Abstract:
:In this review, we discuss the possibilities for combining the power of molecular analysis of the antigens expressed in a given individual tumor with the design of a tailored vaccine containing defined antigens. Step 1 is a differential gene expression analysis of tumor and corresponding normal tissue. Step 2 is the analysis of human leukocyte antigen (HLA) ligands on tumor cells. Step 3 is data mining with the aim to select those antigens that might be suitable for tumor attack by the adaptive immune system. Step 4 is the on-the-spot clinical grade production of the constituents of the patient tailored vaccine, e.g. peptides. Step 5 is then vaccination and monitoring. Although it will not be possible to cover all relevant antigens expressed in a tumor, the antigens that can be identified with our present technical possibilities might be enough for improved immunotherapy. The scope of the present review is to explore the possibilities and the formidable technical and logistical challenge for such individual patient-oriented antigen definition to be used for therapeutic immunization.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Rammensee HG,Weinschenk T,Gouttefangeas C,Stevanović Sdoi
10.1034/j.1600-065x.2002.18815.xkeywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
164-76eissn
0105-2896issn
1600-065Xpii
imr18815journal_volume
188pub_type
杂志文章,评审abstract::Human immunodeficiency virus infection is still one of the most important causes of morbidity and mortality in the world, with a disproportionate human and economic burden especially in poorer countries. Despite many years of intense research, an aspect that still is not well understood is what (immune) mechanisms con...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12691
更新日期:2018-09-01 00:00:00
abstract::The recurrence in the V-gene repertoire of individual germline VH genes can now be extended from the restricted B-cell populations of the fetus, autoantibodies and B-cell malignancies to the expressed V-gene repertoire of normal adults. Why the human B cell preferentially utilizes these individual VH genes remains spe...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1992.tb00834.x
更新日期:1992-08-01 00:00:00
abstract::Fcγ receptors (FcγRs) are key immune receptors responsible for the effective control of both humoral and innate immunity and are central to maintaining the balance between generating appropriate responses to infection and preventing autoimmunity. When this balance is lost, pathology results in increased susceptibility...
journal_title:Immunological reviews
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doi:10.1111/imr.12341
更新日期:2015-11-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2009.00797.x
更新日期:2009-07-01 00:00:00
abstract:SUMMARY:Dengue viruses (DENV) are the mosquito-borne viruses of greatest global public health importance. DENV circulate as four serotypes with significant immunologic cross-reactivity that does not provide protection from secondary infection with heterologous serotypes. The strong association of severe dengue illness,...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2008.00678.x
更新日期:2008-10-01 00:00:00
abstract::As biomedical research becomes increasingly data-intensive, it is increasingly essential to integrate genomic-scale datasets, so as to generate a more holistic picture of complex biological processes. The systems biology paradigm may differ in strategy from traditional reductionist scientific methods, but the goal rem...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2010.00998.x
更新日期:2011-03-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2005.00299.x
更新日期:2005-08-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12940
更新日期:2021-01-07 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2012.01112.x
更新日期:2012-05-01 00:00:00
abstract::Cell transplantation and tissue regeneration studies indicate a surprisingly broad developmental potential for lineage-committed hematopoietic stem cells (HSCs). Under these conditions HSCs transition into myocytes, neurons, hepatocytes or other types of nonhematopoietic effector cells. Equally impressive is the progr...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2002.18703.x
更新日期:2002-09-01 00:00:00
abstract::Experiments with transgenic mice illustrate clonal elimination of T cells specific for antigens expressed appropriately in the thymus, but presence of inducible T cells when the antigen presented on class I MHC antigens is expressed exclusively on non-lymphohemopoietic cells in the periphery (pancreatic beta islet cel...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1991.tb00601.x
更新日期:1991-08-01 00:00:00
abstract::The actin cytoskeleton network forms a key link between T-cell antigen receptor (TCR) stimulation and T-cell effector functions, providing a structural basis for T-cell morphological changes and signal transduction. Accumulating evidence positions the Wiskott-Aldrich syndrome protein (WASp), a scaffolding protein that...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12112
更新日期:2013-11-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1046/j.1600-065x.2003.00088.x
更新日期:2003-12-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12186
更新日期:2014-07-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1998.tb01204.x
更新日期:1998-08-01 00:00:00
abstract::Schistosomiasis is a serious global helminthic disease, in which the main immunopathology consists of a granulomatous and fibrosing reaction against tissue-trapped parasite eggs. The severity of this inflammatory process, the product of a CD4(+) T-cell-mediated immune response against parasite egg antigens, is, howeve...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2004.00197.x
更新日期:2004-10-01 00:00:00
abstract::The discovery of the autoimmune regulator (AIRE) protein and the delineation of its critical contributions in the establishment of central immune tolerance has significantly expanded our understanding of the immunological mechanisms that protect from the development of autoimmune disease. The parallel identification a...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12714
更新日期:2019-01-01 00:00:00
abstract::The immune system is capable of recognizing and eliminating an enormous array of pathogens due to the extremely diverse antigen receptor repertoire of T and B lymphocytes. However, the development of lymphocytes bearing receptors with unique specificities requires the generation of programmed double strand breaks (DSB...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2006.00361.x
更新日期:2006-02-01 00:00:00
abstract::X-linked lymphoproliferative disease (XLP) is an inherited immune defect caused by mutations in the Src homology 2 domain-containing gene 1A, which encodes the adapter protein, signaling lymphocytic activation molecule (SLAM)-associated protein (SAP). SAP is expressed in T cells, natural killer (NK) cells, and NKT cel...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2005.00230.x
更新日期:2005-02-01 00:00:00
abstract::Inflammasomes are multiprotein complexes that control the maturation and production of interleukin-1 family members and play crucial roles in host defense against pathogens. However, dysregulated activation of inflammasomes is associated with intense inflammation, leading to the development of inflammatory diseases. T...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12613
更新日期:2018-01-01 00:00:00
abstract::A detailed analysis of the genes and proteins that participate in the murine immune response to PC has provided key insights at the structural level into the phenomenon of somatic mutation in B cells. Most anti-PC antibodies are encoded by 1 VH gene of the S107 subfamily, and 3 VK genes, VKT15 of the VK22 subfamily, V...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1987.tb00509.x
更新日期:1987-04-01 00:00:00
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journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12213
更新日期:2014-11-01 00:00:00
abstract::In the non-obese diabetic (NOD) mouse, a Th1-biased autoimmune response arises spontaneously against glutamic acid decarboxylase, concurrent with the onset of insulitis. Subsequently, Th1-type autoreactivity spreads intra- and intermolecularly to other beta-cell autoantigens (beta CAAs), suggesting that a spontaneous ...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1998.tb01214.x
更新日期:1998-08-01 00:00:00
abstract::Self-tolerance is achieved by deleting or regulating self-reactive lymphocytes at a series of cellular checkpoints placed at many points along the developmental pathways to plasma cells and effector T cells. At each checkpoint, what are the molecular pathways that determine whether a lymphocyte remains quiescent, begi...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1034/j.1600-065x.2000.00614.x
更新日期:2000-08-01 00:00:00
abstract::Experiments designed to identify all HLA class I genes led to the cloning of the HLA-G gene (Geraghty et al. 1987). Very low levels of HLA-G mRNA expression have been demonstrated in the eye, thymus, peripheral blood lymphocytes and in keratinocytes (Shukla et al. 1990, Ishitani & Geraghty 1992, Kirszenbaum et al. 199...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065x.1995.tb00087.x
更新日期:1995-10-01 00:00:00
abstract::Interest in DNA immunization of animals continues, despite the fact that immune responses induced by DNA vaccines are generally lower than those elicited by conventional vaccines. In attempts to enhance the immune response to DNA vaccines, individuals have tried a variety of immune modulators, cytokines, and costimula...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.0105-2896.2004.00140.x
更新日期:2004-06-01 00:00:00
abstract::Cancer cells are subjected to constant selection by the immune system, meaning that tumors that become clinically manifest have managed to subvert or hide from immunosurveillance. Immune control can be facilitated by induction of autophagy, as well as by polyploidization of cancer cells. While autophagy causes the rel...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/imr.12582
更新日期:2017-11-01 00:00:00
abstract::Reactive oxygen species (ROS) and reactive nitrogen oxide species (RNOS), including nitric oxide, are produced in cells by a variety of enzymatic and non-enzymatic mechanisms. At high levels, both types of oxidants are used to kill ingested organisms within phagocytes. At low levels, RNOS may diffuse outside cells whe...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2007.00513.x
更新日期:2007-06-01 00:00:00
abstract::Increasing evidence suggests that mast cells (MCs), in addition to acute allergic reactions, are involved in the pathogenesis of chronic inflammatory diseases and in particular in rheumatoid arthritis (RA). MCs reside in connective tissues and in synovial tissue of joints. They produce an array of proinflammatory medi...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2007.00504.x
更新日期:2007-06-01 00:00:00
abstract::Systems biology is the comprehensive and quantitative analysis of the interactions between all of the components of biological systems over time. Systems biology involves an iterative cycle, in which emerging biological problems drive the development of new technologies and computational tools. These technologies and ...
journal_title:Immunological reviews
pub_type: 杂志文章,评审
doi:10.1111/j.1600-065X.2008.00721.x
更新日期:2009-01-01 00:00:00