Dendritic cell dysregulation during HIV-1 infection.

abstract：:In this review, we briefly cover the critical requirements for interleukin-7 (IL-7) in thymocyte development and peripheral T-cell homeostasis. Part of the IL-7 effect is antiapoptotic or 'trophic' and we have studied the intracellular pathways involved in lymphocyte survival and death regulated by this cytokine. We r...

journal_title：Immunological reviews

authors： Khaled AR,Durum SK

更新日期：2003-06-01 00:00:00

abstract：:Clarifying the signals that lead to dendritic cell (DC) development and identifying cellular intermediates on their way to DC differentiation are essential steps to understand the dynamic regulation of number, localization, and functionality of these cells. In the past decade, much knowledge on cytokines, transcriptio...

journal_title：Immunological reviews

authors： Schmid MA,Kingston D,Boddupalli S,Manz MG

更新日期：2010-03-01 00:00:00

abstract：:The cellular and molecular mechanisms underlying the formation of distinct central, effector, and exhausted CD8+ T-cell memory subsets were first described in the setting of acute and chronic viral diseases. The role of these T-cell memory subsets are now being illuminated as relevant to the tumor-bearing state. The g...

journal_title：Immunological reviews

authors： Klebanoff CA,Gattinoni L,Restifo NP

更新日期：2006-06-01 00:00:00

abstract：:In this review, we discuss the possibilities for combining the power of molecular analysis of the antigens expressed in a given individual tumor with the design of a tailored vaccine containing defined antigens. Step 1 is a differential gene expression analysis of tumor and corresponding normal tissue. Step 2 is the a...

journal_title：Immunological reviews

authors： Rammensee HG,Weinschenk T,Gouttefangeas C,Stevanović S

更新日期：2002-10-01 00:00:00

abstract：:The lung constantly interacts with the environment through thousands of liters of air that are inhaled daily. This continually transports toxic chemicals and particles or pathogenic microorganisms deep into the respiratory system, posing a challenge to physicochemical barriers and the local immune system. Thus, comple...

journal_title：Immunological reviews

authors： Hasenberg M,Stegemann-Koniszewski S,Gunzer M

更新日期：2013-01-01 00:00:00

abstract：:Polymorphonuclear neutrophils (PMNs) are innate immune system cells that play an essential role in eradicating invading pathogens. PMN migration to sites of infection/inflammation requires exiting the microcirculation and subsequent crossing of epithelial barriers in mucosa-lined organs such as the lungs and intestine...

journal_title：Immunological reviews

authors： Brazil JC,Parkos CA

更新日期：2016-09-01 00:00:00

abstract：:Natural killer cells employ a diverse arsenal of effector mechanisms to target intracellular pathogens. Differentiation of natural killer (NK) cell activation pathways occurs along a continuum from reliance on innate pro-inflammatory cytokines and stress-induced host ligands through to interaction with signals derived...

journal_title：Immunological reviews

authors： Goodier MR,Wolf AS,Riley EM

更新日期：2020-01-01 00:00:00

abstract：:Non-human primate (NHP) models, especially involving macaques, are considered important models of human immunity and have been essential in preclinical testing for vaccines and therapeutics. Despite this, much less characterization of macaque Fc receptors has occurred compared to humans or mice. Much of the characteri...

journal_title：Immunological reviews

authors： Chenoweth AM,Trist HM,Tan PS,Wines BD,Hogarth PM

更新日期：2015-11-01 00:00:00

abstract：:A byproduct of the largely stochastic generation of a diverse B-cell specificity repertoire is production of cells that recognize autoantigens. Indeed, recent studies indicate that more than half of the primary repertoire consists of autoreactive B cells that must be silenced to prevent autoimmunity. While this silenc...

journal_title：Immunological reviews

authors： Yarkoni Y,Getahun A,Cambier JC

更新日期：2010-09-01 00:00:00

abstract：:Inflammasome biology is one of the most exciting and rapidly growing areas in immunology. Over the past 10 years, inflammasomes have been recognized for their roles in the host defense against invading pathogens and in the development of cancer, auto-inflammatory, metabolic, and neurodegenerative diseases. Assembly of...

journal_title：Immunological reviews

authors： Man SM,Kanneganti TD

更新日期：2015-05-01 00:00:00

abstract：:Nuclear-factor κB (NF-κB) transcription factors are activated by a wide variety of stimuli in diverse cell types and control key aspects of immune function and development. Receptor-mediated activation of NF-κB appears to occur through two distinct signaling pathways termed as the canonical and non-canonical NF-κB pat...

journal_title：Immunological reviews

authors： Razani B,Reichardt AD,Cheng G

更新日期：2011-11-01 00:00:00

abstract：:More than 20 years ago, immunologists discovered that resistance and susceptibility to experimental infection with the intracellular protozoan Leishmania major was associated with the development of T-helper 1 (Th1)- and Th2-dominated immune responses, respectively. This infectious disease model was later used to iden...

journal_title：Immunological reviews

authors： Mougneau E,Bihl F,Glaichenhaus N

更新日期：2011-03-01 00:00:00

abstract：:One of the fundamental aspects of the innate immune system is its capacity to discriminate between self and non-self or altered self, and to quickly respond by eliciting effector mechanisms that act in concert to restore normalcy. This capacity is determined by a set of evolutionarily conserved pattern recognition rec...

journal_title：Immunological reviews

authors： Saleh M

更新日期：2011-09-01 00:00:00

abstract：:The screening of tumor-derived expression libraries for antigens detected by high-titer immunoglobulin G antibodies from the sera of patients with cancer by SEREX (serological identification of antigens by recombinant expression cloning) allows a systematic search for antigens of human cancers. SEREX has led to the id...

journal_title：Immunological reviews

authors： Preuss KD,Zwick C,Bormann C,Neumann F,Pfreundschuh M

更新日期：2002-10-01 00:00:00

abstract：:The human leukocyte receptor complex (LRC) contains at least 26 genes which belong to the immunoglobulin superfamily The genes include two clusters of immunoglobulin-like transcript (ILT)/leukocyte immunoglobulin-like receptor (LIR)/monocyte-macrophage inhibitory receptor (MIR) loci, a cluster of killer cell inhibitor...

journal_title：Immunological reviews

authors： Volz A,Wende H,Laun K,Ziegler A

更新日期：2001-06-01 00:00:00

abstract：:The recurrence in the V-gene repertoire of individual germline VH genes can now be extended from the restricted B-cell populations of the fetus, autoantibodies and B-cell malignancies to the expressed V-gene repertoire of normal adults. Why the human B cell preferentially utilizes these individual VH genes remains spe...

journal_title：Immunological reviews

authors： Stewart AK,Huang C,Long AA,Stollar BD,Schwartz RS

更新日期：1992-08-01 00:00:00

abstract：:Over the past 20 years, major progress has been made in our understanding of natural killer (NK) cells. It has become clear that NK cells are regulated by a number of receptors with opposite functions that finely tune potent effector functions such as cytolytic activity and release of cytokines that play a major role ...

journal_title：Immunological reviews

authors： Moretta A,Locatelli F,Moretta L

更新日期：2008-08-01 00:00:00

abstract：:The surface molecules that mediate activation of different subsets of T or NK cells have been reviewed. A suitable approach to the study of different lymphocyte activation pathways is provided by mAbs specific for these molecules. MAbs directed to the CD3 surface molecules mediate a polyclonal T-cell activation, where...

journal_title：Immunological reviews

authors： Moretta A,Ciccone E,Pantaleo G,Tambussi G,Bottino C,Melioli G,Mingari MC,Moretta L

更新日期：1989-10-01 00:00:00

abstract：:The characterization of the microenvironment of human tumors led to the description of tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T-cell zone adjacent to B-cell follicle including a germinal center. TLS represent sites of lymphoid neogenesis that develop in most solid cancers. Anal...

journal_title：Immunological reviews

authors： Dieu-Nosjean MC,Giraldo NA,Kaplon H,Germain C,Fridman WH,Sautès-Fridman C

更新日期：2016-05-01 00:00:00

abstract：SUMMARY:B7-H3 and B7-H4 belong to a new class of immune regulatory molecules, which primarily execute their functions in peripheral tissues to fine tune immune responses in target organs. In normal circumstances, while the mRNA for both molecules is broadly distributed, tight control at the post-transcriptional level i...

journal_title：Immunological reviews

authors： Yi KH,Chen L

更新日期：2009-05-01 00:00:00

abstract：:Once across the barrier of the epithelium, macrophages constitute the primary defense against microbial invasion. For most microbes, the acidic, hydrolytically competent environment of the phagolysosome is sufficient to kill them. Despite our understanding of the trafficking events that regulate phagosome maturation, ...

journal_title：Immunological reviews

authors： Rohde K,Yates RM,Purdy GE,Russell DG

更新日期：2007-10-01 00:00:00

abstract：:The individual role of pathogen-binding Toll-like receptors (TLRs) and antibody-binding Fc receptors (FcRs) during pathogenic infections has been studied extensively. However, combined activation of these different receptor classes has received little attention, even though they are triggered simultaneously when immun...

journal_title：Immunological reviews

authors： van Egmond M,Vidarsson G,Bakema JE

更新日期：2015-11-01 00:00:00

abstract：:GITR [glucocorticoid inducible tumor necrosis factor receptor (TNFR)-related protein] and 4-1BB are costimulatory TNFR family members that are expressed on regulatory and effector T cells as well as on other cells of the immune system. Here we discuss the role of GITR and 4-1BB on T cells during viral infections and i...

journal_title：Immunological reviews

authors： Snell LM,Lin GH,McPherson AJ,Moraes TJ,Watts TH

更新日期：2011-11-01 00:00:00

abstract：:Lymphocytes can interfere with the activity of other lymphocytes in a thousand and one ways. A particular subset of so-called regulatory CD4+ T cells is capable of controlling the activity of other lymphocytes in yet another way. Their function is primarily defined by the ability to protect the integrity of tissues an...

journal_title：Immunological reviews

authors： Annacker O,Pimenta-Araujo R,Burlen-Defranoux O,Bandeira A

更新日期：2001-08-01 00:00:00

abstract：:Viruses have often been associated with autoimmune diseases. One mechanism by which self-destruction can be triggered is molecular mimicry. Many examples of cross-reactive immune responses between pathogens and self-antigens have been described. This review presents two transgenic models of autoimmune disease induced ...

journal_title：Immunological reviews

authors： von Herrath MG,Evans CF,Horwitz MS,Oldstone MB

更新日期：1996-08-01 00:00:00

abstract：:The structure and amino acid diversity of the T-cell receptor (TCR), similar in nature to that of Fab portions of antibodies, would suggest that these proteins have a nearly infinite capacity to recognize antigen. Yet all currently defined native T cells expressing an α and β chain in their TCR can only sense antigen ...

journal_title：Immunological reviews

authors： Castro CD,Luoma AM,Adams EJ

更新日期：2015-09-01 00:00:00

abstract：:TCR repertoire studies in RA have yielded conflicting data. These studies were initiated on the premise that clonal expression of T cells at the site of inflammation could serve as a target for immune therapies designed on the basis of the option to inactivate or eliminate the presumed pathogenic T cells. These analys...

journal_title：Immunological reviews

authors： Breedveld FC,Struyk L,van Laar JM,Miltenburg AM,de Vries RR,van den Elsen PJ

更新日期：1995-04-01 00:00:00

abstract：:As biomedical research becomes increasingly data-intensive, it is increasingly essential to integrate genomic-scale datasets, so as to generate a more holistic picture of complex biological processes. The systems biology paradigm may differ in strategy from traditional reductionist scientific methods, but the goal rem...

journal_title：Immunological reviews

authors： Beiting DP,Roos DS

更新日期：2011-03-01 00:00:00

abstract：:In mice, the absence of terminal deoxynucleotidyl transferase (Tdt) expression during fetal and neonatal life provides a window in development where clones of lymphocytes are generated that provide protective immunity. Introducing premature Tdt activity interferes with the development of these clones and results in an...

journal_title：Immunological reviews

authors： Benedict CL,Gilfillan S,Thai TH,Kearney JF

更新日期：2000-06-01 00:00:00

abstract：:Immunity results from a complex interplay between the antigen-non-specific innate immune system and the antigen-specific adaptive immune system. The cells and molecules of the innate system employ non-clonal recognition receptors including lectins, Toll-like receptors, NOD-like receptors, and helicases. B and T lympho...

journal_title：Immunological reviews

authors： Ueno H,Schmitt N,Klechevsky E,Pedroza-Gonzalez A,Matsui T,Zurawski G,Oh S,Fay J,Pascual V,Banchereau J,Palucka K

更新日期：2010-03-01 00:00:00