Abstract：
:Immunity results from a complex interplay between the antigen-non-specific innate immune system and the antigen-specific adaptive immune system. The cells and molecules of the innate system employ non-clonal recognition receptors including lectins, Toll-like receptors, NOD-like receptors, and helicases. B and T lymphocytes of the adaptive immune system employ clonal receptors recognizing antigens or their derived peptides in a highly specific manner. An essential link between innate and adaptive immunity is provided by dendritic cells (DCs). DCs can induce such contrasting states as immunity and tolerance. The recent years have brought a wealth of information on the biology of DCs revealing the complexity of this cell system. Indeed, DC plasticity and subsets are prominent determinants of the type and quality of elicited immune responses. In this article, we summarize our recent studies aimed at a better understanding of the DC system to unravel the pathophysiology of human diseases and design novel human vaccines.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Ueno H,Schmitt N,Klechevsky E,Pedroza-Gonzalez A,Matsui T,Zurawski G,Oh S,Fay J,Pascual V,Banchereau J,Palucka Kdoi
10.1111/j.0105-2896.2009.00884.xsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
199-212issue
1eissn
0105-2896issn
1600-065Xpii
IMR884journal_volume
234pub_type
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