Abstract：
:Idiotypic networks, after being a dominating paradigm for more than a decade, have fallen out of fashion in parallel with the rapid success of molecular immunobiology. Today signs of a possible renaissance in idiotypic network studies are visible. For system biologists and also for physicists, the network idea remains attractive. Herein, a short account of the historical development of the paradigm is given. The necessary technical and conceptual ingredients for a theoretical description of idiotypic networks are briefly reviewed, and previous approaches are discussed. We also describe a minimalistic model developed in our group that allows for understanding the random evolution toward a highly non-trivial complex architecture. In the network, a connected large cluster of idiotype clones and many disconnected ones coexist, thus resembling the notion of central and peripheral parts proposed in the 'second-generation' version of the paradigm. The connected cluster consists of groups of idiotypic clones with clearly distinct statistical properties. The simplicity of the model allows for calculating the size of the groups and the number of inter- and intragroup links, which define the architecture. Aspects of idiotypic interactions in experimental medicine are discussed, along with the challenges to theory and experimentation.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Behn Udoi
10.1111/j.1600-065X.2006.00496.xsubject
Has Abstractpub_date
2007-04-01 00:00:00pages
142-52eissn
0105-2896issn
1600-065Xpii
IMR496journal_volume
216pub_type
杂志文章,评审abstract：:Interleukin-12 (IL-12) and IL-23 share a common chain. Yet, their production in response to pathogens is differentially regulated, and their functions are distinct and often antithetic. IL-12 is involved in the induction or amplification of the T-helper (Th) type 1 response, whereas IL-23 has been associated with the ...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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journal_title：Immunological reviews
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更新日期：1991-12-01 00:00:00
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journal_title：Immunological reviews
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pub_type： 杂志文章,评审
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更新日期：1999-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2006-10-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2003-12-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1997.tb00982.x
更新日期：1997-06-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2006-02-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2008.00721.x
更新日期：2009-01-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2007-10-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2014-05-01 00:00:00
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更新日期：2002-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1998-02-01 00:00:00
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更新日期：1999-12-01 00:00:00
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更新日期：2016-11-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1998.tb01447.x
更新日期：1998-04-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2005-10-01 00:00:00
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更新日期：2011-05-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1990-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章
doi：10.1111/j.1600-065x.1986.tb01167.x
更新日期：1986-12-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1998.tb01270.x
更新日期：1998-12-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2012-05-01 00:00:00
abstract：:Almost four decades of research into the role of human leukocyte antigen-B27 (HLA-B27) in susceptibility to spondyloarthritis has yet to yield a convincing answer. New results from an HLA-B27 transgenic rat model now demonstrate quite convincingly that CD8(+) T cells are not required for the inflammatory phenotype. Di...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.0105-2896.2009.00865.x
更新日期：2010-01-01 00:00:00
