Stimulation of naïve and memory T cells by cytokines.

Abstract:

:On the basis of cell surface markers, mature T cells are considered to have either a naïve or a memory phenotype. These cells exhibit distinct types of kinetic behaviour in vivo. While naïve-phenotype cells persist long term in a non-dividing state, memory-phenotype T cells include cycling cells and exhibit a more rapid rate of turnover; this has also been shown to be true for cells that can be definitively identified as naïve or memory T cells respectively. The number of memory-phenotype (CD44hi) CD8+ T cells entering cell cycle is greatly increased after in vivo exposure to viruses, bacteria or components of bacteria. Accelerated turnover of memory T cells also occurs after the injection of a variety cytokines that are induced by infectious agents, including type I interferon (IFN-I). Although naïve-phenotype T cells do not divide in response to these cytokines, they do exhibit signs of activation, including upregulation of CD69 after exposure to IFN-I. These findings suggest that the dissimilar in vivo kinetics of naïve- and memory-phenotype T cells might reflect their divergent responses to cytokines. Furthermore, the ability of infection-induced cytokines to stimulate non-specific proliferation of memory-phenotype T cells and partial activation of naïve-phenotype T cells implies that they play a complex role during primary immune responses to infectious agents.

journal_name

Immunol Rev

journal_title

Immunological reviews

authors

Tough DF,Sun S,Zhang X,Sprent J

doi

10.1111/j.1600-065x.1999.tb01327.x

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

39-47

eissn

0105-2896

issn

1600-065X

journal_volume

170

pub_type

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