Abstract：
:A byproduct of the largely stochastic generation of a diverse B-cell specificity repertoire is production of cells that recognize autoantigens. Indeed, recent studies indicate that more than half of the primary repertoire consists of autoreactive B cells that must be silenced to prevent autoimmunity. While this silencing can occur by multiple mechanisms, it appears that most autoreactive B cells are silenced by anergy, wherein they populate peripheral lymphoid organs and continue to express unoccupied antigen receptors yet are unresponsive to antigen stimulation. Here we review molecular mechanisms that appear operative in maintaining the antigen unresponsiveness of anergic B cells. In addition, we present new data indicating that the failure of anergic B cells to mobilize calcium in response to antigen stimulation is not mediated by inactivation of stromal interacting molecule 1, a critical intermediary in intracellular store depletion-induced calcium influx.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Yarkoni Y,Getahun A,Cambier JCdoi
10.1111/j.1600-065X.2010.00936.xsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
249-63issue
1eissn
0105-2896issn
1600-065Xpii
IMR936journal_volume
237pub_type
杂志文章,评审abstract：:Rabbits have helped elucidate one of the major immunologic puzzles, namely the genetic control of antibody diversity. The primary IgH antibody repertoire in rabbits is dominated by B cells that use the same germline VH-gene segment in VDJ gene rearrangements. The VDJ genes of essentially all B lymphocytes undergo soma...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1998-04-01 00:00:00
abstract：:Newfound relatives of the classical Fc receptors (FcR) have been provisionally named the Fc receptor homologs (FcRH). The recent identification of eight human and six mouse FcRH genes substantially increases the size and functional potential of the FcR family. The extended family of FcR and FcRH genes spans approximat...
journal_title：Immunological reviews
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journal_title：Immunological reviews
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doi：10.1111/j.1600-065X.2008.00640.x
更新日期：2008-06-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2007-10-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1034/j.1600-065x.2001.1840104.x
更新日期：2001-12-01 00:00:00
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更新日期：2001-06-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2006.00412.x
更新日期：2006-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12112
更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2006.00348.x
更新日期：2006-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2000-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2009.00877.x
更新日期：2010-03-01 00:00:00
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更新日期：2011-07-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1999.tb01381.x
更新日期：1999-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2010.00900.x
更新日期：2010-07-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2004-06-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2009-01-01 00:00:00
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更新日期：2008-10-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2016-03-01 00:00:00
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更新日期：2015-11-01 00:00:00
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更新日期：2015-01-01 00:00:00
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更新日期：2002-09-01 00:00:00
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更新日期：2019-01-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2016-09-01 00:00:00
abstract：:IgG dimers occurring in therapeutic Ig preparations have been characterized as Id-anti-Id, in that the sites of interaction are localized to the distal tips of the Fab arms. The observation that such dimers are prevalent in Ig or Igi.v. prepared from large plasma pools, but absent in preparations from a single individ...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1994.tb00861.x
更新日期：1994-06-01 00:00:00
abstract：:The pivotal discovery that two chemokine receptors, CCR5 and CXCR4, serve along with the T-cell receptor-interacting CD4 molecule as the principal co-receptors for HIV-1 entry stimulated a search for common genetic polymorphism in their genes which might affect the course of AIDS. Four mutational variants, CCR5-delta3...
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pub_type： 杂志文章,评审
doi：10.1034/j.1600-065x.2000.17710.x
更新日期：2000-10-01 00:00:00
