Abstract：
:The innate immune system is an evolutionarily ancient form of host defense found in most multicellular organisms. Inducible responses of the innate immune system are triggered upon pathogen recognition by a set of pattern recognition receptors. These receptors recognize conserved molecular patterns shared by large groups of microorganisms. Recognition of these patterns allows the innate immune system not only to detect the presence of an infectious microbe, but also to determine the type of the infecting pathogen. Pattern recognition receptors activate conserved host defense signaling pathways that control the expression of a variety of immune response genes.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Medzhitov R,Janeway C Jrdoi
10.1034/j.1600-065x.2000.917309.xkeywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
89-97eissn
0105-2896issn
1600-065Xjournal_volume
173pub_type
杂志文章,评审abstract：:Since the discovery that the recombination-activating gene (RAG) proteins were capable of transposition in vitro, investigators have been trying to uncover instances of transposition in vivo and understand how this transposase has been harnessed to do useful work while being inhibited from causing deleterious chromoso...
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journal_title：Immunological reviews
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更新日期：1984-04-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2001-12-01 00:00:00
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