Abstract：
:Hematopoietic stem cell transplantation has been used for more than 50 years to combat hematologic malignancies. In addition to being the first stem cell therapy, transplantation has provided evidence for the potent anti-tumor effects of T cells. Facilitating T-cell-based immunity against malignancies requires a careful balancing act between generating a robust response and avoiding off-target killing of healthy tissues, which is difficult to accomplish using bulk donor T cells. To address these issues, several approaches have been developed, drawing on basic T-cell biology, to potentiate graft-versus-tumor activity while avoiding graft-versus-host disease. Current strategies for anti-tumor cell therapies include: (i) selecting optimal T cells for transfer; (ii) engineering T cells to possess enhanced effector functions; and (iii) generating T-cell precursors that complete development after adoptive transfer. In this review, we assess the current state of the art in T-lineage cell therapy to treat malignancies in the context of allogeneic hematopoietic stem cell transplantation.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Ghosh A,Holland AM,van den Brink MRdoi
10.1111/imr.12142subject
Has Abstractpub_date
2014-01-01 00:00:00pages
226-36issue
1eissn
0105-2896issn
1600-065Xjournal_volume
257pub_type
杂志文章,评审abstract：:NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the kille...
journal_title：Immunological reviews
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journal_title：Immunological reviews
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pub_type： 杂志文章,评审
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
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更新日期：1997-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2005-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2013-07-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065X.2011.01045.x
更新日期：2011-09-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1998.tb01238.x
更新日期：1998-10-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/imr.12166
更新日期：2014-05-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2004-10-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2001-04-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2009-05-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1999-12-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2017-11-01 00:00:00
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更新日期：2017-09-01 00:00:00
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更新日期：2016-11-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2019-11-01 00:00:00
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journal_title：Immunological reviews
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doi：10.1111/j.1600-065x.1991.tb00615.x
更新日期：1991-12-01 00:00:00
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更新日期：2007-10-01 00:00:00
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更新日期：1999-02-01 00:00:00
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journal_title：Immunological reviews
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更新日期：1996-08-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2001-08-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：2017-07-01 00:00:00
abstract：:Complement is a humoral factor of innate immunity and plays important roles in immune surveillance and clearance of invading pathogens. Mammalian complement consists of the classical (antibody-dependent), the alternative (antibody-independent) and the lectin (triggered by mannose-binding lectin) pathways of activation...
journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1998.tb01250.x
更新日期：1998-12-01 00:00:00
