T-cell selection in the thymus: a spatial and temporal perspective.

abstract：:The monoclonal antibody, A2B4-2, specifically bound to and inhibited antigen-induced IL-2 release from the cloned pigeon cytochrome c-specific T cell hybrid, 2B4. The initial immunoprecipitation with these reagents demonstrated a protein of 85-90kd on non-reducing conditions, and two bands of 45-50 and 40-44 on reduci...

journal_title：Immunological reviews

authors： Samelson LE,Schwartz RH

更新日期：1984-10-01 00:00:00

abstract：:A detailed analysis of the genes and proteins that participate in the murine immune response to PC has provided key insights at the structural level into the phenomenon of somatic mutation in B cells. Most anti-PC antibodies are encoded by 1 VH gene of the S107 subfamily, and 3 VK genes, VKT15 of the VK22 subfamily, V...

journal_title：Immunological reviews

authors： Malipiero UV,Levy NS,Gearhart PJ

更新日期：1987-04-01 00:00:00

abstract：:For more than a century, immunologists and vaccinologists have existed in parallel universes. Immunologists have for long reveled in using 'model antigens', such as chicken egg ovalbumin or nitrophenyl haptens, to study immune responses in model organisms such as mice. Such studies have yielded many seminal insights a...

journal_title：Immunological reviews

authors： Pulendran B,Oh JZ,Nakaya HI,Ravindran R,Kazmin DA

更新日期：2013-09-01 00:00:00

abstract：:The interferon-gamma (IFN-gamma)/interleukin-12 (IL-12) pathway is a pivotal player in the immune system and is central to controlling mycobacterial infections. We highlight the most recent and relevant advances in understanding this pathway and their repercussions on basic and clinical science. Human mutations in IFN...

journal_title：Immunological reviews

authors： Rosenzweig SD,Holland SM

更新日期：2005-02-01 00:00:00

abstract：:Theiler's virus is a picornavirus of mouse which causes an acute encephalomyelitis followed by a persistent infection of the white matter of the spinal cord with chronic inflammation and demyelination. This late disease is studied as a model for multiple sclerosis. Inbred strains of mice differ in their susceptibility...

journal_title：Immunological reviews

authors： Monteyne P,Bureau JF,Brahic M

更新日期：1997-10-01 00:00:00

abstract：:Hematopoietic stem cell transplantation has been used for more than 50 years to combat hematologic malignancies. In addition to being the first stem cell therapy, transplantation has provided evidence for the potent anti-tumor effects of T cells. Facilitating T-cell-based immunity against malignancies requires a caref...

journal_title：Immunological reviews

authors： Ghosh A,Holland AM,van den Brink MR

更新日期：2014-01-01 00:00:00

abstract：:In addition to its effects on sexual differentiation and reproduction, estrogen has important impact on the immune system and on bone. It has also been evident that the effects of estrogen on bone to a large extent are mediated via its action on immune cells. Estrogen has a dichotomous impact on the immune system by d...

journal_title：Immunological reviews

authors： Carlsten H

更新日期：2005-12-01 00:00:00

abstract：:There are two distinct pathways by which T cells may recognize MHC alloantigens. The direct pathway involves T-cell recognition of intact MHC molecules expressed by donor antigen-presenting cells (APCs). The second, or indirect, pathway describes T-cell recognition of peptides derived from the processing and presentat...

journal_title：Immunological reviews

authors： Suciu-Foca N,Harris PE,Cortesini R

更新日期：1998-08-01 00:00:00

abstract：:Mouse retrovirus-induced lymphoma/leukemia and immunodeficiency are useful models for analogous human diseases. Both ecotropic (mouse tropic) and recombinant retroviruses, including the polytropic mink cytopathic focus-inducing type, have been studied for disease pathogenesis and as targets for humoral and cellular im...

journal_title：Immunological reviews

authors： Green WR

更新日期：1999-04-01 00:00:00

abstract：:Over the past 20 years, major progress has been made in our understanding of natural killer (NK) cells. It has become clear that NK cells are regulated by a number of receptors with opposite functions that finely tune potent effector functions such as cytolytic activity and release of cytokines that play a major role ...

journal_title：Immunological reviews

authors： Moretta A,Locatelli F,Moretta L

更新日期：2008-08-01 00:00:00

abstract：:The discovery of the autoimmune regulator (AIRE) protein and the delineation of its critical contributions in the establishment of central immune tolerance has significantly expanded our understanding of the immunological mechanisms that protect from the development of autoimmune disease. The parallel identification a...

journal_title：Immunological reviews

authors： Constantine GM,Lionakis MS

更新日期：2019-01-01 00:00:00

abstract：:Almost four decades of research into the role of human leukocyte antigen-B27 (HLA-B27) in susceptibility to spondyloarthritis has yet to yield a convincing answer. New results from an HLA-B27 transgenic rat model now demonstrate quite convincingly that CD8(+) T cells are not required for the inflammatory phenotype. Di...

journal_title：Immunological reviews

authors： Colbert RA,DeLay ML,Klenk EI,Layh-Schmitt G

更新日期：2010-01-01 00:00:00

abstract：:In the last decade, the paradigm of primary immunodeficiencies (PIDs) as rare recessive familial diseases that lead to broad, severe, and early-onset immunological defects has shifted toward collectively more common, but sporadic autosomal dominantly inherited isolated defects in the immune response. Patients with PID...

journal_title：Immunological reviews

authors： van der Made CI,Hoischen A,Netea MG,van de Veerdonk FL

更新日期：2020-09-01 00:00:00

abstract：:The surface molecules that mediate activation of different subsets of T or NK cells have been reviewed. A suitable approach to the study of different lymphocyte activation pathways is provided by mAbs specific for these molecules. MAbs directed to the CD3 surface molecules mediate a polyclonal T-cell activation, where...

journal_title：Immunological reviews

authors： Moretta A,Ciccone E,Pantaleo G,Tambussi G,Bottino C,Melioli G,Mingari MC,Moretta L

更新日期：1989-10-01 00:00:00

abstract：:Recent studies on autoimmune ovarian disease (AOD) induced by thymectomy on d3 (d3tx), and AOD induced by immunization with the ovary-specific zona pellucida 3 peptide (pZP3), have yielded the following results. First, female tolerance to pZP3 depends on the persistence of endogenous antigen (Ag). Second, following re...

journal_title：Immunological reviews

authors： Tung KS,Agersborg SS,Alard P,Garza KM,Lou YH

更新日期：2001-08-01 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) are innate immune system cells that play an essential role in eradicating invading pathogens. PMN migration to sites of infection/inflammation requires exiting the microcirculation and subsequent crossing of epithelial barriers in mucosa-lined organs such as the lungs and intestine...

journal_title：Immunological reviews

authors： Brazil JC,Parkos CA

更新日期：2016-09-01 00:00:00

abstract：:One of the biggest barriers to achieving allograft tolerance is the presence of immunological memory within the recipient, which confers a faster, more robust immune response that is in most cases more resistant to pharmacologic immunosuppression. This review will identify the mechanisms by which alloreactive T cells ...

journal_title：Immunological reviews

authors： Hartigan CR,Sun H,Ford ML

更新日期：2019-11-01 00:00:00

abstract：:Solid tumor therapy with chemotherapeutics greatly depends on the efficiency with which drugs are delivered to tumor cells. The typical characteristics of the tumor physiology promote but also appose accumulation of blood-borne agents. The leaky tumor vasculature allows easy passage of drugs. However, the disorganized...

journal_title：Immunological reviews

authors： ten Hagen TL,Seynhaeve AL,Eggermont AM

更新日期：2008-04-01 00:00:00

abstract：:The immune system is capable of recognizing and eliminating an enormous array of pathogens due to the extremely diverse antigen receptor repertoire of T and B lymphocytes. However, the development of lymphocytes bearing receptors with unique specificities requires the generation of programmed double strand breaks (DSB...

journal_title：Immunological reviews

authors： Matei IR,Guidos CJ,Danska JS

更新日期：2006-02-01 00:00:00

abstract：:Newfound relatives of the classical Fc receptors (FcR) have been provisionally named the Fc receptor homologs (FcRH). The recent identification of eight human and six mouse FcRH genes substantially increases the size and functional potential of the FcR family. The extended family of FcR and FcRH genes spans approximat...

journal_title：Immunological reviews

authors： Davis RS,Dennis G Jr,Odom MR,Gibson AW,Kimberly RP,Burrows PD,Cooper MD

更新日期：2002-12-01 00:00:00

abstract：:Human immunodeficiency virus infection is still one of the most important causes of morbidity and mortality in the world, with a disproportionate human and economic burden especially in poorer countries. Despite many years of intense research, an aspect that still is not well understood is what (immune) mechanisms con...

journal_title：Immunological reviews

authors： Cardozo EF,Apetrei C,Pandrea I,Ribeiro RM

更新日期：2018-09-01 00:00:00

abstract：:Malaria, caused by the infection with parasites of the germs Plasmodium, is one of the three most important infectious diseases worldwide, along with tuberculosis and infection with human immunodeficiency virus. Natural killer (NK) cells are lymphocytes classically involved in the early defense against viral infection...

journal_title：Immunological reviews

authors： Roetynck S,Baratin M,Johansson S,Lemmers C,Vivier E,Ugolini S

更新日期：2006-12-01 00:00:00

abstract：:Inflammasomes are multiprotein complexes that control the maturation and production of interleukin-1 family members and play crucial roles in host defense against pathogens. However, dysregulated activation of inflammasomes is associated with intense inflammation, leading to the development of inflammatory diseases. T...

journal_title：Immunological reviews

authors： Takahama M,Akira S,Saitoh T

更新日期：2018-01-01 00:00:00

abstract：:Group 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC1s that are engaged during pathogen invasion. We are only beginning to understand the context-dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic pert...

journal_title：Immunological reviews

authors： Adams NM,Sun JC

更新日期：2018-11-01 00:00:00

abstract：:TET proteins are DNA demethylases that can oxidize 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC) and other oxidized mC bases (oxi-mCs). Importantly, TET proteins govern cell fate decisions during development of various cell types by activating a cell-specific gene expression program. In this review...

journal_title：Immunological reviews

authors： Tsagaratou A

更新日期：2021-01-07 00:00:00

abstract：:A successful immune response depends on the migration of lymphocytes into lymph nodes or inflamed tissues where they make contact with antigen-presenting cells. We are interested in how one member of the integrin family, leukocyte function-associated antigen-1 (LFA-1), controls the function and, in particular, the mig...

journal_title：Immunological reviews

authors： Smith A,Stanley P,Jones K,Svensson L,McDowall A,Hogg N

更新日期：2007-08-01 00:00:00

abstract：:Interest in DNA immunization of animals continues, despite the fact that immune responses induced by DNA vaccines are generally lower than those elicited by conventional vaccines. In attempts to enhance the immune response to DNA vaccines, individuals have tried a variety of immune modulators, cytokines, and costimula...

journal_title：Immunological reviews

authors： van Drunen Littel-van den Hurk S,Babiuk SL,Babiuk LA

更新日期：2004-06-01 00:00:00

abstract：:Ubiquitination is a post-translational modification process that regulates several critical cellular processes. Ubiquitination is orchestrated by the ubiquitin proteasome system (UPS), which constitutes a cascade of enzymes that transfer ubiquitin onto protein substrates. The UPS catalyzes the destruction of many crit...

journal_title：Immunological reviews

authors： Sahasrabuddhe AA,Elenitoba-Johnson KS

更新日期：2015-01-01 00:00:00

abstract：:Unique Vγ2Vδ2 (Vγ9Vδ2) T cells existing only in human and non-human primates, account for the majority of circulating γδ T cells in human adults. Vγ2Vδ2 T cells are the sole γδ T-cell subpopulation capable of recognizing the microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by selected pathoge...

journal_title：Immunological reviews

authors： Shen L,Huang D,Qaqish A,Frencher J,Yang R,Shen H,Chen ZW

更新日期：2020-11-01 00:00:00

abstract：:Hepatitis is damage and inflammation of the liver. It is triggered by both environmental and endogenous insults and is a platform for developing liver cirrhosis and cancer. Both innate and adaptive immune activation contribute to hepatic inflammation and disease. Viral hepatitis is the most common form of hepatitis an...

journal_title：Immunological reviews

authors： Negash AA,Gale M Jr

更新日期：2015-05-01 00:00:00