Fcγ receptors: genetic variation, function, and disease.


:Fcγ receptors (FcγRs) are key immune receptors responsible for the effective control of both humoral and innate immunity and are central to maintaining the balance between generating appropriate responses to infection and preventing autoimmunity. When this balance is lost, pathology results in increased susceptibility to cancer, autoimmunity, and infection. In contrast, optimal FcγR engagement facilitates effective disease resolution and response to monoclonal antibody immunotherapy. The underlying genetics of the FcγR gene family are a central component of this careful balance. Complex in humans and generated through ancestral duplication events, here we review the evolution of the gene family in mammals, the potential importance of copy number, and functionally relevant single nucleotide polymorphisms, as well as discussing current approaches and limitations when exploring genetic variation in this region.


Immunol Rev


Immunological reviews


Hargreaves CE,Rose-Zerilli MJ,Machado LR,Iriyama C,Hollox EJ,Cragg MS,Strefford JC




Has Abstract


2015-11-01 00:00:00












  • NK cells: tuned by peptide?

    abstract::Natural killer cells express multiple receptors for major histocompatibility complex (MHC) class I, including the killer cell immunoglobulin-like receptors (KIRs) and the C-type lectin-like CD94:NKG2 receptors. The KIR locus is extremely polymorphic, paralleling the diversity of its classical MHC class I ligands. Simi...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Das J,Khakoo SI

    更新日期:2015-09-01 00:00:00

  • Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infection.

    abstract::Because of its intrinsic virulence, Toxoplasma gondii induces a potent interleukin-12 (IL-12)-dependent cell-mediated immune response that shuts down the growth of the replicative tachyzoite stage, thus promoting host survival and successful transmission through predation. At the same time, this response must be tight...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Aliberti J,Jankovic D,Sher A

    更新日期:2004-10-01 00:00:00

  • Memory T-cell exhaustion and tolerance in transplantation.

    abstract::One of the biggest barriers to achieving allograft tolerance is the presence of immunological memory within the recipient, which confers a faster, more robust immune response that is in most cases more resistant to pharmacologic immunosuppression. This review will identify the mechanisms by which alloreactive T cells ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Hartigan CR,Sun H,Ford ML

    更新日期:2019-11-01 00:00:00

  • Negative regulation of lymphocyte development and function by the Cbl family of proteins.

    abstract::Negative regulation of intracellular signaling delivered by the antigen receptors and coreceptors plays an important role in lymphocyte development and activation. Recent data from our laboratory and others have identified the Cbl family of ubiquitin ligases as important negative regulators in both T-cell and B-cell a...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Huang F,Gu H

    更新日期:2008-08-01 00:00:00

  • Obesity and CD8 T cell metabolism: Implications for anti-tumor immunity and cancer immunotherapy outcomes.

    abstract::Obesity is an established risk factor for many cancers and has recently been found to alter the efficacy of T cell-based immunotherapies. Currently, however, the effects of obesity on immunometabolism remain unclear. Understanding these associations is critical, given the fact that T cell metabolism is tightly linked ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Turbitt WJ,Buchta Rosean C,Weber KS,Norian LA

    更新日期:2020-05-01 00:00:00

  • Cytoplasmic DNA innate immune pathways.

    abstract::The innate immune system is responsible for detecting microbial invasion of the cell and for stimulating host defense countermeasures. These anti-pathogen procedures include the transcriptional activation of powerful antiviral genes such as the type I interferons (IFNs) or the triggering of inflammatory responses thro...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Barber GN

    更新日期:2011-09-01 00:00:00

  • On the ontogeny and physiology of regulatory T cells.

    abstract::Lymphocytes can interfere with the activity of other lymphocytes in a thousand and one ways. A particular subset of so-called regulatory CD4+ T cells is capable of controlling the activity of other lymphocytes in yet another way. Their function is primarily defined by the ability to protect the integrity of tissues an...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Annacker O,Pimenta-Araujo R,Burlen-Defranoux O,Bandeira A

    更新日期:2001-08-01 00:00:00

  • The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance.

    abstract::An intrinsic (oncogene-driven) pathway and an extrinsic (microenvironment-driven) pathway connect inflammatory reactions and cancer. M2-polarized tumor-associated macrophages and the related myeloid-derived suppressor cells are key prototypic components of smoldering inflammation driving neoplastic progression. Howeve...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Allavena P,Sica A,Garlanda C,Mantovani A

    更新日期:2008-04-01 00:00:00

  • Regulatory T cells in virus infections.

    abstract::This review discusses situations when the magnitude and function of immune responses to virus infection are influenced by regulatory T cells (Tregs). The focus is on CD4+ CD25+ forkhead box protein 3+ natural Tregs (nTregs). The immune response may be limited in magnitude and efficacy when animals with normal nTreg fu...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Rouse BT,Sarangi PP,Suvas S

    更新日期:2006-08-01 00:00:00

  • The intra- and extracellular functions of ASC specks.

    abstract::Inflammasomes are the central signaling hubs of the inflammatory response. They process cytosolic evidence of infection, cell damage, or metabolic disturbances, and elicit a pro-inflammatory response mediated by members of the interleukin-1 family of cytokines and pyroptotoic cell death. On the molecular level, this i...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Franklin BS,Latz E,Schmidt FI

    更新日期:2018-01-01 00:00:00

  • Autoreactive responses to pyruvate dehydrogenase complex in the pathogenesis of primary biliary cirrhosis.

    abstract::Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by immune-mediated destruction of the biliary epithelial cells (BEC) lining the intrahepatic bile ducts (non-suppurative destructive cholangitis (NSDC)). Autoantibody and autoreactive T-cell responses specific for the self-antigen pyruvate de...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Yeaman SJ,Kirby JA,Jones DE

    更新日期:2000-04-01 00:00:00

  • Immune memory redefined: characterizing the longevity of natural killer cells.

    abstract::Natural killer (NK) cells respond rapidly to transformed, stressed, or virally infected cells and provide a first-line immune defense against pathogen invasion and cancer. Thought to involve short-lived effector cells that are armed for battle, NK cells were not previously known to contribute in recall responses to pa...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Sun JC,Beilke JN,Lanier LL

    更新日期:2010-07-01 00:00:00

  • T-cell clones that react against autologous human tumors.

    abstract::T cells (derived from peripheral blood lymphocytes [PBL], lymph nodes or tumor tissues and restimulated with autologous tumor cells and expanded in interleukin-2 [IL-2]), when cloned, produce three functional classes of clone. Class I T-cell clones exhibit the phenotype of alpha/beta cytotoxic T lymphocytes (CD3+, CD8...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Mukherji B,Chakraborty NG,Sivanandham M

    更新日期:1990-08-01 00:00:00

  • Autophagy limits activation of the inflammasomes.

    abstract::Inflammasomes are multiprotein complexes that control the maturation and production of interleukin-1 family members and play crucial roles in host defense against pathogens. However, dysregulated activation of inflammasomes is associated with intense inflammation, leading to the development of inflammatory diseases. T...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Takahama M,Akira S,Saitoh T

    更新日期:2018-01-01 00:00:00

  • The high-affinity receptor for IgG, FcγRI, of humans and non-human primates.

    abstract::Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characteri...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Chenoweth AM,Trist HM,Tan PS,Wines BD,Hogarth PM

    更新日期:2015-11-01 00:00:00

  • Somatic hypermutation in normal and transformed human B cells.

    abstract::In the human, most IgM+IgD+ as well as CD5+ peripheral blood B cells express unmutated V genes and thus can be assigned to a pre-germinal centre (GC) stage of development. The memory B-cell compartment generated in the GC reaction and characterized by cells bearing somatically mutated V-region genes consists not only ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Klein U,Goossens T,Fischer M,Kanzler H,Braeuninger A,Rajewsky K,Küppers R

    更新日期:1998-04-01 00:00:00

  • Multifaceted effects of Francisella tularensis on human neutrophil function and lifespan.

    abstract::Francisella tularensis in an intracellular bacterial pathogen that causes a potentially lethal disease called tularemia. Studies performed nearly 100 years ago revealed that neutrophil accumulation in infected tissues correlates directly with the extent of necrotic damage during F. tularensis infection. However, the d...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Kinkead LC,Allen LA

    更新日期:2016-09-01 00:00:00

  • The development of effector and memory T cells in cutaneous leishmaniasis: the implications for vaccine development.

    abstract::Leishmania major infections induce the development of a CD4(+) T-helper 1 (Th1) response that not only controls the primary infection but also results in life-long immunity to reinfection. How that immunity is maintained is unknown, although because of the existence of infection-induced immunity, there has been an ass...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Scott P,Artis D,Uzonna J,Zaph C

    更新日期:2004-10-01 00:00:00

  • T-cell costimulatory pathways in allograft rejection and tolerance.

    abstract::The destiny of activated T cells is critical to the ultimate fate of immune response. After encountering antigen, naïve T cells receive signal 1 through the T-cell receptor (TCR)-major histocompatibility complex (MHC) plus antigenic peptide complex and signal 2 through "positive" costimulatory molecules leading to ful...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Rothstein DM,Sayegh MH

    更新日期:2003-12-01 00:00:00

  • Deciphering the multifaceted roles of TET proteins in T-cell lineage specification and malignant transformation.

    abstract::TET proteins are DNA demethylases that can oxidize 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC) and other oxidized mC bases (oxi-mCs). Importantly, TET proteins govern cell fate decisions during development of various cell types by activating a cell-specific gene expression program. In this review...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Tsagaratou A

    更新日期:2021-01-07 00:00:00

  • Hepatitis regulation by the inflammasome signaling pathway.

    abstract::Hepatitis is damage and inflammation of the liver. It is triggered by both environmental and endogenous insults and is a platform for developing liver cirrhosis and cancer. Both innate and adaptive immune activation contribute to hepatic inflammation and disease. Viral hepatitis is the most common form of hepatitis an...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Negash AA,Gale M Jr

    更新日期:2015-05-01 00:00:00

  • Adrenal 21-hydroxylase cytochrome P-450 genes within the MHC class III region.

    abstract::Genes encoding several serum complement components and the gene(s) for steroid 21-hydroxylase (21-OH) have been located in the class III region of the major histocompatibility complex (MHC). All these genes are highly polymorphic in man, and these polymorphisms have been used to draw conclusions about the structure an...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: White PC,New MI,Dupont B

    更新日期:1985-10-01 00:00:00

  • Cellular immune reactions in the lung.

    abstract::The lung constantly interacts with the environment through thousands of liters of air that are inhaled daily. This continually transports toxic chemicals and particles or pathogenic microorganisms deep into the respiratory system, posing a challenge to physicochemical barriers and the local immune system. Thus, comple...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Hasenberg M,Stegemann-Koniszewski S,Gunzer M

    更新日期:2013-01-01 00:00:00

  • Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans.

    abstract::Interleukin-12 (IL-12) and IL-23 share a common chain. Yet, their production in response to pathogens is differentially regulated, and their functions are distinct and often antithetic. IL-12 is involved in the induction or amplification of the T-helper (Th) type 1 response, whereas IL-23 has been associated with the ...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Lyakh L,Trinchieri G,Provezza L,Carra G,Gerosa F

    更新日期:2008-12-01 00:00:00

  • Systems serology for evaluation of HIV vaccine trials.

    abstract::The scale and scope of the global epidemic, coupled to challenges with traditional vaccine development approaches, point toward a need for novel methodologies for HIV vaccine research. While the development of vaccines able to induce broadly neutralizing antibodies remains the ultimate goal, to date, vaccines continue...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Ackerman ME,Barouch DH,Alter G

    更新日期:2017-01-01 00:00:00

  • Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.

    abstract::X-linked lymphoproliferative disease (XLP) is an inherited immune defect caused by mutations in the Src homology 2 domain-containing gene 1A, which encodes the adapter protein, signaling lymphocytic activation molecule (SLAM)-associated protein (SAP). SAP is expressed in T cells, natural killer (NK) cells, and NKT cel...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Nichols KE,Ma CS,Cannons JL,Schwartzberg PL,Tangye SG

    更新日期:2005-02-01 00:00:00

  • Genomic and funtional aspects of the rat MHC, the RT1 complex.

    abstract::The major histocompatibility complex (MHC) plays a central role in controlling immune responsiveness, susceptibility to certain diseases and histo-incompatibility. A physical map of the complete rat MHC, the RTI complex, is presented based on a PAC clonal contig (RT1n haplotype). Expression profiling of various tissue...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Dressel R,Walter L,Günther E

    更新日期:2001-12-01 00:00:00

  • Stimulation of naïve and memory T cells by cytokines.

    abstract::On the basis of cell surface markers, mature T cells are considered to have either a naïve or a memory phenotype. These cells exhibit distinct types of kinetic behaviour in vivo. While naïve-phenotype cells persist long term in a non-dividing state, memory-phenotype T cells include cycling cells and exhibit a more rap...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Tough DF,Sun S,Zhang X,Sprent J

    更新日期:1999-08-01 00:00:00

  • Molecular basis of host-parasite relationship: towards the definition of protective antigens.

    abstract::In spite of some remarkable progress in our understanding of the immune response to parasites and in the molecular cloning of dozens of genes encoding for potentially protective proteins, no definitive step has yet been made towards operational vaccines against major human parasitic diseases. The reasons for our prese...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Capron A,Dessaint JP

    更新日期:1989-12-01 00:00:00

  • Generating MHC class I ligands from viral gene products.

    abstract::MHC class I molecules function to present peptides comprised of eight to 11 residues to CD8+ T lymphocytes. Here we review the efforts of our laboratory to understand how cells generate such peptides from viral gene products. We particularly focus on the nature of substrates acted on by cytosolic proteases, the contri...

    journal_title:Immunological reviews

    pub_type: 杂志文章,评审


    authors: Yewdell J,Antón LC,Bacik I,Schubert U,Snyder HL,Bennink JR

    更新日期:1999-12-01 00:00:00