Abstract：
:Fcγ receptors (FcγRs) are key immune receptors responsible for the effective control of both humoral and innate immunity and are central to maintaining the balance between generating appropriate responses to infection and preventing autoimmunity. When this balance is lost, pathology results in increased susceptibility to cancer, autoimmunity, and infection. In contrast, optimal FcγR engagement facilitates effective disease resolution and response to monoclonal antibody immunotherapy. The underlying genetics of the FcγR gene family are a central component of this careful balance. Complex in humans and generated through ancestral duplication events, here we review the evolution of the gene family in mammals, the potential importance of copy number, and functionally relevant single nucleotide polymorphisms, as well as discussing current approaches and limitations when exploring genetic variation in this region.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Hargreaves CE,Rose-Zerilli MJ,Machado LR,Iriyama C,Hollox EJ,Cragg MS,Strefford JCdoi
10.1111/imr.12341subject
Has Abstractpub_date
2015-11-01 00:00:00pages
6-24issue
1eissn
0105-2896issn
1600-065Xjournal_volume
268pub_type
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