Fcγ receptors: genetic variation, function, and disease.


:Fcγ receptors (FcγRs) are key immune receptors responsible for the effective control of both humoral and innate immunity and are central to maintaining the balance between generating appropriate responses to infection and preventing autoimmunity. When this balance is lost, pathology results in increased susceptibility to cancer, autoimmunity, and infection. In contrast, optimal FcγR engagement facilitates effective disease resolution and response to monoclonal antibody immunotherapy. The underlying genetics of the FcγR gene family are a central component of this careful balance. Complex in humans and generated through ancestral duplication events, here we review the evolution of the gene family in mammals, the potential importance of copy number, and functionally relevant single nucleotide polymorphisms, as well as discussing current approaches and limitations when exploring genetic variation in this region.


Immunol Rev


Immunological reviews


Hargreaves CE,Rose-Zerilli MJ,Machado LR,Iriyama C,Hollox EJ,Cragg MS,Strefford JC




Has Abstract


2015-11-01 00:00:00












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    abstract::Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-kappaB and mitogen-activated pro...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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  • Innate immune recognition: mechanisms and pathways.

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Medzhitov R,Janeway C Jr

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  • T-cell clones that react against autologous human tumors.

    abstract::T cells (derived from peripheral blood lymphocytes [PBL], lymph nodes or tumor tissues and restimulated with autologous tumor cells and expanded in interleukin-2 [IL-2]), when cloned, produce three functional classes of clone. Class I T-cell clones exhibit the phenotype of alpha/beta cytotoxic T lymphocytes (CD3+, CD8...

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    pub_type: 杂志文章,评审


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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Allavena P,Sica A,Garlanda C,Mantovani A

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Mathew A,Rothman AL

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    更新日期:2001-04-01 00:00:00

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    pub_type: 杂志文章,评审


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    更新日期:2008-10-01 00:00:00

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    更新日期:1993-06-01 00:00:00

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    pub_type: 杂志文章,评审


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    更新日期:2020-12-17 00:00:00

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    pub_type: 杂志文章,评审


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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    更新日期:2018-01-01 00:00:00

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Rohde K,Yates RM,Purdy GE,Russell DG

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    abstract::The endosomal pathway of antigen presentation leads to the display of peptides on major histocompatibility complex (MHC) class II molecules at the cell surface of antigen-presenting cells (APCs). The pathway involves two major steps, invariant chain degradation and antigen processing, which take place in the late endo...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Hsing LC,Rudensky AY

    更新日期:2005-10-01 00:00:00

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Humphrey MB,Lanier LL,Nakamura MC

    更新日期:2005-12-01 00:00:00

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Malipiero UV,Levy NS,Gearhart PJ

    更新日期:1987-04-01 00:00:00

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    abstract::The characterization of the microenvironment of human tumors led to the description of tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T-cell zone adjacent to B-cell follicle including a germinal center. TLS represent sites of lymphoid neogenesis that develop in most solid cancers. Anal...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Dieu-Nosjean MC,Giraldo NA,Kaplon H,Germain C,Fridman WH,Sautès-Fridman C

    更新日期:2016-05-01 00:00:00

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    abstract::The number of possible T cell activation outcomes resulting from T cell receptor (TCR) engagement suggests that the TCR is able to differentially activate a myriad of signaling pathways depending on the nature of the stimulus. The complex structural organization of the TCR itself could underlie this diversity of respo...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Alarcón B,Gil D,Delgado P,Schamel WW

    更新日期:2003-02-01 00:00:00

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    abstract::T follicular helper (Tfh) cells play a crucial role in orchestrating the humoral arm of adaptive immune responses. Mature Tfh cells localize to follicles in secondary lymphoid organs (SLOs) where they provide help to B cells in germinal centers (GCs) to facilitate immunoglobulin affinity maturation, class-switch recom...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Song W,Craft J

    更新日期:2019-03-01 00:00:00

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    abstract::There is considerable evidence that the conformation and stability of class I and class II major histocompatibility complex (MHC) proteins is dependent upon high-affinity peptide ligation, but structural data for an empty MHC protein unfortunately is lacking. However, several monoclonal antibodies (mAbs) that specific...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Hansen TH,Lybarger L,Yu L,Mitaksov V,Fremont DH

    更新日期:2005-10-01 00:00:00

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    abstract::Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characteri...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Chenoweth AM,Trist HM,Tan PS,Wines BD,Hogarth PM

    更新日期:2015-11-01 00:00:00

  • Spatial and temporal coordination of antiviral responses by group 1 ILCs.

    abstract::Group 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC1s that are engaged during pathogen invasion. We are only beginning to understand the context-dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic pert...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Adams NM,Sun JC

    更新日期:2018-11-01 00:00:00

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    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Ettinger R,Kuchen S,Lipsky PE

    更新日期:2008-06-01 00:00:00

  • Occult persistence and lymphotropism of hepadnaviral infection: insights from the woodchuck viral hepatitis model.

    abstract::Hepatitis B virus (HBV) is a major human pathogen that causes chronic infection and life-threatening liver diseases in millions of individuals. While pathological and epidemiological consequences of clinically evident HBV infections are well recognized, there is no similar knowledge on an asymptomatic, silently progre...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Michalak TI

    更新日期:2000-04-01 00:00:00

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    abstract::Cell transplantation and tissue regeneration studies indicate a surprisingly broad developmental potential for lineage-committed hematopoietic stem cells (HSCs). Under these conditions HSCs transition into myocytes, neurons, hepatocytes or other types of nonhematopoietic effector cells. Equally impressive is the progr...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: French SW,Hoyer KK,Shen RR,Teitell MA

    更新日期:2002-09-01 00:00:00

  • Functions of purified L3T4+ and Lyt-2+ cells in vitro and in vivo.

    abstract::The expression of L3T4 and Lyt-2 cell surface molecules separates T cells into two broad, non-overlapping subsets: typical T helper cells are L3T4+ Lyt-2- whereas most T killer cells and their precursors are L3T4- Lyt-2+. This review compares highly purified populations of unprimed L3T4+ and Lyt-2+ cells for their cap...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Sprent J,Schaefer M,Lo D,Korngold R

    更新日期:1986-06-01 00:00:00