo...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1997.tb01032.x
更新日期:1997-12-01 00:00:00