Abstract：
:Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-kappaB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. In this review, we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the role of Nlrc4, Nlpr1, and Nlrp3 inflammasomes in caspase-1 activation and subsequent release of proinflammatory cytokines such as interleukin-1 beta.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Franchi L,Warner N,Viani K,Nuñez Gdoi
10.1111/j.1600-065X.2008.00734.xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
106-28issue
1eissn
0105-2896issn
1600-065Xpii
IMR734journal_volume
227pub_type
杂志文章,评审abstract：:The pivotal discovery that two chemokine receptors, CCR5 and CXCR4, serve along with the T-cell receptor-interacting CD4 molecule as the principal co-receptors for HIV-1 entry stimulated a search for common genetic polymorphism in their genes which might affect the course of AIDS. Four mutational variants, CCR5-delta3...
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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更新日期：2011-07-01 00:00:00
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更新日期：2010-05-01 00:00:00
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更新日期：2000-12-01 00:00:00
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更新日期：2004-12-01 00:00:00
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更新日期：2019-01-01 00:00:00
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更新日期：1997-12-01 00:00:00
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更新日期：2015-09-01 00:00:00
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