Abstract：
:Mice infected with Listeria monocytogenes (LM) generate protective CD8 cells of varying specificity. One subset, unlike conventional LM-immune CD8 cells, can respond to antigen-presenting cells (APC) treated with heat-killed LM (HKLM). These cells proved to have surprisingly uniform specificity, recognizing a product we designated HKLM-associated antigen (HAA) presented by the non-classical class Ib product H2-M3wt. HAA proved to be extremely hydrophobic and the bioactive portion of the molecule was highly protease-resistant, leading us initially to speculate that it might be a non-peptide. Recent studies, however, identify HAA as a complex containing lemA, a listerial protein bearing the immunogenic amino terminal peptide sequence fMIGWII, tightly associated with bacterial cardiolipin. A variety of cell types can process and present exogenous HAA/lemA, and the phospholipid component appears essential for this processing. Endosomal acidification and proteolysis are required for processing, but the site where antigen binds to H2-M3wt within APC remains uncertain. HAA/lemA-immune effectors are unusually cross-reactive. We could readily detect H2-M3wt-restricted responses to APC incubated with unrelated N-formylated peptides, and bacteria. HAA-like products represent an intriguing new set of bacterial antigens recognizable by immune CD8 cells.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Kurlander R,Nataraj Cdoi
10.1111/j.1600-065x.1997.tb00998.xsubject
Has Abstractpub_date
1997-08-01 00:00:00pages
123-8eissn
0105-2896issn
1600-065Xjournal_volume
158pub_type
杂志文章,评审abstract：:On the basis of cell surface markers, mature T cells are considered to have either a naïve or a memory phenotype. These cells exhibit distinct types of kinetic behaviour in vivo. While naïve-phenotype cells persist long term in a non-dividing state, memory-phenotype T cells include cycling cells and exhibit a more rap...
journal_title：Immunological reviews
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更新日期：2010-03-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2018-01-01 00:00:00
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更新日期：2019-11-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1600-065x.1989.tb00555.x
更新日期：1989-12-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2005-08-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2003-02-01 00:00:00
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更新日期：2002-07-01 00:00:00
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更新日期：2012-07-01 00:00:00
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journal_title：Immunological reviews
pub_type： 杂志文章,评审
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更新日期：1990-10-01 00:00:00
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journal_title：Immunological reviews
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更新日期：1987-04-01 00:00:00
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journal_title：Immunological reviews
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更新日期：2012-03-01 00:00:00
abstract：:The AIDS pandemic is a global emergency and a preventive vaccine is urgently needed. CD4 and CD8 T-cell responses appear important in controlling human immunodeficiency virus (HIV)-1 in humans and simian immunodeficiency virus (SIV) in macaques. The utility of vaccines that induce high levels of SIV- or HIV-specific T...
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更新日期：2001-10-01 00:00:00
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更新日期：2011-07-01 00:00:00
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更新日期：2006-02-01 00:00:00
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更新日期：2009-09-01 00:00:00
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更新日期：2011-01-01 00:00:00
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更新日期：2001-02-01 00:00:00
abstract：:The substantial importance of P-selectin glycoprotein ligand 1 (PSGL-1) in leukocyte trafficking has continued to emerge beyond its initial identification as a selectin ligand. PSGL-1 seemed to be a relatively simple molecule with an extracellular mucin domain extended as a flexible rod, teleologically consistent with...
journal_title：Immunological reviews
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更新日期：2009-07-01 00:00:00
abstract：:Studies over the last decade uncovered overlapping niches for hematopoietic stem cells (HSCs), multipotent progenitor cells, common lymphoid progenitors, and early B cell progenitors. HSC and lymphoid niches are predominantly composed by mesenchymal progenitor cells (MPCs) and by a small subset of endothelial cells. N...
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更新日期：2019-05-01 00:00:00
